 | Tom Hanks als Fred Rogers |
 | Matthew Rhys als Lloyd Vogel |
 | Chris Cooper als Jerry Vogel |
 | Susan Kelechi Watson als Andrea Vogel |
 | Maryann Plunkett als Joanne Rogers |
 | Enrico Colantoni als Bill Isler |
 | Wendy Makkena als Dorothy Vogel |
 | Tammy Blanchard als Lorraine Vogel |
 | Noah Harpster als Todd |
 | Carmen Cusack als Margy Whitmer |
 | Kelley Davis als First AD |
 | Christine Lahti als Ellen |
 | Maddie Corman als Betty Aberlin |
| Daniel Krell als Mr. McFeely |
| Jon L Peacock als Sound Technician |
 | Gretchen Koerner als Doctor |
| Gavin Borders als Young Boy |
| Mark August als Young Boy's Dad |
| Tressa Glover als Young Boy's Mom |
 | Jessica Hecht als Lila Vogel |
 | Di Zhu als Waitress |
| Diane Monroe als Uptown String Quartet |
| Maxine Roach als Uptown String Quartet |
| Lesa Terry als Uptown String Quartet |
| Tahirah Whittington als Uptown String Quartet |
| Nigel Swinson als Subway Singer |
| Kayla Fan als Subway Singer |
| Alexander Ment als Subway Singer |
| Madeline Ment als Subway Singer |
| Olivia Irene Ruiz als Subway Singer |
| Kiesse Yengo-Passy als Subway Singer |
| Marcel Kottmann als Subway Singer |
| John Castagliola als Subway Singer |
| Preston Lopez als Subway Singer |
| Reginald Bannerman als Subway Singer |
| Spencer Lott als Puppeteer |
 | Haley Jenkins als Puppeteer |
| Marc Petrosino als Puppeteer |
| Kathleen Kim als Puppeteer |
| Kathleen Antonia als Phone Operator (uncredited) |
| Saira Awan als Nurse Miscellaneous Crew (uncredited) |
 | Krizia Bajos als Argentinian Girl (uncredited) |
| Tom Bonello als WQED Grip and Electric (uncredited) |
| Gregory Bromfield als Awards Banquet Waiter (uncredited) |
 | Francesca Calo als Train Passenger (uncredited) |
| Kitty Crystal als Subway Punk (uncredited) |
| Amy Lyn Elliott als WQED Makeup Artist (uncredited) |
 | Joe Fishel als Journalist (uncredited) |
| Nate Heller als Wedding Band Lead Guitarist (uncredited) |
| Bill Isler als Restaurant Patron (uncredited) |
 | Kevin L. Johnson als Darin Scharf (uncredited) |
| Rosie Koster als Esquire Employee (uncredited) |
 | Michael Masini als Richie (uncredited) |
| Kirsten McCain als Gala Attendee (uncredited) |
 | Patrick McDade als Rick (uncredited) |
 | David Newell als Restaurant Patron (uncredited) |
| Trevor Stevie Ray Ontiveros als New Yorker (uncredited) |
| Keith Otto als Gala Attendee (uncredited) |
 | Khary Payton als Arthur Mendez - Telegraph Clerk (uncredited) |
 | Alex Pérez als Parent (uncredited) |
| Katrina E. Perkins als Mr. Rogers Superfan (uncredited) |
 | Jivan Xander Ramesh als Mr. Rogers' Fan (uncredited) |
 | Scott Rapp als Bartender (uncredited) |
 | Fred Rogers als Self (archive footage) (uncredited) |
 | Joanne Rogers als Restaurant Patron (uncredited) |
| Edlyn Sabrina als Gala Guest (uncredited) |
| Erika Shrout als Mother (uncredited) |
| Laura Faye Smith als Julia Henderson - Fred's Secretary (uncredited) |
 | Rebecca Watson als Diana (uncredited) |
| Stephen West-Rogers als Peter (uncredited) |
| Ted Williams als WQED Electrician (uncredited) |
| Avy Kaufman | Casting |
| Kelley Cribben | Post Production Supervisor |
| Peter Saraf | Producer |
| Marc Turtletaub | Producer |
| David Boulton | ADR Recordist |
| Anne McCabe | Editor |
| Arjun Bhasin | Costume Design |
| Tony Martinez | ADR Editor |
| Tony Martinez | Supervising Dialogue Editor |
| Gary Kosko | Art Direction |
| Jim Emswiller | In Memory Of |
| Brian 'Buzz' Buzzelli | Dolly Grip |
| Adele Plauche | Set Designer |
| Jay Peck | Foley Artist |
| Mark DeSimone | ADR Recordist |
| Rene Mousseux | Stunts |
| Howard Paar | Music Supervisor |
| Jody Lee Lipes | Director of Photography |
| Jade Healy | Production Design |
| Doug Coleman | Stunt Coordinator |
| Marielle Heller | Director |
| Noah Harpster | Screenplay |
| Noah Harpster | Executive Producer |
| Bergen Swanson | Executive Producer |
| Bergen Swanson | Unit Production Manager |
