 | James Franco als Aron Ralston |
 | Amber Tamblyn als Megan McBride |
 | Kate Mara als Kristi Moore |
 | Clémence Poésy als Rana |
 | Kate Burton als Aron's Mom |
 | Lizzy Caplan als Sonja Ralston |
 | Sean Bott als Aron's Friend |
 | Koleman Stinger als Aron Age 5 |
 | Treat Williams als Aron's Dad |
| John Lawrence als Brian |
 | Bailee Michelle Johnson als Sonja Age 10 |
| Parker Hadley als Aron Age 15 |
 | Fenton Quinn als Blue John |
| Peter Joshua Hull als Boy on Sofa |
 | Pieter Jan Brugge als Eric Meijer |
| Rebecca C. Olson als Monique Meijer |
| Jeffrey Wood als Andy Meijer |
 | Norman Lehnert als Dan |
| Xmas Lutu als Helicopter Co-Pilot |
| Terry S. Mercer als Helicopter Pilot |
 | Darin Southam als Zach |
| Johnny Ahn als Basketball Fan (uncredited) |
| Robert Bear als Aron's Friend (uncredited) |
| Adam Colvin als Summer Party Man (uncredited) |
| Luke Drake als Aron's Friend (uncredited) |
| Christopher K. Hagadone als Basketball Fan (uncredited) |
 | Elizabeth Hales als Patron (uncredited) |
| Zachary Haycock als Reporter (uncredited) |
| Kelly Higgins als Fan (uncredited) |
 | Brad Johnson als Aron's Friend (uncredited) |
 | Lonzo Liggins als Reporter (uncredited) |
| Samantha Marsden als Media Person / Basketball Game Fan (uncredited) |
| Kelsie Mathews als Basketball Fan (uncredited) |
 | Kyle Paul als Best Man (uncredited) |
| Priscilla Poland als Bridesmaid (uncredited) |
 | Aron Ralston als Self (uncredited) |
| Jessica Ralston als Self (uncredited) |
| Amy Savannah als Basketball Fan (uncredited) |
 | Stacey Ann Turner als Aron's Friend (uncredited) |
| Danny Boyle | Director |
| A.R. Rahman | Original Music Composer |
| Simon Beaufoy | Screenplay |
| Danny Boyle | Screenplay |
| Bernard Bellew | Executive Producer |
| Lisa Maria Falcone | Executive Producer |
| François Ivernel | Executive Producer |
| John J. Kelly | Executive Producer |
| Cameron McCracken | Executive Producer |
| Tessa Ross | Executive Producer |
| Danny Boyle | Producer |
| Christian Colson | Producer |
| John Smithson | Producer |
| Jon Harris | Editor |
| Donna Isaacson | Casting |
| Suttirat Anne Larlarb | Production Design |
| Christopher R. DeMuri | Art Direction |
| Les Boothe | Set Decoration |
| Cynthia A. Neibaur | Set Decoration |
| Gina Homan | Makeup Department Head |
| Stephanie Scott | Makeup Department Head |
| Jacqueline Newell | Costume Supervisor |
| Brent Astrope | Construction Coordinator |
| Sam Demke | Sculptor |
| Michael T. Higgins | Leadman |
| Hollie Howton | Art Department Coordinator |
| Scott Ruley | Greensman |
| Nicolas Becker | Foley |
| Glenn Freemantle | Supervising Sound Editor |
| Glenn Freemantle | Sound Designer |
| James Shannon | Dolby Consultant |
| Alfonso Calvo | Sound Re-Recording Mixer |
| Richard Pryke | Sound Re-Recording Mixer |
| Ian Tapp | Sound Re-Recording Mixer |
| Niv Adiri | Sound Re-Recording Mixer |
| Tim Caplan | Visual Effects Producer |
| David Sanger | Visual Effects Producer |
| James Winnifrith | Visual Effects Editor |
| Adam Gascoyne | Visual Effects Supervisor |
| Patrick J. Statham | Stunt Coordinator |
| Thomas Neivelt | Gaffer |
| Babak Mansouri | Camera Operator |
| Chuck Zlotnick | Still Photographer |
| Michelle l Boucher | Set Costumer |
| John Warhurst | Music Editor |
| Britani Alexander | Transportation Coordinator |
| Linda DeVilliers | Studio Teachers |
| Kristin Ludwin | Script Supervisor |
