 | Quvenzhané Wallis als Annie Bennett |
 | Jamie Foxx als William "Will" Stacks |
 | Rose Byrne als Grace Farell |
 | Cameron Diaz als Miss Colleen Hannigan |
 | Bobby Cannavale als Guy |
 | Adewale Akinnuoye-Agbaje als Nash |
 | David Zayas als Lou |
 | Amanda Troya als Pepper |
 | Zoe Colletti als Tessie |
 | Nicolette Pierini als Mia |
 | Eden Duncan-Smith als Isabella |
 | Dorian Missick als Annie's "Dad" |
 | Tracie Thoms als Annie's "Mom" |
 | Mike Birbiglia als Social Services Inspector |
 | Stephanie Kurtzuba als Mrs. Kovacevic |
 | Peter Van Wagner als Harold Gray |
 | Michael J. Fox als Himself |
 | Raushanah Simmons als YaYa L'Occitane |
 | DonnaMarie Recco als Woman on Street |
 | Mila Kunis als Andrea Alvin |
 | Ashton Kutcher als Simon Goodspeed |
 | Rihanna als Moon Goddess |
 | Patricia Clarkson als Focus Group Woman |
 | Sia als Animal Care & Control Volunteer |
 | Bobby Moynihan als Guy In Bar |
 | Pat Kiernan als NY1 Reporter |
 | Beth Rowe als Reporter |
| Jill Nocolini als Ms. Giannetti |
| Brad Bong als Pickle Stevens |
 | Andrew Fleming als Cleve Sweetzer |
| Jessica Sherr als Mary Gillen |
| Scarlett Benchley als Fish Goddess |
 | Ray Iannicelli als Waiter at Domani |
 | Ty Jones als Stacks Mobile Reporter |
 | Victor Cruz als Teacher |
 | Taylor Richardson als Red Haired "Annie" |
 | Derrick Baskin als Auditioning 'Dad' |
 | Pernell Walker als Auditioning 'Mom' |
| Lytle Harper als Domani Reporter |
| J. Kaitlin Becker als Grace's Assistant |
 | Ruby Rose Turner als Orphan #8 (uncredited) |
| Cynthia Basinet als Wealthy mother (uncredited) |
 | Maesi Caes als Orphan #3 (uncredited) |
 | Josh Elliott Pickel als (uncredited) |
 | Lily Peterson als Tessie Photo Double |
 | Patricia Pinto als Mom |
| Francesca Pinto als Friend of foster girls |
 | Alan D. Purwin als Stacks' Pilot |
 | Nicholas Pinto als Friend of foster girls |
 | Bill Walters als Soup Kitchen Guest (uncredited) |
 | Amyrh Harris als Classroom Kid |
 | Gabriella Baldacchino als Classmate (uncredited) |
 | Tate McRae als Orphan #17 (uncredited) |
 | Degenerocity als Kid in Theater (uncredited) |
| Marcia Hinds | Production Design |
| Tia Nolan | Editor |
| Aline Brosh McKenna | Screenplay |
| Will Smith | Producer |
| Will Gluck | Director |
| Jay-Z | Producer |
| Thomas Meehan | Novel |
| Brian Heller | Aerial Director of Photography |
| Michael Grady | Director of Photography |
| Lisa Jaime | Music Editor |
| Sherry Whitfield | Music Editor |
| Renee Ehrlich Kalfus | Costume Design |
| Carlton Kaller | Music Editor |
| Greg Kurstin | Original Music Composer |
| Jon Jordan Dibartolomeo | Key Hair Stylist |
| Jeffrey Wetzel | First Assistant Director |
| Charles Maynes | Sound Effects Editor |
| Darin Moran | Camera Operator |
| Stanley D. Williams | Script Consultant |
| Tyran Smith | Producer |
| Caleeb Pinkett | Producer |
| Victor Paguia | Stunt Coordinator |
| Jody Blose | Script Supervisor |
| Barry Wetcher | Still Photographer |
| Jimmy McBride | Tailor |
| Joanna McCarthy | Key Makeup Artist |
| Jon Wakeham | Supervising Sound Editor |
| Patricia Woodbridge | Art Direction |
| Bill O'Leary | Gaffer |
| Wende Crowley | Music Supervisor |
| Bruce Tanis | Foley Editor |
| David Schlesinger | Set Decoration |
| Louise McCarthy | Makeup Department Head |
| Sha-Sha Shiau | Art Department Coordinator |
| Joel Weaver | Property Master |
| Junior Cyrus Baron | Boom Operator |
| Robert Getty | Dialogue Editor |
| Richie Ford | Rigging Gaffer |
| Dylan Goss | Aerial Director of Photography |
| James Lassiter | Producer |
| Kathleen Chopin | Casting |
| Timothy Metzger | Leadman |
| Ulrika Akander | Supervising ADR Editor |
| Randle Akerson | Sound Effects Editor |
| Lorena Talpan | Visual Effects Editor |
| Tiffany Kirkland | Costume Coordinator |
| Tyson Bidner | Location Manager |
| Jada Pinkett Smith | Producer |
| Mara Alcaly | Location Manager |
| Mitchell Andrew Lillian | Key Grip |
| David Richard Campbell | Orchestrator |
| Dain I. Kalas | Tailor |
| Robert Troy | Dialogue Editor |
| Andrew Priestley | Camera Operator |
| Careen Fowles | Costume Supervisor |
| Will Gluck | Screenplay |
| Maceo Bishop | Steadicam Operator |
| Nathan J. Busch II | Hair Department Head |
| Fred Buchholz | Special Effects Coordinator |
| Al Cerullo | Pilot |
| Martin Charnin | Lyricist |
| Haaron Hines | Stunts |
| Charles Strouse | Music |
| Caroline Vexler | Stunts |
| Deb Dyer | Unit Production Manager |
| Jill Brown | Stunt Driver |
| Shawnna Thibodeau | Stunt Double |
