 | Elliot Page als Sylvia Likens |
 | Catherine Keener als Gertrude Baniszewski |
 | Hayley McFarland als Jennifer Faye 'Jennie' Likens |
 | Nick Searcy als Lester Likens |
 | Romy Rosemont als Betty Likens |
 | Ari Graynor als Paula Baniszewski |
 | Scout Taylor-Compton als Stephanie Baniszewski |
 | Tristan Jarred als Johnny Baniszewski |
 | Hannah Leigh als Shirley Baniszewski |
 | Bradley Whitford als Prosecutor |
 | James Franco als Andy |
 | Scott Eastwood als Eric |
 | Michael O'Keefe als Reverend Bill Collier |
 | Carlie Westerman als Marie Baniszewski |
 | Michelle Benes als Hope Orbach |
 | Jeremy Sumpter als Coy Hubbard |
 | Brian Geraghty als Bradley |
 | Channing Nichols als Patty |
 | Michael Welch als Teddy |
 | Evan Peters als Ricky Hobbs |
 | Amy Ferguson als Sally |
 | Will Carter als Officer Waters |
 | Edward James Gage als Bailiff |
 | Patricia Place als Mrs. Doyle |
 | Paul Grace als Cottin Candy Vendor (uncredited) |
 | James Meehan als Defense Attorney (uncredited) |
| Paul Palo als Newspaper Reporter (uncredited) |
 | Gary Sievers als Carnie (uncredited) |
| John Waters | Thanks |
| Hugh Dancy | Thanks |
| Melissa Kent | Editor |
| Nathan Amondson | Production Design |
| Kirsten Smith | Thanks |
| Alan Ari Lazar | Original Music Composer |
| Pamela Koffler | Executive Producer |
| Jocelyn Hayes | Producer |
| Byron Shah | Director of Photography |
| Tommy O'Haver | Screenplay |
| Tommy O'Haver | Director |
| Tommy O'Haver | Author |
| Michael V. Nicolo | Casting Associate |
| Irene Turner | Screenplay |
| Irene Turner | Author |
| Beau J. Genot | Post Production Supervisor |
| Anya Colloff | Casting |
| Amy McIntyre Britt | Casting |
| Jonathan McCoy | Unit Production Manager |
| Hans Ritter | Co-Producer |
| Chad Rosen | Assistant Director |
| Jan McWilliams | Script Supervisor |
| Daniel Curet | Hair Department Head |
| Scott Stolz | Sound Mixer |
| Zach Bangma | Art Direction |
| Molly O'Haver | Set Costumer |
| Billy Mulligan | Thanks |
| Stuart Burkin | Executive In Charge Of Production |
| David Waine | Special Effects Coordinator |
| Alix Hester | Costume Design |
| Mato | Color Timer |
| Lori Ayala-Read | Costume Supervisor |
| Spring Aspers | Music Supervisor |
| Jorjee Douglass | Makeup Department Head |
| Ed McDermott II | Stunts |
| Lisa Alkofer | Set Decoration |
| Lou Simon | Stunt Coordinator |
| Judy Cook | Casting |
| Carlos A. Aragon | Location Manager |
| Jonathan Bell | Thanks |
| Jeff Clark | Steadicam Operator |
