 | Steve Carell als David Sheff |
 | Timothée Chalamet als Nic Sheff |
 | Maura Tierney als Karen Barbour |
 | Amy Ryan als Vicki Sheff |
 | Christian Convery als Jasper Sheff |
 | Oakley Bull als Daisy Sheff |
 | Kaitlyn Dever als Lauren |
 | Stefanie Scott als Julia |
 | Julian Works als Gack |
 | Jack Dylan Grazer als 12-Year-Old Nic Sheff |
 | Zachary Rifkin als 8-Year-Old Nic Sheff |
 | Kue Lawrence als 5-Year-Old Nic Sheff |
 | Timothy Hutton als Dr. Brown |
 | Amy Forsyth als Diane |
 | Andre Royo als Spencer |
 | Ricky Low als Destiny |
 | LisaGay Hamilton als Rose |
 | Carlton Wilborn als Vince |
 | Amy Aquino als Annie Goldblum |
 | Marypat Farrell als Julia's Mother |
 | Brandon James Cienfuegos als Kid |
 | Cheska Corona als Kid |
 | Mandeiya Flory als Kid |
 | Martha T. Newman als Flight Attendant |
 | Minerva García als Nurse @ Bellevue |
 | Nikki Snipper als Airline Attendant |
 | Anastasia Leddick als Speaker @ 12 Step Meeting |
 | Edward Fletcher als Minister |
 | Justin Townes Earle als Wedding Guest |
 | Seann Gallagher als Father @ Graduation |
 | Brooklin Thacher als Principal @ Graduation |
 | Sasha Kelly Jackson als EMT |
 | Tom Beyer als Meeting Leader |
 | David Mendenhall als Rocker (uncredited) |
| Felix van Groeningen | Director |
| Luke Davies | Screenplay |
| Nic Sheff | Book |
| Brad Pitt | Producer |
| Dede Gardner | Producer |
| Jeremy Kleiner | Producer |
| Nan Morales | Executive Producer |
| Francine Maisler | Casting |
| Ethan Tobman | Production Design |
| Patrick M. Sullivan | Art Direction |
| Jennifer Lukehart | Set Decoration |
| Emma Potter | Costume Design |
| Jennifer Bell | Hairstylist |
| Kristen Kirchen | Hairstylist |
| Robert Mrazik | Hairstylist |
| George Bamber | First Assistant Director |
| Gabe Hilfer | Music Supervisor |
| Nancy Au | Costume Supervisor |
| Ruben Impens | Director of Photography |
| Nico Leunen | Editor |
| Felix van Groeningen | Screenplay |
| David Sheff | Book |
| Sarah Esberg | Executive Producer |
| Jean Ann Black | Makeup Department Head |
| Rolf John Keppler | Makeup Artist |
| Elisa Marsh | Makeup Artist |
| Mitchell S. Drain | Visual Effects Supervisor |
| Ulrika Akander | ADR Supervisor |
| Ulrika Akander | Supervising Sound Editor |
| Marc Glassman | Sound Effects Editor |
| Elmo Weber | Sound Re-Recording Mixer |
| Elmo Weber | Sound Designer |
| Elmo Weber | Supervising Sound Editor |
| Nan Morales | Unit Production Manager |
| Adam Cuthbert | Second Assistant Director |
| Marsha L. Swinton | Co-Producer |
| Mark Norby | Stunt Coordinator |
| Michael T. Brady | Marine Coordinator |
| Rocky Capella | Utility Stunts |
| Nancy Kirhoffer | Post Production Supervisor |
| Will Blount | Property Master |
| Martin Milligan | Assistant Property Master |
| Don Bracken | Assistant Property Master |
| Jefferson Murff | Leadman |
| Erik Soderstrom | Set Dresser |
| Don Elliott | Set Dresser |
| Mike Cutler | Set Dresser |
| Molly Hunter Flick | Art Department Coordinator |
| Aric Cheng | Set Designer |
| Ernie Avila | Set Designer |
| John Berger | Set Designer |
| Adee Serrao | Graphic Designer |
| Karen Teneyck | Graphic Designer |
| Kelly Richardson | Stunt Driver |
| Alexander Smith | Stunt Driver |
| Clay Cullen | Stunt Double |
| Gavin Frank | Stunt Double |
| Jeff Porter | First Assistant "A" Camera |
| Sarah Brandes | Second Assistant "A" Camera |
| Jody Miller | "A" Camera Operator |
| Jody Miller | Steadicam Operator |
| Lonny Danler | Digital Imaging Technician |
| David 'Goldy' Goldsmith | Video Assist Operator |
| Lisa Pinero | Production Sound Mixer |
