 | Storm Reid als Meg Murry |
 | Oprah Winfrey als Mrs. Which |
 | Reese Witherspoon als Mrs. Whatsit |
 | Mindy Kaling als Mrs. Who |
 | Levi Miller als Calvin O'Keefe |
 | Deric McCabe als Charles Wallace Murry |
 | Chris Pine als Dr. Alex Murry |
 | Gugu Mbatha-Raw als Dr. Kate Murry |
 | Zach Galifianakis als The Happy Medium |
 | Rowan Blanchard als Veronica Kiley |
 | Michael Peña als Red |
 | André Holland als Principal Jenkins |
 | Bellamy Young als Camazotz Woman |
 | David Oyelowo als The It (voice) |
 | Conrad Roberts als Elegant Man |
 | Lyric Wilson als Young Meg |
 | Yvette Cason als Mrs. Teacher |
 | Will McCormack als Mr. Teacher |
 | Daniel MacPherson als Calvin's Father |
 | Akemi Look als Air Force Officer |
 | Tim Kang als School Superintendent |
| Michele Norris als Radio News Broadcaster (voice) |
| Claire Montwill als Student |
| Catelynn Brown als Meg Double |
| Ariyah Brown als Meg Double |
| Losa Fifita als Meg Double |
| Joyce Larkin als Mrs. Who Double |
| Teonee Motley als Mrs. Which Double |
 | Jessica Rockwell als Mrs. Whatsit Double |
 | Oz Kalvan als Charles Wallace Double |
 | Isaac Ordonez als Charles Wallace Double |
| Kai Miller als Charles Wallace Double |
| Leighton Leevard als Charles Wallace Double |
| Guillaume Seeleuthner als Charles Wallace Double |
 | Jacob Eddington als Charles Wallace Double |
| Easton Tath als Baby Charles Wallace |
| Giselle Paredes als Baby Charles Wallace |
 | Punnavith Koy |
| Ava DuVernay | Director |
| Catherine Hand | Producer |
| Jim Whitaker | Producer |
| Ramin Djawadi | Original Music Composer |
| Spencer Averick | Editor |
| Madeleine L'Engle | Novel |
| Jennifer Lee | Screenplay |
| Jeff Stockwell | Screenplay |
| Ben O'Brien | Digital Compositor |
| Peter Ramsey | Storyboard Artist |
| Stacy Horn | Costume Supervisor |
| Brian Adler | Visual Effects |
| Adam Borba | Executive Producer |
| Douglas C. Merrifield | Executive Producer |
| Naomi Shohan | Production Design |
| Annie Dodman | Production Manager |
| Vinay Gautam | Production Manager |
| Pip Gillings | Production Manager |
| Carl Hampe | Production Supervisor |
| Geno Hart | Production Assistant |
| Ashish Kukian | Production Manager |
| Todd London | Post Production Assistant |
| Robert Mazaraki | Production Supervisor |
| Douglas C. Merrifield | Unit Production Manager |
| Sainath Shinde | Production Manager |
| Heidi Vogel | Post Production Supervisor |
| Lisa Chu | Additional Second Assistant Director |
| Deborah Chung | Additional Second Assistant Director |
| Betty Fotofili | Second Unit Director |
| LaTrisa Jackson | Second Assistant Director |
| Steve Love | First Assistant Director |
| David Marnell | Second Second Assistant Director |
| Dixon McPhillips | Additional Second Assistant Director |
| Rhys Summerhayes | Second Assistant Director |
| James Yang | Production Assistant |
| Lisa Zugschwerdt | Second Second Assistant Director |
| Christopher Manning | Stand In |
| Michael J. Moore | First Assistant Director |
| Dean Wolcott | Set Designer |
| Atsushi Nishijima | Still Photographer |
| Brittany Petros | Location Manager |
| Tobias A. Schliessler | Director of Photography |
| Ian Van der Werff | Key Set Production Assistant |
| Melissa Yonkey | Hairstylist |
| J.J. Abrams | Thanks |
| Katelyn Yoder | Assistant Production Coordinator |
| Cameron Wood | Location Scout |
| Michelle Chan Wong | Assistant Production Coordinator |
| Spencer R. Williams | Set Production Assistant |
| Marcus Wiley | Production Assistant |
| Amber Wegner | Stand In |
| Erin Waters | Set Production Assistant |
| Victoria Vanderlinden | First Assistant Accountant |
| Ian Van der Werff | Key Production Assistant |
| Warren Upson | Production Assistant |
