 | Adam Sandler als Henry Roth |
 | Drew Barrymore als Lucy Whitmore |
 | Rob Schneider als Ula |
 | Sean Astin als Doug Whitmore |
 | Lusia Strus als Alexa |
 | Dan Aykroyd als Dr. Keats |
 | Amy Hill als Sue |
 | Allen Covert als Ten Second Tom |
 | Blake Clark als Marlin Whitmore |
 | Maya Rudolph als Stacy |
 | Pomaika'i Brown als Nick |
 | Joe Nakashima als Old Hawaiian Man |
 | Peter Dante als Security Guard |
 | Dom Magwili als Security Guard |
 | Jonathan Loughran als Jennifer |
 | J.D. Donaruma als Pablo |
 | Wayne Federman als Patient |
 | Kent Avenido als Cook's Helper |
 | Sharon Omi als Café Regular |
 | Glen Chin als Café Regular |
 | Aukuso Gus Puluti, Sr. als Café Regular |
| Adam Juegos als Ula's Kid |
| James Lee als Ula's Kid |
 | Kylie Moore als Ula's Kid |
| Keali'i Olmos als Ula's Kid |
| Tache Uesugi als Ula's Kid |
 | Lynn Collins als Linda |
 | Esmond Chung als Sheriff |
 | Kristin Bauer als Female Firefighter |
| Ishtar Uhvana als Salon Worker |
 | Brenda Vivian als Salon Patron |
 | Chantell D. Christopher als Salon Patron |
 | Nika King als Salon Patron |
 | Nectar Rose als Blonde in Office |
 | Jackie Sandler als Dentist |
| Linda Segal als Patient in Dentist Office |
| Lin Yan als Coroner |
| Nicola Hersh als Woman in Car |
 | Virginia Reece als Redhead |
 | Melissa Lawner als Tan Friend |
 | Katheryn Winnick als Young Woman |
| David Suapaia als Stacy's Husband |
 | Peter Chen als Caddy |
| Marguerite Cazin als Henry & Lucy's Daughter |
 | Kevin James als Factory Worker |
| Michael K. Osborn als Sea Lion Trainer |
| Denise Bee als Ula's Wife |
| Albert Chi als Waiter |
 | Brian L. Keaulana als Jet Skiier |
 | Americus Abesamis als Cafe Regular (uncredited) |
| Erika Ambrose als Girl in factory (uncredited) |
 | Eric Bruno Borgman als Minor Role (uncredited) |
 | Jessica Bowman als Tamy (uncredited) |
 | Alice Dinnean als Undetermined Minor Role (uncredited) |
 | Paul Edney als Seaplane Pilot (uncredited) |
| Darin Fujimori als Fisherman (uncredited) |
| Zoe Galvez als Minor Role (uncredited) |
| Jordan Kirkwood als Bar Drinker (uncredited) |
 | Michelle Lee als Woman (uncredited) |
 | Scott Menville als Man at the restaurant (uncredited) |
 | Deanna Mustard als Undetermined Minor Role (uncredited) |
| Anthony Patricio als Hawaiian Trucker (uncredited) |
 | Mark Pinkosh als Repairman (uncredited) |
 | Missi Pyle als Noreen (uncredited) |
| Darlena Roberts als Amnesia Patient (uncredited) |
 | John Patrick Shulak als Tourist (uncredited) |
 | Meilinda Cecilia Soerjoko als Airport Passanger (uncredited) |
 | Anne Stedman als Ex-Girlfriend (uncredited) |
| George Wing | Screenplay |
| Peter Segal | Director |
| Jack N. Green | Director of Photography |
| Jeff Gourson | Editor |
| Kevin Grady | Associate Producer |
| Michael Ewing | Executive Producer |
| Jack Giarraputo | Producer |
| Steve Golin | Producer |
| Daniel Lupi | Executive Producer |
| Jay Roach | Executive Producer |
| Scott Bankston | Co-Producer |
| Larry Kennar | Co-Producer |
| Nancy Juvonen | Producer |
| Rose Librizzi | Makeup Department Head |
| Lona Vigi | Hairstylist |
| Pauletta O. Lewis | Key Hair Stylist |
| Ellen Lutter | Costume Design |
| Bill Coe | First Assistant Camera |
| Derek Vanderhorst | Supervising Sound Effects Editor |
| Cameron Steenhagen | Sound Effects Editor |
| Nancy Karlin | Script Supervisor |
| Domenic Silvestri | Art Direction |
| Stephen S. Campanelli | Camera Operator |
| Michael Dilbeck | Music Supervisor |
| Robert Greenfield | Set Decoration |
| Jeannie H. Kelly | Assistant Costume Designer |
| Robin Fredriksz | Makeup Artist |
| Will Weiske | Production Supervisor |
| Susan Ehrhart | Production Coordinator |
| Stuart Grusin | Music Editor |
| David Kelson | Production Sound Mixer |
| Ann Pala | Makeup Artist |
| Victoria Alonso | Visual Effects Producer |
| Teddy Castellucci | Original Music Composer |
| Robert Q. Mathews | Costume Supervisor |
| Webster Whinery | Stunt Coordinator |
| Elmo Weber | Supervising Sound Editor |
| Orada Jusatayanond | Sound Effects Editor |