| Randall L. Johnson | Boom Operator |
| Daniel Quintana | Utility Sound |
| Brian Bartolini | Gaffer |
| Roger Awad | Best Boy Electric |
| Toby LeCheminant | Rigging Gaffer |
| Jordan Lapsansky | Electrician |
| Joel Potter | Electrician |
| Johnny Madison | Electrician |
| Josh Allen | Electrician |
| Steve Hughes | Electrician |
| Jesse Austin | Electrician |
| Les T. Tomita | Key Grip |
| Dana Baker | Best Boy Grip |
| Alan Shultz | Dolly Grip |
| Jack Glenn | Grip |
| Daisuke Dice Miyake | Grip |
| Jerry Bertolami | Grip |
| Parker Shultz | Grip |
| Allen Liu | Grip |
| Brandon Jeffrey Harris | Rigging Grip |
| Brian Bishop | Rigging Grip |
| John Ziegler | Special Effects Coordinator |
| Ryan Meinardus | Special Effects Technician |
| Sara Walbridge | Key Costumer |
| Bob Moore Jr. | Costumer |
| Rachael Ohman | Costumer |
| Lauren Morelli | Costumer |
| Lori Harris | Costumer |
| Fríða Aradóttir | Hair Department Head |
| Rita Troy | Key Hair Stylist |
| Barry L. Caldwell | Script Supervisor |
| Steev Beeson | Production Accountant |
| John Panzarella | Location Manager |
| Leslie Thorson | Location Manager |
| Mark Gaffney | Assistant Location Manager |
| Ryan Hintz | First Assistant Accountant |
| Leia Parker | Second Assistant Accountant |
| Nedda Azizian | Second Assistant Accountant |
| Steve Trombatore | Payroll Accountant |
| Jules Carideo | Production Coordinator |
| Jennifer Zolten Freed | Post Production Accountant |
| Cathy Gurvis | Post Production Accountant |
| Meg Norton | Post Production Accountant |
| Vincent Befi | Assistant Production Coordinator |
| Holly Dellocono | Production Secretary |
| Natalie Borlaug | Travel Coordinator |
| Alana Katzner | Second Second Assistant Director |
| Amber Wakefield | Casting Associate |
| Lauren Richer | Casting Assistant |
| Rich King | Background Casting Director |
| Rob Swanson | Background Casting Director |
| Kevin Maier | Stand In |
| François Duhamel | Still Photographer |
| Millie Hirsch | Studio Teacher |
| Michael Diersing | Construction Coordinator |
| Nazia Khan | Producer's Assistant |
| Christina Oh | Producer's Assistant |
| Thomas White | Construction Foreman |
| Michele Faretta | Painter |
| Hector Hernandez | Painter |
| Jeremy Turley | Paint Coordinator |
| Frank McEldowney | Greensman |
| Daniel McEldowney | Greensman |
| Billy Ray Hass | Transportation Coordinator |
| Casey Boden | Transportation Captain |
| Mark A. James | Transportation Co-Captain |
| Dave Kasubowski | Craft Service |
| David Marks | Additional Editing |
| Traci Duran | Additional Editing |
| Traci Duran | First Assistant Editor |
| Chelsea Dinsdale | First Assistant Editor |
| Bernie E. Gomez | Assistant Editor |
| Andrey Ragozin | Assistant Editor |
| David Townsend | Post Production Coordinator |
| John Walek | Post Production Assistant |
| Jeremy Peirson | Sound Re-Recording Mixer |
| Robert Troy | Dialogue Editor |
| Michael Hertlein | Dialogue Editor |
| Cameron Steenhagen | Dialogue Editor |
| Jon Michaels | Foley Editor |
| Catherine Harper | Foley Artist |
| Katherine Rose | Foley Artist |
| Darrin Mann | Foley Mixer |
| Matthew P. Hanson | Assistant Sound Editor |
| Jason Oliver | ADR Recordist |
| Phil Lee | Sound Mix Technician |
| Brent Brooks | Music Editor |
| Henry van Roden | Music Coordinator |
| Molly Pabian | Visual Effects Producer |
| Gabriel Vargas | Digital Effects Supervisor |
| Eric Schoellnast | CG Supervisor |
| Karina Benesh | Visual Effects Coordinator |
| Djochoua Belovarski | Visual Effects Coordinator |
| Ryan Andersen | Visual Effects Editor |
