 | Natalie Portman als Lena |
 | Jennifer Jason Leigh als Dr. Ventress |
 | Gina Rodriguez als Anya Thorensen |
 | Tessa Thompson als Josie Radek |
 | Tuva Novotny als Cass Sheppard |
 | Oscar Isaac als Kane |
 | Benedict Wong als Lomax |
 | Sonoya Mizuno als Katie (Med Student) / Humanoid |
 | David Gyasi als Daniel |
 | John Schwab als Paramedic |
 | Sammy Hayman als Mayer |
 | Josh Danford als Shelley |
 | Kristen McGarrity als Lena Double |
 | Kumud Pant als Scientist (uncredited) |
 | Honey Holmes als Scientist (uncredited) |
 | Hiten Patel als Scientist (uncredited) |
 | Kola Bokinni als Peyton (uncredited) |
 | Cosmo Jarvis als Special Ops Soldier (uncredited) |
 | Matthew Simpson als Special Ops Soldier (uncredited) |
| Alex Garland | Director |
| Jeff VanderMeer | Novel |
| Jo Burn | Executive Producer |
| David Ellison | Executive Producer |
| Dana Goldberg | Executive Producer |
| Don Granger | Executive Producer |
| Andrew Macdonald | Producer |
| Allon Reich | Producer |
| Barney Pilling | Editor |
| Francine Maisler | Casting |
| Mark Digby | Production Design |
| Gareth Cousins | Art Direction |
| Simon Elsley | Art Direction |
| Elaine Kusmishko | Art Direction |
| Michelle Day | Set Decoration |
| Sammy Sheldon | Costume Design |
| Sara Desmond | Unit Production Manager |
| Clare St. John | Post Production Supervisor |
| Matthew Penry-Davey | First Assistant Director |
| Alex Garland | Screenplay |
| Ben Salisbury | Original Music Composer |
| Geoff Barrow | Original Music Composer |
| Lauren Doss | Art Direction |
| Denis Schnegg | Supervising Art Director |
| Samantha Denyer | Makeup Artist |
| Charlotte Rogers | Makeup Artist |
| Niv Adiri | Sound Designer |
| Ben Barker | Sound Designer |
| Danny Freemantle | Sound Effects Editor |
| Glenn Freemantle | Sound Designer |
| Mitch Low | Production Sound Mixer |
| Robert Malone | Sound Effects Editor |
| Ian Tapp | Sound Re-Recording Mixer |
| Austin Aplin | Visual Effects Coordinator |
| Tom Balogh | Visual Effects Editor |
| Tina Richardson | Visual Effects Editor |
| Rob Hardy | Director of Photography |
| Sebastian Lochmann | Makeup Effects |
| Tristan Versluis | Makeup Effects |
| Tristan Versluis | Animatronics Supervisor |
| Sian Grigg | Hair Designer |
| Sian Grigg | Makeup Designer |
| Lauren Briggs-Miller | Assistant Art Director |
| Kira Kemble | Assistant Art Director |
| Muffin Green | Property Master |
| Russell Oxley | Scenic Artist |
| Emanuele Farnesi | 3D Artist |
| Jeremy Stewart | Animation Supervisor |
| Artemis Oikonomopoulou | CG Supervisor |
| Luca Zappala | CG Supervisor |
| Nicolas Hernandez | CG Supervisor |
| Sean Schur | Sequence Supervisor |
| Alyssa Harrison | Visual Effects Coordinator |
| Paul O'Hara | Visual Effects Coordinator |
| Michael Tuohy | Visual Effects Coordinator |
| Erin Langford | Visual Effects Coordinator |
| Agnes Toomus | Visual Effects Coordinator |
| Katia Muscariello | Visual Effects Coordinator |
| Alastair Grimshaw | Visual Effects Editor |
| Dhuha Isa | Visual Effects Editor |
| Jessica Atkinson | Visual Effects Editor |
| Roma O'Connor | Visual Effects Producer |
| Carlos Ciudad | Visual Effects Producer |
| Paul Edwards | Visual Effects Producer |
| Bhumika Mayer | Visual Effects Producer |
| Noga Alon Stein | Visual Effects Producer |
| Andrew Whitehurst | Visual Effects Supervisor |
| Sara Bennett | Visual Effects Supervisor |
| Simon Hughes | Visual Effects Supervisor |
| Amir Manavi | Visual Effects Technical Director |
