 | Elizabeth Daily als Tommy Pickles (voice) |
 | Christine Cavanaugh als Chuckie Finster (voice) |
 | Kath Soucie als Phil DeVille / Lil DeVille / Betty DeVille (voice) |
 | Cree Summer als Susie Carmichael / Edwin Carmichael (voice) |
 | Dionne Quan als Kimi Finster (voice) |
 | Ron Glass als Randy Carmichael (voice) |
 | Irma P. Hall als Aunt T. (voice) |
 | Crystal Scales als Buster Carmichael (voice) |
 | Hattie Winston als Lucy Carmichael / Lucy's Mom (voice) |
 | Kimberly Brooks als Young Lucy (voice) |
 | Bill Cobbs als Uncle Charles (voice) |
 | Erv Immeman als Radio Announcer (voice) |
 | Kevin Michael Richardson als Martin Luther King Jr. (voice) |
| Cynthia Kaye Hunt als Choir Soloist (voice) |
 | Joe Alaskey als Grandpa Lou Pickles (voice) |
 | Sam Saletta als Additional Voices (voice) |
| Bettina Bush als Alisa Carmichael (voice) |
| Anthony Bell | Director |
| Jill Gorey | Writer |
| Barbara Herndon | Writer |
| Lisa D. Hall | Writer |
| Arlene Klasky | Characters |
| Gábor Csupó | Characters |
| Paul Germain | Characters |
| Mark Mothersbaugh | Music |
| Robert Mothersbaugh | Music |
| Mark R. Crookston | Editor |
| Barbara Wright | Casting |
| Eryk Casemiro | Co-Executive Producer |
| Gábor Csupó | Executive Producer |
| Cella Nichols Duffy | Supervising Producer |
| Jim Duffy | Supervising Producer |
| Paul C. Fabela | Line Producer |
| Lorraine Gallacher | Co-Producer |
| Jill Gorey | Producer |
| Pernelle Hayes | Producer |
| Barbara Herndon | Producer |
| Arlene Klasky | Executive Producer |
| Anne Michaud | Line Producer |
| Susan Ward | Producer |
| Igor Kovalyov | Character Designer |