 | Sam Worthington als Jake Sully |
 | Zoe Saldaña als Neytiri |
 | Sigourney Weaver als Kiri / Dr. Grace Augustine |
 | Britain Dalton als Lo'ak |
 | Stephen Lang als Colonel Miles Quaritch |
 | Jack Champion als Miles 'Spider' Socorro |
 | Cliff Curtis als Tonowari |
 | Kate Winslet als Ronal |
 | Joel David Moore als Norm Spellman |
 | CCH Pounder als Mo'at |
 | Edie Falco als General Frances Ardmore |
 | Brendan Cowell als Mick Scoresby |
 | Jemaine Clement als Dr. Ian Garvin |
 | Jamie Flatters als Neteyam |
 | Trinity Bliss als Tuk |
 | Bailey Bass als Tsireya |
 | Filip Geljo als Aonung |
 | Duane Evans Jr. als Rotxo |
 | Giovanni Ribisi als Parker Selfridge |
 | Dileep Rao als Dr. Max Patel |
 | Matt Gerald als Recom Wainfleet |
 | Robert Okumu als Ta'unui Olecthan |
 | Jennifer Stafford als Ta'unui Tsahik |
 | Keston John als Tarsem |
 | Kevin Dorman als Recom Mansk |
 | Alicia Vela-Bailey als Recom Zdinarsik |
 | Sean Anthony Moran als Recom Fike |
 | Andrew Arrabito als Recom Prager |
 | Johnny Alexander als Recom Ja |
| Kim Do als Recom Zhang |
| Victor T. Lopez als Recom Lopez |
 | Maria Walker als Recom Walker |
 | Phil Brown als Stringer |
 | Jocelyn Christian als Bio Lab Tech |
 | Joel Tobeck als Neuroscientist |
| Moana Ete als Female Med-Tech |
 | Phil Peleton als Male Med-Tech |
 | Jamie Landau als Metkayina Warrior |
| Jim Moore als Mako Sub #1 Pilot |
 | Benjamin Hoetjes als Mako Sub #1 Gunner |
| Nikita Tu Bryant als Mako Sub #2 Pilot |
 | Anthony Ahern als Mako Sub #2 Gunner |
 | Shane Rangi als Matador Co-Pilot |
| Rick Lucas als Kestrel Pilot |
 | Tanya Drewery als Neurotech #1 |
 | Ava Diakhaby als Neurotech #2 |
| Isaac Te Reina als Sea Dragon First Mate |
| Eric Farmer als Crabsuit Pilot |
| Philip Mtambo als Skel Trooper |
| Daniel Lough als Spider Double |
| Cruz Moir als Young Spider |
| Alex Lucas als Toddler Spider |
 | Scarlett Fernandez als Young Kiri |
 | Chloe Coleman als Young Lo'ak |
 | Jeremy Irwin als Young Neteyam |
 | Jake McLean als Na'vi (uncredited) |
 | CJ Jones als Metkayina Interpreter (uncredited) |
| Stephen E. Rivkin | Editor |
| David Valdes | Executive Producer |
| David Valdes | Unit Production Manager |
| Josh Friedman | Story |
| Christopher Boyes | Sound Designer |
| Christopher Boyes | Supervising Sound Editor |
| Christopher Boyes | Sound Re-Recording Mixer |
| James Horner | Main Title Theme Composer |
| James Cameron | Screenplay |
| James Cameron | Director |
| James Cameron | Editor |
| James Cameron | Producer |
| James Cameron | Characters |
| James Cameron | Story |
| David Brenner | Editor |
| Shane Salerno | Story |
| Margery Simkin | Casting |
| Russell Carpenter | Director of Photography |
| Deborah Lynn Scott | Costume Design |
| Jon Landau | Producer |
| Kim Sinclair | Supervising Art Director |
| Richard Bluck | Second Unit Director of Photography |
| Richard Bluck | Additional Director of Photography |
| Simon Bright | Art Direction |
| Daren Hicks | Production Supervisor |
| John Refoua | Editor |
| Ken Turner | Art Direction |
| Rick Jaffa | Screenplay |
| Rick Jaffa | Story |
| Amanda Silver | Screenplay |
| Amanda Silver | Story |
| Luke Freeborn | Supervising Art Director |