| Vince McGahon | Steadicam Operator |
| Andy Lowe | Gaffer |
| Chris Georgas | Gaffer |
| Sam Phillips | Key Grip |
| John Antill | Rigging Gaffer |
| Peter Mountain | Still Photographer |
| Rick Woollard | Additional Camera |
| Martin Ware | Casting Associate |
| Poli Kyriacou | Assistant Costume Designer |
| Nicole Young | Costume Supervisor |
| Lucia Foster Found | Aerial Coordinator |
| Tom Ralphs | Armorer |
| Bobbi Jene Smith | Choreographer |
| Will Samuelson | Pilot |
| Jonjo Stickland | Marine Coordinator |
| San Davey | Script Supervisor |
| Victoria Gegenbauer | Script Supervisor |
| Matt Curtis | Title Designer |
| Sarah Clark | Unit Publicist |
| Tim Drewett | Digital Intermediate |
| Gemma Lyons | Digital Intermediate |
| Otto Rodd | Digital Intermediate |
| Andrew Scattergood | Digital Intermediate |
| Ben-Roy Turner | Digital Intermediate |
| Isabel Zippert | Digital Intermediate |
| Emanuele Giraldo | First Assistant Editor |
| Hayley J Williams | Special Effects Supervisor |
| Stephane Malenfant | Boom Operator |
| Gillian Dodders | ADR Supervisor |
| Emilie O'Connor | Dialogue Editor |
| Peter Burgis | Foley |
| Zoe Freed | Foley |
| Lilly Blazewicz | Foley Editor |
| Niv Adiri | Sound Re-Recording Mixer |
| Glenn Freemantle | Supervising Sound Editor |
| Alana Mayo | Thanks |
| Daniel Rogers | Health and Safety |
| Scott Rudin | Producer |
| Eli Bush | Producer |
| Nina Gold | Casting |
| Joanne Smith | Associate Producer |
| Charlie Reed | Second Assistant Director |
| Belinda Parish | Makeup Artist |
| Paul Spateri | Prosthetic Makeup Artist |
| Amie Aspden | Prosthetics Painter |
| Chloe Taylor | Art Department Assistant |
| Ben Johnson | Assistant Property Master |
| Chris Caldow | Concept Artist |
| Elo Soode | Concept Artist |
| Dan Crandon | Construction Manager |
| Michael Pybus | Draughtsman |
| Martin Kane | Dressing Prop |
| Sam Moulsdale | Graphic Designer |
| Gareth Bailey | Props |
| Ryan Bradbury | Props |
| Jed Evans | Props |
| Sean Leishman | Props |
| Natalie Papageorgiadis | Props |
| Stuart Silver | Props |
| Dan Riches | Set Dresser |
| Steve 'Moose' Smith | Set Dresser |
| Lisa McDiarmid | Standby Art Director |
| Mal Zawadzki | Standby Painter |
| Martin Asbury | Storyboard Artist |
| Daniel Addis | Electrician |
| Neil Ashton | Electrician |
| Daniel Chaytor | Electrician |
| Seth Crosby | Electrician |
| Christian Hayes | Electrician |
| Gary Owen | Electrician |
| Pawel Polak | Electrician |
| Andy D. Stewart | Electrician |
| Daniel Stones | Electrician |
| Kai Blamey | Electrician |
| Jennie Paddon | First Assistant "A" Camera |
| Sarah Rollason | First Assistant "B" Camera |
| Paul Allen | Lighting Technician |
| George Anthony Fox | Second Assistant Camera |
| Cenay Said | Second Assistant Camera |
| Matt McNally | Epk Producer |
| Gwilym Morris | Animation Supervisor |
| Tom Rolfe | 2D Supervisor |
| Gena Vazquez | Props |
| Elo Soode | Conceptual Design |
| Jo McLaren | Stunt Coordinator |
| Josh Wood | Carpenter |
| Casey Michaels | Stunt Double |
| Joanne Batten | Stunt Double |
| Chelsea Mather | Stunt Double |
| Belinda McGinley | Stunt Double |
| Karen Teoh | Stunt Double |
| Mens-Sana Tamakloe | Stunt Double |
| Maxine Whittaker | Stunts |
| Pablo Verdejo | Stunts |
| Leo Woodruff | Stunts |
| Martin Wilde | Stunts |
| Martin Pemberton | Stunts |
| Anthony Skrimshire | Stunts |
| Darren Malkin | Stunts |
| Tim Marshall-Rowe | Stunts |
| Niki Faulkner | Stunts |
| Andy Godbold | Stunts |