| Lora Umphress | Payroll Accountant |
| Anthony Sword | Production Assistant |
| Rosie Smith | Assistant Production Coordinator |
| Breanna Smith | Production Secretary |
| Safka Sintmaartensdijk | Second Assistant Accountant |
| Shauna Sanders | Production Coordinator |
| Matt Rickett | Writers' Assistant |
| Author Queries | Production Assistant |
| Cynthia Phillips | Post Production Accountant |
| Debbie Pearl | Animal Coordinator |
| William Ostroff | Production Assistant |
| Hailey Oltman | Production Assistant |
| Boafoa Offei-Darko | Writers' Assistant |
| Stephanie Noel | Writers' Assistant |
| Halima V. Hudson | Writers' Assistant |
| Josh Montes | Set Production Assistant |
| Luke McFarland | Researcher |
| Jane McCurdy | Aerial Coordinator |
| Cindi Bogard Long | Second Assistant Accountant |
| Jordan Levine | Production Assistant |
| David Lazan | Supervising Art Director |
| Matt Laumann | Set Medic |
| Filza Khan | Second Assistant Accountant |
| Luana Kasych | Production Coordinator |
| Kalid Hussein | Production Assistant |
| Lou Henry | Second Assistant Accountant |
| Maura Gannett | Studio Teacher |
| Dan Edward Fitzgerald V | Production Assistant |
| Daniel Fisch | Production Secretary |
| Jordyn Ferguson | Production Assistant |
| Adam Everett | Production Assistant |
| Kathy Donno | First Assistant Accountant |
| Matt de Villiers | Second Assistant Accountant |
| Meilee Condron | ADR Voice Casting |
| Kyma Collins | Stand In |
| Jamira Cheatham | Second Assistant Accountant |
| Talia Buckberry | Production Secretary |
| Catelynn Brown | Stand In |
| Bill Bouvier | Second Assistant Accountant |
| Jason Bogard | Production Controller |
| Amy Bertone | Production Assistant |
| Daniel Edel Bennaiem | Production Assistant |
| Cassandra Bautista | Intern |
| David M. Atkinson | First Assistant Accountant |
| Lauren Astore | Writers' Assistant |
| Forrest Alsobrook | Production Assistant |
| Arielle Ackerman | Writers' Assistant |
| Mark Alkofer | Studio Teacher |
| Gerald Willard | Driver |
| Laurence Tozzi | Driver |
| Brian Stackhouse | Driver |
| Glenn Ryan Jr | Driver |
| Dave Robling | Transportation Coordinator |
| Grant Roa | Driver |
| Anna Low | Driver |
| Shelly Little Feather | Driver |
| Eleanor Lefever | Driver |
| Ron Kunecke | Transportation Captain |
| Saul Correa | Driver |
| John Agnew | Driver |
| Renetta G. Amador | Script Supervisor |
| Julie Pearce | Music Editor |
| Tracy McKnight | Music Consultant |
| Neal Prosansky | Location Manager |
| Velvet Graves | Assistant Location Manager |
| Anthony Balderamos | Assistant Location Manager |
| Matt Bolin | Assistant Location Manager |
| Lori A. Balton | Location Scout |
| Amanda Weir | Post Production Coordinator |
| Yvonne Valdez | Assistant Editor |
| Terilyn A. Shropshire | Additional Editor |
| Storm Nylen | Post Production Assistant |
| Laura Minto | Post Production Coordinator |
| Lara Mazzawi | 3D Editor |
| Michelle Lockett | Post Production Assistant |
| Paul Alderman | First Assistant Editor |
| Iman Ahad | Post Production Assistant |
| Jenny Rushton | Costumer |
| Natasha Romanow | Set Costumer |
| Carol Quiroz | Key Costumer |
| Jill Paz | Costume Assistant |
| Amy Parris | Assistant Costume Designer |
| Jessie Noakes | Costumer |
| Melanie Miranda | Set Costumer |
| Mustapha Mimis | Set Costumer |
| Rewa Lewis | Costumer |
| Susan Lee | Costumer |
| Annie Laoparadonchai | Costumer |
| Saascha Wiki Kessell | Costumer |
| Melissa Antablin | Costumer |
| Lori Harris | Set Costumer |
| Sarah Goodhue | Set Costumer |
| Edward Luis Garcia | Costume Assistant |
| Angelina Ciulik | Costume Assistant |
| Marta Bialy | Costumer |
| Marta Bialy | Costume Assistant |
