 | Ray Romano als Manny (voice) |
 | John Leguizamo als Sid (voice) |
 | Denis Leary als Diego (voice) |
 | Queen Latifah als Ellie (voice) |
 | Simon Pegg als Buck (voice) |
 | Seann William Scott als Crash (voice) |
 | Josh Peck als Eddie (voice) |
 | Chris Wedge als Scrat (voice) |
 | Karen Disher als Scratte (voice) |
 | Kristen Wiig als Pudgy Beaver Mom (voice) |
 | Eunice Cho als Madison (Diatryma Girl) (voice) |
 | Harrison Fahn als Glypto Boy (voice) |
 | Maile Flanagan als Aardvark Mom (voice) |
| Jason Fricchione als Adult Molehog Male (voice) |
 | Bill Hader als Gazelle (voice) |
 | Kelly Keaton als Molehog Mom / Shovelmouth Mom (voice) |
 | Joey King als Beaver Girl (voice) |
| Lucas Leguizamo als Aardvark Boy / Beaver Kid #2 (voice) |
 | Jane Lynch als Diatryma Mom (voice) |
| Regan Mizrahi als Additional voices / ADR Group |
 | Clea Lewis als Start Mom (voice) |
| Allegra Leguizamo als Aardvark Girl (voice) |
 | Carlos Saldanha als Dinosaur Babies / Flightless Bird (voice) |
 | Claudia Besso als Additional Voice (voice) |
| Bea Miller als Additional Voice / ADR Group (voice) |
| Christian Pikes als Little Johnny (Aardvark Kid) (voice) |
| Avery Christopher Plum als Beaver Kid #1 (voice) |
| Joe Romano als Ronald (Shovelmouth Boy) (voice) |
| Manoela Scarpa Saldanha als Molehog Girl 1 (voice) |
| Sofia Scarpa Saldanha als Molehog Girl 2 (voice) |
| Cindy Slattery als Bird (voice) |
 | Matt Adler als Additional Voice (voice) |
| Steve Alterman als Additional Voice (voice) |
| Anthony Amorim als Additional Voice (voice) |
 | Holly Dorff als Additional Voice (voice) |
 | Nicole Ehinger als Additional Voice (voice) |
| David H. Kramer als Additional Voice (voice) |
 | Selenis Leyva als Additional Voice (voice) |
| Matt McCarthy als Additional Voice (voice) |
 | David McCharen als Additional Voice (voice) |
| Tim Nordquist als Additional Voice (voice) |
 | Devika Parikh als Additional Voice (voice) |
| Alexandra Pisacane als Additional Voice (voice) |
 | Jake Schwencke als Additional Voice (voice) |
| Amanda Scott als Additional Voice (voice) |
 | Johnathan Tchaikovsky als Additional Voice (voice) |
| Pamala Tyson als Additional Voice (voice) |
 | June Christopher als Additional Voice (voice) |
 | Frank Welker als Momma Dino (voice) (uncredited) |
| Michael Berg | Screenplay |
| Carlos Saldanha | Director |
| Peter Ackerman | Screenplay |
| John Powell | Original Music Composer |
| Harry Hitner | Editor |
| John C. Donkin | Producer |
| Lori Forte | Producer |
| Galen T. Chu | Animation Supervisor |
| Melanie Martini | Set Decoration |
| Robert MacKenzie | Color Designer |
| Keith Stichweh | Visual Effects Technical Director |
| Arden Chan | Set Designer |
| Samantha Berg | Production Supervisor |
| Dave Metzger | Orchestrator |
| Kyrsten Mate | Sound Effects Editor |
| Kevin Rucker | Animation |
| Salvatore Melluso | Modeling |
| Sue Fox | Foley Editor |
| Chad N. Walker | Assistant Editor |
| David H. Kramer | ADR Voice Casting |
| Roy Latham | ADR & Dubbing |
| Ryan Denniston | Animation |
| Scott C. Lemmer | Animation |
| Venece Lyman | Animation |
| Kristin Labriola | Animation Department Coordinator |
| Mark Edwards | Creature Technical Director |
| James Gu | Creature Technical Director |
| Melvin Tan | Lead Animator |
| Sophia Ohara | Lighting Production Assistant |
| Brandon Kern | Animation |
| Lluis Llobera | Animation |
| Robin Luera | Animation |
| Motoko Wada | Modeling |
| Clayton Stillwell | Visual Development |
| Taylor Shaw | Visual Effects |
| Baaron Schulte | VFX Artist |
| Yoni Brenner | Screenplay |
| Aaron M. Ross | Sequence Leads |
| Eric Bradley | Musician |
| Alena Wooten | Sculptor |
| Melanie Martini | Set Dresser |
| Denis St. Amand | Score Engineer |
| Jason Fricchione | Editorial Manager |
| Kevin R Daly | Production Coordinator |
| Gina Grasso | Production Coordinator |
| Jacqueline Jones | Production Coordinator |
| Cheryl Nardi | Dialogue Editor |
| George Doering | Musician |
| Kevin Kliesch | Orchestrator |
| Conrad Pope | Orchestrator |
| Andy Conroy | Animation |
| Rylan Davies | Animation |
| Lance Fite | Animation |
| Ryan Glovka | Animation |
| Keith Paciello | Animation |
| Jeff Brodsky | Creature Technical Director |
| Mike Reiss | Screenplay |
| Gianna Orzo | Production Intern |
| Paul Downs | Animation |
| Michael Sabalvaro | Animation |
