 | Steve Zahn als Cliff |
 | Milla Jovovich als Cydney |
 | Timothy Olyphant als Nick |
 | Kiele Sanchez als Gina |
 | Chris Hemsworth als Kale |
 | Marley Shelton als Cleo |
 | Holt McCallany als Police Lieutenant |
 | Anthony Ruivivar als Chronic |
 | Dale Dickey als Earth Momma |
 | Wendy Braun als Debbie Mason / Clerk |
 | Peter Navy Tuiasosopo als Supply Guy |
 | Jim Cruz als Helicopter Pilot |
| Isaac Santiago als Police shooter |
 | Matt Birman als Trekker |
| David Twohy | Director |
| Robert Bernacchi | Executive Producer |
| Bill Block | Executive Producer |
| Robbie Brenner | Producer |
| Camille Brown | Producer |
| Mark Canton | Producer |
| Scott Fischer | Executive Producer |
| Kimberly Fox | Executive Producer |
| Ken Halsband | Producer |
| Ryan Kavanaugh | Producer |
| Tucker Tooley | Producer |
| Tracy Adams | Editor |
| Anne McCarthy | Casting |
| Jay Scully | Casting |
| Joseph C. Nemec III | Production Design |
| Laura Goldsmith | Costume Design |
| Matthew W. Mungle | Makeup Effects |
| Christopher Kulikowski | Post Production Supervisor |
| Ines Mongil-Echandi | Production Supervisor |
| Brian M. O'Neill | Production Supervisor |
| Charlie Bonilla | Special Effects |
| Matt Birman | Stunt Coordinator |
| David Twohy | Screenplay |
| Mark Plummer | Director of Photography |
| Zina Torres | Art Direction |
| Lisa Alkofer | Set Decoration |
| Marta Ezal Colón | Assistant Hairstylist |
| Regina de Lemos | Assistant Makeup Artist |
| Blanca Nieves | Assistant Makeup Artist |
| Christine Aquino | Assistant Makeup Artist |
| Elenia Peña | Assistant Makeup Artist |
| Jacqueline Jiménez | Hair Department Head |
| Ángel Omar Cruz | Hairstylist |
| Annette Rodriguez | Hairstylist |
| Christina Smith | Makeup Artist |
| Marielena Ramirez | Makeup Department Head |
| Boris Elkis | Music |
| Carlos Zayas | Additional Second Assistant Camera |
| Michael Watson | Assistant Camera |
| Stephen Clancy | Camera Operator |
| Mark Plummer | Camera Operator |
| Frank Norris | Camera Trainee |
| Steve Koster | Director of Photography |
| Danny Falkengren | Dolly Grip |
| Angel Pastrana | Dolly Grip |
| Gustavo Accetta | Electrician |
| Alwayne Fletcher | Electrician |
| Ralston Williams | Electrician |
| Robert Smathers | First Assistant Camera |
| Tim Arasheben | First Assistant Camera |
| Earl Brown | Gaffer |
| Javier Cruzado | Grip |
| Cleveland McKenzie | Grip |
| Manuel Manny Rivera | Grip |
| Michael Milella | Key Grip |
| Raúl J. Marín | Key Rigging Grip |
| Anthony Zibelli | Libra Head Technician |
| Manuel "Tyson" Cintrón | Rigging Gaffer |
| Scott Beckley | Second Assistant Camera |
| Chris Browne | Second Assistant Camera |
| Javier Pesquera | Still Photographer |
| Peter Zuccarini | Underwater Director of Photography |
| Sorely Muentes | Art Department Coordinator |
| Oscar A. Colom Cruz | Assistant Property Master |
| Amilcar Rivera | Assistant Property Master |
| Derek Marengo | Construction Coordinator |
| Juan Guallini Indij | Head Greensman |
| Matthew Cavaliero | Property Master |
| Carlos 'Carly' Antunez | Set Dresser |
| Félix Caraballo | Set Dresser |
| Jason George | ADR Editor |
| Ron Bedrosian | ADR Mixer |
| Michael Miller | ADR Mixer |
| Greg Steele | ADR Mixer |
| Jay Petach | ADR Recordist |
| Greg Zimmerman | ADR Recordist |
| John Matter | Assistant Sound Editor |
| Kevin McCullough | Assistant Sound Editor |