| Tom Junod | Original Concept |
| Youree Henley | Producer |
| Christopher Patrick | Makeup Artist |
| Merissa Lombardo | Set Decoration |
| Micah Fitzerman-Blue | Screenplay |
| Micah Fitzerman-Blue | Executive Producer |
| Ross Dunkerley | Chief Lighting Technician |
| Gregory A. Weimerskirch | Art Direction |
| Sam Ellison | Camera Operator |
| Ma Kalaadevi Ananda | Makeup Department Head |
| Darcie Buterbaugh | Costume Supervisor |
| Damian Volpe | Sound Designer |
| Damian Volpe | Supervising Sound Editor |
| Damian Volpe | Sound Re-Recording Mixer |
| Sean Garnhart | Sound Effects Editor |
| Brian Machleit | Stunts |
| Donald A. Kraus | Transportation Captain |
| Glenfield Payne | Sound Effects Editor |
| Lacey Terrell | Still Photographer |
| John M. Davis | Music Editor |
| Donita Miller | Key Hair Stylist |
| Janice F. Sperling | Production Coordinator |
| Darylin Nagy | Makeup Artist |
| Tony Ward | Hair Department Head |
| Rebecca Breckel | Script Supervisor |
| Leah Holzer | Producer |
| Nate Heller | Original Music Composer |
| Aurelia Winborn | First Assistant Camera |
| Michael Miller | ADR Recordist |
| Corey Sweazen | Assistant Art Director |
| Candace Orlandi | Hairstylist |
| Jason Renner | Hairstylist |
| Richard E. Chapla Jr. | Production Manager |
| Buzzy Burwell | Assistant Chief Lighting Technician |
| Tim Davies | Orchestrator |
| Tim Davies | Conductor |
| Buster Pile | Construction Coordinator |
| Philip Schneider | Property Master |
| Michael G. Richer | Construction Foreman |
| Raymond M. Tasillo | Special Effects Coordinator |
| Tomas Deckaj | First Assistant Director |
| Bill Sweeney | ADR Editor |
| Bill Sweeney | Foley Supervisor |
| Josh Child | Compositor |
| Tonya Smay | Digital Compositor |
| Frank Conforti | Transportation Co-Captain |
| Harrison Nesbit | Casting Associate |
| Amy Christensen | Digital Compositor |
| Shannen Walsh | Visual Effects Coordinator |
| Kim Fouche-Tipton | Transportation Coordinator |
| Teresa Donatelli | Art Department Coordinator |
| Brian Powers | Key Rigging Grip |
| Alta Marie Bialon | Hairstylist |
| Ilana McAllistor | Production Accountant |
| Jillian Rose Keenist | Costumer |
| Alyssa Batchelor | Second Second Assistant Director |
| Wyatt Bartlett | Costumer |
| Bobby Johanson | ADR Recordist |
| Bart Flaherty | Key Grip |
| Steven Weigle | Visual Effects Producer |
| Howard Chen | Executive Producer |
| Edward Cheng | Executive Producer |
| Filipe Messeder | Assistant Sound Editor |
| David Satin | Digital Imaging Technician |
| Brad Towell | Graphic Designer |
| Havilah Brewster | Associate Producer |
| Jim Dunlap | First Assistant Accountant |
| Grant Anderson | Visual Effects |
| John Sundquist | Stunts |
| Eve Negley | Makeup Artist |
| Emmanuelle Martin | Costume Coordinator |
| David Entin | Visual Effects Coordinator |
| Susan Ransom-Coyle | Second Assistant Director |
| Adam Dicterow | First Assistant Editor |
| James Hammer | Assistant Costume Designer |
| Aaron Streiner | Leadman |
| Cyndilee Rice | Key Makeup Artist |
| Tori Musial | Key Costumer |
| Chelsea Lynn Peterson | Extras Casting |
| Ginny Minuto | Craft Service |
| Gina La Monica | Costumer |
| Allan Barch | Assistant Chief Lighting Technician |
| Michael Zinobile | Best Boy Grip |
| Jason Millet | Storyboard Artist |
| David Billy Cole | Assistant Production Coordinator |
| Wenxin She | Co-Producer |
| Liz Hedges | Second Assistant Camera |
| Anthony Hechanova | Digital Imaging Technician |
| Gabe Marchetti | Camera Loader |
| Teeara Donner | Costumer |
| Emily McElroy | Costumer |
| Kent Jackson | Location Manager |
| Phil Pierre | Assistant Location Manager |
| Brandon Marlan | Assistant Location Manager |
| Greg Felmley | Assistant Location Manager |
| Alexandra Somand | Payroll Accountant |
| Jimmy Ray Sorrells | Assistant Accountant |
| Sarah Jane Grande | Assistant Accountant |
| Mamie Stein | Set Dresser |
| Alex Ghaffari | Casting Assistant |
