 | Richard Steven Horvitz als Billy / Billybot / Harold / Pale Ghoulish Juror / Chippy the Squirrel (voice) (as Richard Horvitz) |
 | Grey DeLisle als Mandy / Mandroid / Older Mandy / Milkshakes / Some Kid (voice) |
 | Greg Eagles als Grim / Sperg / Pirate #6 |
 | Vanessa Marshall als Irwin / Pirate #5 / Unicorn (voice) |
 | Maxwell Atoms als I'll Cut You Guy / Pirate #2 / Horrorbot / Burnt Skeleton Guard (voice) |
 | George Ball als Peequay (voice) |
 | Jane Carr als Bride of Frankenstein (voice) |
 | Greg Ellis als Creeper / Horror's Hand / Pirate #3 / Paperboy (voice) |
| Bart Flynn als Giant Cyclops / Ugly Pirate (voice) |
 | C.H. Greenblatt als Fred Fredburger / Pirate #4 (voice) |
 | Jennifer Hale als Billy's Mom (voice) |
 | Dorian Harewood als Older Irwin (voice) |
 | Phil LaMarr als Space Villain / Glacier of Evil / Dracula / Judge Roy Spleen / Underworld Cop (voice) |
 | Rachael MacFarlane als 2 Headed Parrot (voice) |
 | George Segal als Horror (voice) |
 | Armin Shimerman als General Skarr / Pirate #7 (voice) |
| James Silverman als Executioner / Pirate #1 (voice) |
 | Lauren Tom als Numbuh Three (voice) |
 | Billy West als Pirate #8 / Miniature Cyclops / Spider Clown Mailman / Beast Master (voice) |
 | Fred Willard als The Boogey Man (voice) |
| Hyung-tae Kim | Animation Director |
| Louis J. Cuck | Producer |
| Phil Cummings | Director |
| Pietro Piumetti | Producer |
| Jennifer Pelphrey | Producer |
| Brad Brock | Sound Re-Recording Mixer |
| Rob Desales | Editor |
| Michel Lyman | Director |
| Frank Homiski | Characters |
| Robert Alvarez | Director |
| Jim Hearn | Dialogue Editor |
| Azariah Owens | Visual Effects |
| Matt Engstrom | Director |
| Kris Zimmerman | Casting |
| Joe Binggeli | Characters |
| Jay Bastian | Executive In Charge Of Production |
| Eric Sequeira | Sound Re-Recording Mixer |
| Phil Rynda | Color Designer |
| Joo-Shik Yoo | Animation Director |
| Cliff Voorhees | Background Designer |
| Eva Wu | Characters |
| Antonio Gonella | Supervising Technical Director |
| Russell Calabrese | Director |
| Gregory Hinde | Music |
| Illya Owens | Editor |
| James Silverman | Production Manager |
| Mark Bachand | Prop Maker |
| Gordon Kent | Director |
| Jesse Aruda | Sound Editor |
| Sandy Benenati | Animation |
| Kris Sherwood | Director |
| Tony Tedford | Post Production Supervisor |
| Glenn Oyabe | Sound Editor |
| Don Watson | Background Designer |
| Alicia Parkinson | Post Production Supervisor |
| Shalonda Ware | Production Accountant |
| Marc Perry | Characters |
| Eddy Houchins | Director |
| Soo-hyun Park | Animation Director |
| Brian A. Miller | Executive Producer |
| Marc Perry | Art Direction |
| Shaun Cashman | Producer |
| Shaun Cashman | Director |
| Christine Kolosov | Director |
| Sue Perrotto | Director |
| Drew Neumann | Music |
| Anna Chambers | Prop Maker |
| Kwang-bae Park | Animation Director |
| Lee Jae Bok | Animation Director |
| Timothy J. Garrity | Sound Re-Recording Mixer |
| Robert Serda | Sound Engineer |
| Ben Pile | Producer |
| Maxwell Atoms | Characters |
| Maxwell Atoms | Executive Producer |
| Kris Zimmerman | Sound Director |
| Jay Baker | Storyboard Artist |
| Tara Whitaker | Storyboard Artist |
| Spencer Laudiero | Storyboard Artist |
| Shaun Cashman | Storyboard Artist |
| Mike Diederich | Storyboard Artist |
| Maxwell Atoms | Storyboard Artist |
| John Holmquist | Storyboard Artist |
| Ian Wasseluk | Storyboard Artist |
| Chris Mitchell | Storyboard Artist |
| Chris Headrick | Storyboard Artist |
| C.H. Greenblatt | Storyboard Artist |
| Alex Almaguer | Storyboard Artist |
| Joe Binggeli | Background Designer |
| Juli Murphy | Director |
| Phil Rynda | Characters |
| Maxwell Atoms | Story |
| Maxwell Atoms | Writer |
| Nina Bargiel | Writer |
| Jeremy J. Bargiel | Writer |
| Bill Flores | Background Designer |