| Dixie Webster | Extras Casting |
| Stacey Pianko | Casting Associate |
| Msaada Nia | Casting Assistant |
| Barbara Harris | ADR Voice Casting |
| Scott Philip Goergens | Casting Associate |
| Shawn Miller | Lead Animator |
| David Paté | Lead Animator |
| Terence Bannon | Animation Supervisor |
| Terry Zumalt | Lighting Technician |
| Dustin VonLossberg | Grip |
| Tony Thompson | Drone Pilot |
| Brent Studler | Electrician |
| Sophie Shellenberger | Lighting Technician |
| Dan Schroer | Second Assistant "A" Camera |
| Paul Santoni | First Assistant "A" Camera |
| Kyle Pugsley | Grip |
| Juan Morse | Lighting Technician |
| Daisuke Dice Miyake | Grip |
| Roger Meilink | Rigging Gaffer |
| Len Levine | Chief Lighting Technician |
| Tony Keddy | Key Grip |
| Farisai Bruce Kambarami | Camera Loader |
| Chris Hults | Lighting Technician |
| James J. Hughes | Grip |
| Conrad Hawkins | Grip |
| Scott Hatley | Grip |
| Quinn Grove | Grip |
| Kurt Grossi | Key Grip |
| Shun Goldin | Grip |
| James Ginn | Assistant Chief Lighting Technician |
| Jason Gary | Best Boy Grip |
| Kirk R. Gardner | Steadicam Operator |
| Melissa Fisher | Second Assistant "B" Camera |
| Roger Feenstra | Aerial Director of Photography |
| Kevin Erb | Key Rigging Grip |
| Andy DePung | First Assistant "C" Camera |
| Keith B. Davis | First Assistant "B" Camera |
| John Curran | Grip |
| Grant Culwell | Steadicam Operator |
| Kevin Constant | Additional Photography |
| Jonathan Clark | Additional Second Assistant Camera |
| Denise Brady | Rigging Grip |
| Laetitia Belen | Second Assistant "B" Camera |
| Jesse Beaird | Grip |
| Min Windle | Stunt Coordinator |
| Lavern Whitt | Stunt Double |
| Hayley Stent | Utility Stunts |
| David Schultz | Utility Stunts |
| Stephen W. Schriver | Stunt Double |
| Eric Salas | Utility Stunts |
| J.C. Robaina | Utility Stunts |
| Stephen A. Pope | Stunt Coordinator |
| David Pope | Utility Stunts |
| Heidi Pascoe | Stunts |
| Heidi Pascoe | Stunt Double |
| Casey O'Neill | Utility Stunts |
| Noelle Therese Mulligan | Utility Stunts |
| Michael McGuire | Utility Stunts |
| Tara Macken | Stunt Double |
| Marcia Lopez Aleman | Utility Stunts |
| Bethany Levy | Utility Stunts |
| Andrea Kinsky | Utility Stunts |
| Oz Kalvan | Stunt Double |
| Antal Kalik | Stunt Double |
| Jesse Jacobs | Stunts |
| Jesse Jacobs | Utility Stunts |
| Sierra Hoyle | Stunt Double |
| Brian T. Hewitt | Utility Stunts |
| Shane Habberstad | Utility Stunts |
| Will Greenburg | Utility Stunts |
| Travis Fienhage | Utility Stunts |
| Kofi Elam | Utility Stunts |
| Joey Dickey | Utility Stunts |
| Arturo Dickey | Utility Stunts |
| Rockey Dickey Jr. | Utility Stunts |
| Conner Deadrick | Utility Stunts |
| Peter Croft | Utility Stunts |
| Bryan Cartago | Utility Stunts |
| Nitasha Bhambree | Stunt Double |
| Hannah Betts | Utility Stunts |
| Matt Berberi | Utility Stunts |
| Jenna Yu | Compositing Supervisor |
| Joshua Young | Compositor |
| Michael Yates | Compositor |
| Nick Whiteley | Compositing Supervisor |
| Brittany Wetzel | Compositor |
| Pablo Wang | Digital Compositor |
| Sagar Wakankar | Digital Compositor |
| James Wakelin | Visual Effects Coordinator |
| Jack Van Nuis | Compositor |
| Nilesh Uttarwar | Compositor |
| Johnne Tyson | Compositor |
| Chris W. Tucker | Visual Effects Coordinator |
| Sara Tremblay | Compositor |
| Will Towle | Digital Compositor |
| Joel Tong | Digital Compositor |
| Blaine Toderian | Lead Animator |
| Patrick Thompson | Digital Compositor |
| Connie Sung | Visual Effects Coordinator |
| Sina Sultani | Visual Effects Coordinator |
| C.C. Srinivasan | Compositor |
| Gabriel Souza | Compositor |
| Paul Song | Visual Effects |
| Jason Selfe | Compositor |
| Paul Schmitke | Visual Effects |
