 | Denzel Washington als Dr. Jerome Davenport |
 | Derek Luke als Antwone Fisher |
 | Malcolm David Kelley als Antwone Fisher Age 7 |
 | Joy Bryant als Cheryl Smolley |
 | Salli Richardson-Whitfield als Berta Davenport |
 | Leonard Earl Howze als Pork Chop |
 | Kevin Connolly als Slim |
 | Viola Davis als Eva May |
 | Yolonda Ross als Nadine |
 | Gary A. Jones als Relative (uncredited) |
 | Cory Hodges als Antwone Fisher Age 14 |
 | James Brolin als The Captain |
 | Charles Robinson als Howard |
 | Earl Billings als Uncle James |
 | Vernee Watson-Johnson als Aunt Annette |
 | De'Angelo Wilson als Jesse |
 | Stephen Snedden als Berkley |
 | Novella Nelson als Mrs. Tate |
 | Rainoldo Gooding als Grayson |
 | Kente Scott als Kansas City |
| Kim Johnson als Disc Jockey |
 | Sung Kang als Receptionist |
| Denzel Washington | Director |
| Antwone Fisher | Writer |
| Mychael Danna | Original Music Composer |
| Philippe Rousselot | Director of Photography |
| Conrad Buff IV | Editor |
| Nelson Coates | Production Design |
| David Lazan | Art Direction |
| Anne D. McCulley | Set Decoration |
| Sharen Davis | Costume Design |
| Todd Black | Producer |
| Antwone Fisher | Co-Producer |
| Randa Haines | Producer |
| Nancy Paloian | Executive Producer |
| Denzel Washington | Producer |
| Gina White | Associate Producer |
| Chris Smith | Co-Producer |
| Robi Reed | Casting |
| Tierre Turner | Stunt Coordinator |
| Robert Powell | Stunts |
| Dain Turner | Stunts |
| Keith Butler | Stunts |
| Alex Madison | Stunts |
| Tom Waite | Stunts |
| Leigh Shanta | Unit Production Manager |
| Randy Fletcher | First Assistant Director |
| Don Wilkerson | Second Assistant Director |
| Melissa Stanley Cohen | Production Supervisor |
| Molly Allen | Location Manager |
| Doug Moreno | Production Accountant |
| Paul Sonski | Set Designer |
| Barbara Mesney | Set Designer |
| Troy Borisy | Leadman |
| Rocky Slaymaker | Leadman |
| Matt McGuire | Set Dresser |
| Leonard Rothstein | Set Dresser |
| Rod Ledta | Set Dresser |
| Manuel Castillo | Set Dresser |
| Daniel W. Roberts | Set Dresser |
| Diego Sanchez | Set Dresser |
| Warren Drummond | Storyboard Artist |
| Hope R. Goodwin | Second Second Assistant Director |
| Neal Norton | Camera Operator |
| Neal Norton | Steadicam Operator |
| Tony Nagy | First Assistant Camera |
| Don Duffield III | Second Assistant Camera |
| Renee Schuyten | Camera Loader |
| Pamela Rittelmeyer | "B" Camera Operator |
| Xiomara Comrie | First Assistant "B" Camera |
| Rodney Sandoval | Second Assistant "B" Camera |
| Sidney Ray Baldwin | Still Photographer |
| Willie D. Burton | Sound Mixer |
| Marvin E. Lewis | Boom Operator |
| Will Blount | Property Master |
| Monica Castro | Assistant Property Master |
| Matthew C. Kime | Props |
| Annie Welles | Script Supervisor |
| Jack English | Gaffer |
| James Babineaux | Best Boy Electric |
| Stephen Thorp | Electrician |
| Glenn E. Moran | Electrician |
| Erik A. Erichsen | Electrician |
| Chris Shaw | Electrician |
| Stuart Abramson | Key Grip |
| Marc Leeger | Best Boy Grip |
| Arnaud Peiny | Key Rigging Grip |
| Jason Newton | Dolly Grip |
| Seth Greenwald | Dolly Grip |
| Cameron Thorburn | Grip |
| Rick Linkowski | Grip |
| Joe-Joe Presson | Grip |
| Joel A. Ruiz | Rigging Grip |
| Greg Flores | Rigging Grip |
| Billy Beaird | Rigging Grip |
| Thomas Diehl | Libra Head Technician |
| Winnie D. Brown | Costume Supervisor |
| Riki Lin Sabusawa | Costumer |
| Frank Perry Rose | Costumer |
| Yvonne Bastidos | Set Costumer |
| Marylou Lim | Set Costumer |
| Carl Fullerton | Makeup Artist |
| Amrita Diane Ford | Makeup Artist |
| Laini Thompson | Makeup Artist |
| Cat'Ania McCoy-Howze | Makeup Artist |
| Angela Johnson | Makeup Artist |
| Denise Pugh-Ruiz | Makeup Artist |
| Kenneth Walker | Key Hair Stylist |
| Larry M. Cherry | Hairstylist |
| Soo-Jin Yoon | Hairstylist |
| Lynn E. Champagne | Hairstylist |
| Fay Kelly | Hairstylist |
| Pauletta O. Lewis | Hairstylist |
| Kei Rowan-Young | Assistant Location Manager |
| Ann Christman | Production Coordinator |
| Carrie Black Gallison | Assistant Production Coordinator |
| Martin Bresin | Special Effects Coordinator |
| David A. Poole | Special Effects |
| Marvin Felton | Special Effects |
| Lars Petersen | Construction Coordinator |
| Steven C. Voll | Construction Foreman |
| Al Lewis | Art Department Assistant |
| Karen Scarborough | Payroll Accountant |
| Doran Reed | Casting Associate |
| Donna R. Harrison | Casting Assistant |
| Cid Swank | Unit Publicist |
| Wayne Williams | Transportation Coordinator |
| John A. Brubaker | Transportation Captain |
| Warren Paeff | Additional Editing |
| Carole A. Kenneally | First Assistant Editor |
| Jennifer Calbi | Assistant Editor |
| Daniel Kupresan | Assistant Editor |
| Sol Rivera | Craft Service |
| Annette Moreno | Craft Service |
| Donald Sylvester | Supervising Sound Editor |
| James Bolt | Sound Re-Recording Mixer |
| Anna Behlmer | Sound Re-Recording Mixer |
| Dave Kulczycki | Sound Effects Editor |
| Matt Patterson | Sound Recordist |
| William Stein | Sound Engineer |
| Charleen Richards-Steeves | ADR Mixer |
| David Lucarelli | ADR Recordist |
| Steve F. Price | Foley Editor |
| Alicia Stevenson | Foley Artist |
| Dawn Fintor | Foley Artist |
| David Betancourt | Foley Mixer |
| Mildred Iatrou | Dialogue Editor |
| Adam Milo Smalley | Music Editor |
| Nicholas Dodd | Orchestrator |
| Nicholas Dodd | Conductor |
| Paul Intson | Music Programmer |