| Tracey Merkle | Script Supervisor |
| Dennis Light | Location Manager |
| Lora Laing | Hairstylist |
| Jeanette Haley | Post Production Supervisor |
| Blair Foord | Special Effects Supervisor |
| Emma Potter | Assistant Costume Designer |
| Elisabeth Vastola | Assistant Costume Designer |
| Miles Levy | Thanks |
| Anthony Dod Mantle | Director of Photography |
| Enrique Chediak | Director of Photography |
| Justin Andrews | Gaffer |
| Steven C. Laneri | Sound Mixer |
| Douglas Cameron | Sound Mixer |
| Emilie O'Connor | Dialogue Editor |
| Sean Kenney | Contact Lens Technician |
| Jenna Kilgrow | Hair Department Head |
| Octaviano de Jesus Cesar Junior | Makeup Artist |
| Christianna Mower | Makeup Artist |
| Layne Robinson | Construction Foreman |
| Linden Snyder | Draughtsman |
| Scott Hinckley | Set Dresser |
| Gabriel Jessop | Set Dresser |
| Matthew Webb | Set Dresser |
| Brendan Houghton | Storyboard Artist |
| Janet Kusnick | Storyboard Artist |
| David B. Nowell | Aerial Director of Photography |
| Adam Smith | Best Boy Electric |
| David Stoddard | Best Boy Electric |
| Glade Quinn | Best Boy Grip |
| Jason Walser | Best Boy Grip |
| Michael B. Call | Camera Operator |
| Chris Cavanaugh | Digital Imaging Technician |
| Stefan Ciupek | Digital Imaging Technician |
| Michael Mansouri | Digital Imaging Technician |
| Judd Hillman | Electrician |
| Josh Lee | Electrician |
| John Raymer | Electrician |
| Charles Unice | Electrician |
| Gary Johnson | First Assistant Camera |
| Dominic Napolitano | First Assistant Camera |
| Zep Christensen | First Assistant Camera |
| Nino Neuboeck | First Assistant "A" Camera |
| Andrew Hicks | Grip |
| Tracy Keele | Grip |
| Craig Sullivan | Grip |
| Daniel Courtright | Key Grip |
| Alan E. Stoddard | Key Grip |
| Scott Goslin | Lighting Technician |
| Peter Weiland | Lighting Technician |
| Nathan Armstrong | Second Assistant Camera |
| Kurtis Burr | Second Assistant Camera |
| Simon Miya | Second Assistant Camera |
| Joel Remke | Second Assistant Camera |
| David Erickson | Second Assistant Camera |
| Peter Zuccarini | Underwater Camera |
| Jason Montgomery | Casting Associate |
| Katie Jensen | Extras Casting |
| Jong Yun | Extras Casting Assistant |
| Rie Attridge | Local Casting |
| Tori Silvera Bush | Location Casting |
| Matt Adams | Digital Intermediate |
| Richard Etchells | Digital Intermediate Editor |
| Matthew Bristowe | Digital Intermediate Producer |
| Todd Kleparski | Digital Intermediate Producer |
| James Cundill | Online Editor |
| Dominic Thomson | Online Editor |
| Ivor Middleton | Animation |
| Peter A. Chevako | Special Effects |
| Michael Roundy | Special Effects Technician |
| Ryan Roundy | Special Effects Technician |
| J. Scott Smiley | First Assistant Director |
| David Ticotin | First Assistant Director |
| Heather Toone | Second Assistant Director |
| Jeremy Westerman | Animal Wrangler |
| Cliff Fleming | Pilot |
| Craig Ayers | Production Coordinator |
| Jennifer Chapman | Production Secretary |
| Meg Halsey | Production Secretary |
| Matt Curtis | Title Designer |
| Craig Ayers | Production Supervisor |
| Duff Rich | Production Supervisor |
| Gary Archer | Prosthetics |
| William Aldridge | Special Effects Coordinator |
| Scott Arneman | Property Master |
| Jonas Sappington | On Set Dresser |
| Krystle Grandy | Production Assistant |
| Suttirat Anne Larlarb | Costume Designer |
| Aron Ralston | Book |