| Sheena Duggal | Visual Effects Supervisor |
| Darren Michaels | Still Photographer |
| Nancy Tong | Hair Department Head |
| Elizabeth Boykewich | Casting Associate |
| Donald B. Woodruff | Assistant Art Director |
| J.J. George | Music Editor |
| Alan Au | Production Design |
| Roger Mussenden | Casting |
| David Carberry | Painter |
| Gregory S. Hooper | Set Designer |
| Bill 'Kauhane' Hoyt | Standby Painter |
| Spooky Stevens | Unit Publicist |
| Bob Skemp | Greensman |
| Laurel Frushour | Set Costumer |
| Geno Hart | Transportation Coordinator |
| Eddie Soria | Visual Effects Coordinator |
| James D. Bissell | Second Unit |
| David Gasperik | Additional Camera |
| John Charles | Software Engineer |
| Justin Duval | Electrician |
| Rodney Brown Alamo | Location Manager |
| Dave Moorer | Set Medic |
| Pete Anthony | Orchestrator |
| Dru Homer | Art Department Coordinator |
| Karen Higgins | Construction Coordinator |
| Kirk Huston | Transportation Captain |
| Alfred Ainsworth | Video Assist Operator |
| T. Daniel Scaringi | Rigging Grip |
| Mark Weissenfluh | Leadman |
| Sandy Reed | Craft Service |
| Bruce Comtois | Driver |
| Reid Paul | Digital Effects Supervisor |
| Laura Weiss | Assistant Director |
| Scott Trimble | Location Scout |
| Rick Crum | Grip |
| Mike Macias | Lighting Technician |
| Megan Mathews | Production Accountant |
| Skip Kimball | Telecine Colorist |
| Steve Rhee | Visual Effects Editor |
| Clare Hallworth | Assistant Costume Designer |
| Richard Robinson | Propmaker |
| Robert Jackson | Boom Operator |
| Nicole Nakamoto | Art Department Assistant |
| Bruce Richter | Carpenter |
| Dan Muscarella | Color Timer |
| Daniel Lupi | Unit Production Manager |
| Crystal Michelle | Stunts |
| Marc Glassman | Foley Editor |
| Russell Farmarco | ADR Editor |
| Thomas Cobb | Title Designer |
| Charles Saldaña | Key Grip |
| Drake Jenevein | Assistant Sound Editor |
| Shayna Ritenour | Camera Loader |
| Kendra Carter | Casting Assistant |
| Hans Bjerno | Aerial Director of Photography |
| Mo Henry | Negative Cutter |
| Joseph J. Kontra | Second Assistant Director |
| Demelza Cronin | Assistant Production Coordinator |
| Mike Deasy | Musician |
| Adam Druxman | First Assistant Director |
| Daniel Brock | Utility Sound |
| John Puglisi | Conceptual Illustrator |
| Oscar Delgadillo | Set Dresser |
| Carme Tenuta | Key Makeup Artist |
| David Bach | ADR Supervisor |
| James D. Wickman | Dolly Grip |
| Robert Jackson | Dialogue Editor |
| Sean Landeros | Sound Recordist |
| Timothy S. Wiles | Property Master |
| Timothy Grant Engle | Second Second Assistant Director |
| Claudia Bestor | Assistant Location Manager |
| Lea Lambert | Rotoscoping Artist |
| Chris Samp | Set Painter |
| Todd Mesher | Visual Effects Compositor |
| Jim Bissell | Second Unit Director |
| P.K. MacCarthy | Storyboard Artist |
| Vincent Guisetti | Foley Artist |
| Roger Kelton | Special Effects Technician |
| Howard Carle | ADR Mixer |
| Kyle Rochlin | Foley Mixer |
| Anthony Franco | Costumer |
| Ricky Johnson | Construction Grip |
| Steven Butensky | Assistant Accountant |
| T. Daniel Scaringi | Key Rigging Grip |
| Scott Berrie | Production Assistant |
| Mele K.T. Locey | Extras Casting Assistant |
| Michael Roccuzzo | Payroll Accountant |
| Kenny Gallagher | Second Assistant Accountant |
| Howard London | ADR Recordist |
| Brycen Counts | Stunt Double |
| Matthew D. Smith | Additional Second Assistant Director |
| Greg Curry | Colorist |
| Christian Boudman | Digital Compositor |
| Georgina Marquis | Travel Coordinator |
| Martin Charles | Graphic Designer |
| Adam Pinkstaff | Stunt Driver |
| Michael K. O'Melia | Assistant Chief Lighting Technician |
| Brad Kenny | Extras Casting |
| Matthew Berner | Assistant Camera |
| Paul McGhee | Digital Color Timer |
| Kerri Smeltzer | Production Secretary |
| Alex Hillkurtz | Storyboard Artist |
| Michael Adams | Stunts |
| Katie Wright Pere | Stunts |
| Paul Eliopoulos | Stunts |
| Michael T. Brady | Stunts |
| Gary Guercio | Stunts |
