 | Amy Poehler als Joy (voice) |
 | Lewis Black als Anger (voice) |
 | Phyllis Smith als Sadness (voice) |
 | Tony Hale als Fear (voice) |
 | Liza Lapira als Disgust (voice) |
 | Maya Hawke als Anxiety (voice) |
 | Ayo Edebiri als Envy (voice) |
 | Adèle Exarchopoulos als Ennui (voice) |
 | Paul Walter Hauser als Embarrassment (voice) |
 | Kensington Tallman als Riley Andersen (voice) |
 | Diane Lane als Mom (voice) |
 | Kyle MacLachlan als Dad (voice) |
 | Lilimar als Valentina 'Val' Ortiz (voice) |
 | June Squibb als Nostalgia (voice) |
 | Frank Oz als Subconscious Guard Dave (voice) |
 | John Ratzenberger als Fritz (voice) |
 | Flea als Mind Worker Cop Jake (voice) |
 | Yvette Nicole Brown als Coach Roberts (voice) |
 | Sumayyah Nuriddin-Green |
 | Grace Lu |
 | Sarayu Blue |
 | Ron Funches |
 | Dave Goelz als Subconscious Guard Frank (voice) |
 | James Austin Johnson als (voice) |
 | Bobby Moynihan |
 | Paula Pell |
 | Paula Poundstone |
| Kendall Coyne Schofield |
| Kirk R. Thatcher |
 | Yong Yea |
| Meg LeFauve | Writer |
| Kelsey Mann | Director |
| Mark Nielsen | Producer |
| Pete Docter | Executive Producer |
| Natalie Lyon | Casting Director |
| Kevin Reher | Casting Director |
| Jonas Rivera | Executive Producer |
| Dan Scanlon | Executive Producer |
| Dovi Anderson | Animation Supervisor |
| Evan Bonifacio | Animation Supervisor |
| Michael Venturini | Animation Supervisor |
| John Hoffman | Story Supervisor |
| Jason Deamer | Production Design |
| Maurissa Horwitz | Editor |
| Sudeep Rangaswamy | Visual Effects Supervisor |
| Adam Habib | Director of Photography |
| Jonathan Pytko | Director of Photography |
| Andrea Datzman | Original Music Composer |
| Coya Elliott | Supervising Sound Editor |
| Stephen Urata | Sound Re-Recording Mixer |