| Sean Santiago | Visual Effects Producer |
| Soumyanath Samith | Compositor |
| Shiv Sairam | Compositor |
| Preetam Saha | Digital Compositor |
| Nema Safvati | Visual Effects |
| Harikrishna S | Digital Compositor |
| Mikaiel Russ | Compositor |
| Vania Ruano | Digital Compositor |
| Robert Rossello | Compositor |
| Mark Rice | Compositing Supervisor |
| Andrew Rhinehart | Compositing Supervisor |
| Rachael Catherine Pilas | Production Assistant |
| Britni Ziegler Peters | Visual Effects Editor |
| Amanda Ninness | Visual Effects Coordinator |
| Sujeen Nepali | Digital Compositor |
| Kenneth Nelson | Visual Effects Supervisor |
| Paresh Navlakha | Digital Compositor |
| Patrizia Mulè | Visual Effects Coordinator |
| Matthew Mullarkey | Digital Compositor |
| Llewellyn Littlemore | Production Assistant |
| Megan Kuntz | Digital Compositor |
| Shivani Jhaveri | Visual Effects Coordinator |
| M Quinn | Special Effects Technician |
| Kira Peacock | Special Effects Assistant |
| Joe Love | Special Effects Technician |
| Mark Hawker | Special Effects Supervisor |
| Wes Hannah | Special Effects Technician |
| Victoria Haag | Special Effects Assistant |
| Paul Dane | Special Effects Technician |
| Leslie Coogan | Special Effects Technician |
| Qianbaihui Yang | Foley Supervisor |
| Geoff Vaughan | Foley Artist |
| Jana Vance | Foley Artist |
| Dennie Thorpe | Foley Artist |
| Douglas Shamburger | Boom Operator |
| John Roesch | Foley Artist |
| Jacob Riehle | Dialogue Editor |
| Kimberly Patrick | Foley Editor |
| Al Nelson | Supervising Sound Editor |
| Lucas Miller | Assistant Sound Editor |
| Al Nelson | Sound Designer |
| Kyrsten Mate | Sound Effects Editor |
| Chris Manning | Foley Editor |
| Evan Kishiyama | Sound Recordist |
| Scott Guitteau | Sound Effects Editor |
| Pascal Garneau | Sound Effects Editor |
| Andre Fenley | Supervising Sound Editor |
| Blake Collins | Foley Mixer |
| Patrick Christensen | ADR Mixer |
| David Chrastka | Sound Effects Editor |
| Willie D. Burton | Sound Mixer |
| Stephanie Brown | Dialogue Editor |
| Marco Alicea | Assistant Sound Editor |
| Ben Woodworth | Painter |
| Michael Vojvoda | Set Dresser |
| Sarai Sosa | Set Dresser |
| Rafael Somarriba | Set Dresser |
| Regana Redd | On Set Dresser |
| Eric Ramsey | Storyboard Artist |
| Heidi Pieh | Set Decoration Buyer |
| Andrea Onorato | Assistant Art Director |
| Connor Morris | Painter |
| David Masson | Concept Artist |
| Joshua Min | Concept Artist |
| Jim Magdaleno | Storyboard Artist |
| Lianir Lopez | Set Decoration Buyer |
| Danielle Lee | Art Department Assistant |
| Didier Konings | Concept Artist |
| Danielle Lee | Art Department Coordinator |
| J.P. Jones | Property Master |
| Benton Jew | Storyboard Artist |
| Sean D. Jackson | Set Dresser |
| Ben Grangereau | Concept Artist |
| John Fox | Storyboard Artist |
| Henry Fong | Concept Artist |
| Warren Drummond | Storyboard Artist |
| Danelle Davenport | Storyboard Artist |
| Court Chu | Concept Artist |
| Rick Chavez | Assistant Property Master |
| Martin Charles | Graphic Designer |
| Lorrie Campbell | Set Designer |
| Robert A. Blackburn | Construction Coordinator |
| Alexandra Belmonte | Concept Artist |
| Nuttavut Baiphowongse | Concept Artist |
| Samantha Avila | Assistant Art Director |
| Joanetta Stowers | Key Makeup Artist |
| Molly Stern | Makeup Artist |
| Mark Starr | Makeup Artist |
| Janeen Schreyer | Makeup Artist |
| Derrick Rutledge | Makeup Artist |
| Lisa Rocco | Makeup Artist |
| Tracey Levy | Makeup Artist |
| Colleen LaBaff | Key Hair Stylist |
| Jasmine Kimble | Key Hair Stylist |
| Whitney James | Makeup Artist |
| Garrett Warren | Stunt Coordinator |
| Daniel Benjamin | Studio Teacher |