| Greg Gardner | Boom Operator |
| William Munroe | Boom Operator |
| Edmund J. Lachmann | Dialogue Editor |
| Jed M. Dodge | Dialogue Editor |
| Jason George | Dialogue Editor |
| Guy Francoeur | Foley Artist |
| Benoît Leduc | Foley Recordist |
| Jo Caron | Foley Recordist |
| David Baldwin | Sound Effects Editor |
| David Barbee | Sound Effects Editor |
| Edmond J. Coblentz Jr. | Sound Effects Editor |
| Gary Macheel | Sound Effects Editor |
| Steven D. Grothe | Sound Mixer |
| Josh Eckberg | Sound Recordist |
| Marc Fishman | Sound Re-Recording Mixer |
| Tony Lamberti | Sound Re-Recording Mixer |
| Scott Martin Gershin | Sound Supervisor |
| George Haddad | Supervising Sound Editor |
| Lea Guivas-Murphy | Costumer |
| Natalia Collazo | Set Costumer |
| Katalina Iturralde | Set Costumer |
| Leslie Herman | Wardrobe Supervisor |
| Zoraida Sanjurjo López | Casting |
| Rhiannon Wescott | Casting Assistant |
| Kellie Roy | Casting Associate |
| Blake Harjes | Assistant Editor |
| Chris DeLaGuardia | Color Timer |
| Michael Underwood | Digital Colorist |
| Zahida Bacchus | Digital Intermediate Producer |
| Berenice Manjarrez Vericat | Assistant Production Coordinator |
| Jim Cruz | Pilot |
| Paul Morris | Pilot |
| Andrew Demarest | Key Production Assistant |
| Felipe Garcia | Key Production Assistant |
| Antonio Sifre | Legal Services |
| Ricardo L Betancourt | Production Assistant |
| Jana Camacho | Production Assistant |
| Fabiola Fortuno | Production Assistant |
| Kemel Jamís | Production Assistant |
| Anysha Lugo Sánchez | Production Assistant |
| Giancarlo Rebella | Production Assistant |
| Ben Adams | Production Assistant |
| Dean Sutherland | Production Assistant |
| Warren Dudley | Production Assistant |
| Christine Marino | Production Coordinator |
| Michyl-Shannon Quilty | Production Coordinator |
| Maxine Baillie | Production Coordinator |
| Jan Rudolph | Script Supervisor |
| José R. Varona | Set Medic |
| Carmen Marie Colón Mejía | Set Production Assistant |
| Kevin Davila | Stand In |
| Gladira Robles | Stand In |
| Diane Slattery | Unit Publicist |
| Luis A. Jurado | Transportation Coordinator |
| Alrick Burke | Transportation Coordinator |
| Luis R. Estrella-Rivera | Transportation Captain |
| Tracy Adams | Additional Music |
| Adam Klemens | Conductor |
| Ashley Revell | Music Editor |
| David Levy | Music Producer |
| Gina Amador | Music Supervisor |
| Doug Beep | Musician |
| Bob Robles | Musician |
| Dominik Hauser | Orchestrator |
| Michael J. Parker | 3D Artist |
| Kenneth Armstrong | Compositor |
| Ozzie Carmona | Compositor |
| Brad Gayo | Compositor |
| Craig Hilditch | Compositor |
| Elizabeth Marriner | Compositor |
| John Cornejo | Digital Compositor |
| Harimander Singh Khalsa | Digital Compositor |
| Mark Fenlason | Special Effects Coordinator |
| David B. Moulder | Visual Effects Producer |
| Joshua D. Comen | Visual Effects Producer |
| Jonah Loop | Visual Effects Supervisor |
| Tim Carras | Visual Effects Supervisor |
| Charlie Bonilla | Pyrotechnician |
| Willie Berrios | Special Effects Assistant |
| Robert Caban | Special Effects Assistant |
| Arturo J. Melero Gigante | Special Effects Assistant |
| Louis Martinez | Special Effects Assistant |
| Bryan Gonzales Rosano | Special Effects Assistant |
| Rafael Pérez | Special Effects Coordinator |
| Arturo Melero | Special Effects Technician |
| Brian Murray | Storyboard Artist |
