 | Kristanna Loken als Rayne |
 | Ben Kingsley als Kagan |
 | Michelle Rodriguez als Katarin |
 | Michael Madsen als Vladimir |
 | Matthew Davis als Sebastian |
 | Will Sanderson als Domastir |
 | Geraldine Chaplin als Fortune Teller |
 | Udo Kier als Regal Monk |
 | Meat Loaf als Leonid |
 | Michael Paré als Iancu |
 | Billy Zane als Elrich |
 | Darren Shahlavi als Priest |
 | Esteban Cueto als Rok |
 | Mădălina Constantin als Amanda |
 | Daniela Nane als Rayne's Mother |
 | T.J. Storm als Strongman / Kagan Vampire Guard #3 |
 | Constantin Bărbulescu als Ringmaster |
| Teona Galgoțiu als Rayne - Age 5 |
 | Răzvan Popa als Bartender |
| Laura Burlarda als Little Girl |
 | Ingrid Bisu als Young Girl |
 | Dicu Aurel als Vampire Male |
| Cristina Iulia Pavalache als Vampire Female |
| Romanița Ionescu als Woman Vampire |
 | Rocky Taylor als Monetary Guard |
| Iulia Popescu als Mother |
| Robert Alexander Baer als Kid (Darius) |
 | Adrienne McQueen als Female Soldier |
| Demeny Gabriel als Kagan's Sentry |
 | Radu Andrei Micu als Sleepy Young Man |
| Bryan C. Knight als Thadius |
| Aden Ambrono als Giant Thrall #1 |
| Florin Roata als Giant Thrall #2 |
 | Mike Dopud als Gregor |
 | Kofi Yiadom als Kagan Vampire Guard #1 |
| Mihai Ionita als Kagan Vampire Guard #1 / Thrall Guard #1 |
| Romeo Raicu als Kagan Vampire Guard #2 |
| Dorin Zaharia als Kagan Vampire Guard #2 / Thrall Guard #2 |
| Petre Dumitru als Kagan Vampire Guard #3 |
| Gabi Serbah als Kagan Vampire Guard #3 / Thrall Guard #3 |
 | Ho-Sung Pak als Kagan Vampire Guard #4 |
| Banica Gheorghe als Kagan Vampire Guard #4 / Thrall Guard #4 |
| Andrabulea Cigel als Kagan Vampire Guard #5 / Thrall Guard #5 |
| Orlando McGuire als Kagan Vampire Guard #6 |
| Alexander Mardan als Kagan Vampire Guard #6 / Thrall Guard #6 |
| Luminita Filimon als Kagan Vampire Guard #7 |
| Vasilescu Valentin als Kagan Vampire Guards #8 |
| Daniel Visan als Thrall Guard #7 |
 | Chris Torres als Brimstone Man (uncredited) |
| Uwe Boll | Director |
| Guinevere Turner | Writer |
| Morris Sutton | Co-Executive Producer |
| Brad Van Arragon | Line Producer |
| Jonathan Shore | Co-Executive Producer |
| Brandon Baker | Associate Producer |
| Uwe Boll | Producer |
| Michael Roesch | Associate Producer |
| James Steuart | Production Design |
| Peter Scheerer | Associate Producer |
| Max Wanko | Associate Producer |
| Sandy Walker | Set Decoration |
| Wolfgang Herold | Executive Producer |
| Jesse Sutton | Co-Executive Producer |
| Cristian Corvin | Art Direction |
| Dan Clarke | Producer |
| Frederic Demey | Associate Producer |
| Henning Lohner | Music |
| Carla Baer | Costume Design |
| Shawn Williamson | Producer |
| Mathias Neumann | Director of Photography |
| Maureen Webb | Casting Director |
| Dan Sales | Associate Producer |
| Connie Parker | Makeup Department Head |
| Vlad Vieru | Art Direction |
| Dorin Zaharia | Stunts |
| Daniel Visan | Stunts |
| Florin Viorel | Stunts |
| Alicia Vela-Bailey | Stunts |
| Mihnea Vargolici | Stunts |
| Vadim Varcolici | Stunts |
| Vasilescu Valentin | Stunts |
| Bogdan Uritescu | Stunts |
| Mihai Ungureanu | Stunts |
| Chris Torres | Stunts |
| Marian Toader | Stunts |
| Daniela Stoica | Stunts |
| Florin Stancu | Stunts |
| Trevori Setru | Stunts |
| Mihai Serban | Stunts |
| Romeo Raicu | Stunts |
| Marian Raicu | Stunts |
| Dumitru Stancu Petre | Stunts |
| Gabriela Petre | Stunts |
| Adrian Pavlovschi | Stunts |
| Cristina Iulia Pavalache | Stunts |
| Telu Paun | Stunts |
| Daniel Pasleaga | Stunts |
| Trevor McWhinney | Stunts |
| Alexander Mardan | Stunts |
| Catalin Mancafa | Stunts |
| Razvan Mamarae | Stunts |
| Alin Luchian | Stunts |
| Viorel Ivanica | Stunts |
| Mihai Ionita | Stunts |
| Banica Gheorghe | Stunts |
| Gabriel Serban | Stunts |
| Marius Florian | Stunts |
| Paul Fister | Stunts |
| Liviu Fister | Stunts |
| Luminita Filimon | Stunts |
| Constantin Dumitru | Stunts |
| Doru Dumitrescu | Stunts |
| Marian Dinca | Stunts |
| Cincan Daniel | Stunts |
| Mihai Danciu | Stunts |
| Doru Constantin | Stunts |
| Andrabulea Cigel | Stunts |
| Ion Carangea | Stunts |
| Nelu Caragea | Stunts |
| Gabi Burlacu | Stunts |
| Aurel Boata | Stunts |
| Florin Barcun | Stunts |
| Einci Aurel | Stunts |
| Dicu Aurel | Stunts |
| Anthony Arcuria | Stunts |
| Vasile Albineț | Stunts |
| David M. Richardson | Editor |
| Chris Kunzmann | Makeup Department Head |
| Olaf Ittenbach | Special Effects Makeup Artist |
| Sascha Kolmikow | Special Effects Makeup Artist |
| Tommy Opatz | Special Effects Makeup Artist |
| Ioana Liță | Key Hair Stylist |
| Clara Tudose | Key Makeup Artist |
| Suzanne Stokes-Munton | Key Hair Stylist |
| Jonathan Shore | Post Production Supervisor |
| Andreea Stanculeanu | Executive In Charge Of Production |
| Irina Chirita | Production Manager |
| Joey Setter | Unit Production Manager |
| Bryan C. Knight | First Assistant Director |
| Jochen Engelke | Sound Re-Recording Mixer |
| Wolfgang Herold | Sound Supervisor |
| Deni King | ADR Supervisor |
| Max Wanko | Sound Designer |
| Max Wanko | Supervising Sound Editor |
| Fritz A. Wollner | Sound Re-Recording Mixer |
| Phil Jones | Visual Effects Supervisor |
| Sven Martin | VFX Supervisor |
| Doug Oddy | VFX Supervisor |
| Rocky Taylor | Stunt Coordinator |
| Marius Ivașcu | Second Unit Director of Photography |
| Marius Ivașcu | Camera Operator |
| Calin Constantin | Gaffer |
| Darren McLean | Gaffer |
| Colleen Bolton | Casting Assistant |
| Paul Klassen | Assistant Editor |
| Wolfgang Herold | Music Supervisor |
| Tracy D. Smith | Script Coordinator |
| Alan Noel Vega | Fight Choreographer |
| Kylie Furneaux | Stunt Double |
| George Stan | Stunts |