| Heather Brown | VFX Artist |
| Rick Gould | ADR & Dubbing |
| Wade Culbreath | Musician |
| Michael Eringis | CG Supervisor |
| Dawn Fidrick | Production Intern |
| Fletcher Sheridan | Playback Singer |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Joseph Antonuccio | Animation |
| Paul Diaz | Animation |
| Sheldon Kruger | Animation |
| Michelle Ohana | Animation |
| Ian M. Burkard | Modeling |
| Nathan Wall | Animatronics Supervisor |
| Chris Regan | Color Timer |
| Angie Yesson | Sound Recordist |
| Matthew Doble | Animation |
| Phillip Hall | Animation |
| Min Kang | Animation |
| Jason Martinsen | Animation |
| Brian Menz | Animation |
| Pete Paquette | Animation |
| Alan Rogers | Animation |
| Daveed Kaplan | Modeling |
| Peter DeSève | Character Designer |
| Daniel Patrick O'Brien | Sequence Leads |
| Hans Dastrup | Lead Animator |
| Shaun Cusick | Sculptor |
| Vicki Saulls | Sculptor |
| Marshall Winn | ADR Editor |
| Jana Vance | Foley |
| Thom Roberts | Animation |
| Jason Taylor | Animation |
| David Torres | Animation |
| Christopher Mullins | Animation |
| E. Larry Oatfield | Foley Editor |
| Chris Jolly | VFX Artist |
| Kathryn Durfee | Production Intern |
| Ian Higgenbotham | Production Intern |
| Justine Warwick | Assistant Editor |
| Andrew Coats | Animation |
| Mir Ural Noorata | Animation |
| Robyne Powell | Animation |
| James Palumbo | Co-Editor |
| Kyle Smith | Set Decoration |
| Leif Jeffers | Animation |
| Bryan Useo | CG Supervisor |
| Kevin Estrada | Still Photographer |
| Tom Humber | Set Designer |
| Micah Dahlberg | Casting Associate |
| Edward Robbins | Modeling |
| Chris Wedge | Executive Producer |
| Gates Roberg-Clark | Additional Effects Development |
| Dennie Thorpe | Foley |
| Thomas A. Carlson | Music Editor |
| Peter Clarke | Conceptual Design |
| Ryan Hobbiebrunken | Animation |
| David Sloss | Animation |
| Justin Weg | Animation |
| Kristen Drewski | Animation Production Assistant |
| Brendan Condit | Creature Technical Director |
| Adam Burr | Character Technical Supervisor |
| Erin Crackel | First Assistant Editor |
| Nathan Engelhardt | Animation |
| Aaron Kirby | Animation |
| JP Sans | Animation |
| Cleveland Hibbert | Modeling |
| Dave Strick | Modeling |
| Mike Thurmeier | Co-Director |
| Robert Christian Huth | Animation |
| Randy Thom | Sound Re-Recording Mixer |
| Joe Bonomo | Systems Administrators & Support |
| Amanda Deering Jones | Editorial Coordinator |
| Alexis Jallad | Production Accountant |
| Michael J. Travers | Production Manager |
| Anthony Nisi | Production Supervisor |
| Rick Giovinazzo | Orchestrator |
| John Ashton Thomas | Orchestrator |
| Gwendolyn Yates Whittle | Supervising Sound Editor |
| Abraham Aguilar | Animation |
| Scott Carroll | Animation |
| Eric Johnson | Animation |
| Malcon Pierce | Animation |
| Jason Davies | Creature Technical Director |
| Todd Edward James Hill | Creature Technical Director |
| Ashini Shah | Executive Producer |
| Philip Rogers | ADR & Dubbing |
| Tansal Arnas | Schedule Coordinator |
| Patrick Worlock | Script Supervisor |
| Kaitlin Sullivan | Production Intern |
| David Jordan | Lighting Artist |
| Richard Hymns | ADR Editor |
| Randy Kerber | Orchestrator |
| Dan Barker | Animation |
| Tab Burton | Animation |
| Sean Ermey | Animation |
| Gordana Fersini | Animation |
| Richard A. Fournier | Animation |
| Kyle Mohr | Animation |
| Michael Richard | Animation |
| Gregory Rizzi | Animation |
| Jeff Weidner | Animation |
| Jason Carter Eaton | Story |
| Mark C. Harris | Animation |
| Pete Anthony | Orchestrator |
| Holly Dorff | ADR Voice Casting |
| Adam Green | Animation |
| Valerie Morrison | Animation |
| Derek Rozmes | Animation |
| Casey Dame | Creature Technical Director |
| Adam McMahon | Modeling |
| Michael Knapp | Art Direction |
| Peter Mendonca | ADR & Dubbing |
| Lisa Kalmanson | Visual Effects Technical Director |
| Kathy Graves Toon | Assistant Editor |
| Haji Uesato | Lighting Supervisor |
| Shawn Murphy | Scoring Mixer |
| Mark Kenna | Dolby Consultant |
| Jake Rugino | Production Intern |
| Jeff Almquist | Animation |
| Garrett Shikuma | Animation |
| Van Phan | Animation |
| Ian Etra | Creature Technical Director |
| Greg Anderson | Digital Compositors |
| Brent Wong | Modeling |
| Moroni Taylor | Storyboard Artist |
| Michael Tanzillo | Visual Effects |
| Randy Thom | Sound Designer |