| Lauren Mary Kim | Stunts |
| Andy McLaren | Art Direction |
| Brad Martin | Stunts |
| Kevin Loo | Set Designer |
| Garrett Warren | Stunt Coordinator |
| Garrett Warren | Second Unit Director |
| Dylan Cole | Production Design |
| Richard Baneham | Executive Producer |
| Richard Baneham | Second Unit Director |
| Evan Webber | Set Designer |
| Anne Costa | Assistant Art Director |
| Stephen Christensen | Art Direction |
| Jon Glover | Researcher |
| Ben Procter | Production Design |
| Frankie Karena | Hair Supervisor |
| Stacey Pianko | Casting Associate |
| Robert Bavin | Art Direction |
| Brian Adler | Visual Effects |
| Ross Perkin | Set Designer |
| Denny Caira | Transportation Coordinator |
| Gwendolyn Yates Whittle | Supervising Sound Editor |
| David Chrastka | Sound Effects Editor |
| Lena Scanlan | Visual Effects Producer |
| Brigitte Yorke | Associate Producer |
| Eric Saindon | Visual Effects Supervisor |
| Stuart Thorp | Stunt Coordinator |
| Emily Egge | Costume Supervisor |
| Shari Ratliff | Set Designer |
| Joe Letteri | Visual Effects Supervisor |
| Carrie Bauer | Costume Supervisor |
| Gia Jimenez | Set Costumer |
| Gary Summers | Sound Re-Recording Mixer |
| Sam Storey | Art Direction |
| Jeffrey Beck | Set Designer |
| Andrew Arrabito | Military Consultant |
| Walter Garcia | Visual Effects Producer |
| Steve Gallagher | Music Editor |
| Tyra Youland | Ager/Dyer |
| Franca Gallo | Makeup Artist |
| Kenny Sheard | Stunts |
| Daniel Barrett | Animation Supervisor |
| Andrew Chan | Art Direction |
| Amber Richards | Set Dresser |
| The Weeknd | Songs |
| Nat Van Halle | Set Costumer |
| Ed Symon | Set Designer |
| Chris Silcox | Stunts |
| Heidi Moneymaker | Stunts |
| Michele Perry | Makeup Artist |
| Steven Light-Orr | Art Direction |
| CJ Jones | Other |
| Simon Franglen | Original Music Composer |
| Brian Barela | Set Costumer |
| Aashrita Kamath | Supervising Art Director |
| Kevin A. Canamar | Set Medic |
| Jack Taggart | Ager/Dyer |
| Vinnie Ashton | Key Hair Stylist |
| Cody Dysart | Makeup Artist |
| Shay Lawrence | Key Makeup Artist |
| Andrew Kattie | Set Designer |
| Alasdair Mott | Set Designer |
| Michael Krehl | Tattoo Designer |
| Alister Baxter | Art Direction |
| Brendon Sweeney | Set Designer |
| Colette Mullin | Set Designer |
| Travis Brady | Grip |
| Salim Bensrhir | Gaffer |
| Rudie Schaefer | Art Direction |
| Simeon Jones | Second Assistant Director |
| Ben Milsom | Art Direction |
| Daniel McGraw | Visual Effects |
| Ben Whale | Set Dresser |
| Yvonne Yip | Set Designer |
| Sarah Delucchi | Art Direction |
| Sarah Delucchi | Assistant Art Director |
| Maria Battle Campbell | Associate Producer |
| Maria Battle Campbell | First Assistant Director |
| Rewa Lewis | Set Costumer |
| Amy Wright | Set Costumer |
| Marina Stojanovic | Set Designer |
| Vanessa Cole | Set Decoration |
| Don Brooker | Prosthetics |
| John Ternent | Set Dresser |
| Catharine Stuart | Set Costumer |
| Virginia Berg | Assistant Art Director |
| Joe Howes | Visual Effects |
| Rebecca Asquith | Set Designer |
| Katie Fox-Heywood | Makeup Artist |
| Daniel Koene | Set Designer |
| Carly Marr | Makeup Artist |
