 | Bill Pullman als Dr. Rex Martin |
 | Bill Paxton als Jim Reston |
 | Bud Cort als Jack Halsey |
 | Nicholas Pryor als Man in Bloody White Suit / Ramsen / Ed Conklin |
 | Patricia Charbonneau als Dana Martin |
 | George Kennedy als Vance |
 | Brian Brophy als Ellis |
 | David Sinaiko als Berkovitch |
 | Lee Arenberg als Sacks |
 | Andy Wood als Brain Surgeon |
 | Maud Winchester als Crazy Anna |
 | Lisa Moncure als Board Member |
| Jon Kellam als Board Member |
 | Willie Garson als Board Member |
 | John Paxton als Board Member |
| David Sklare als Board Member |
 | Cynthia Ettinger als Nurse Anderson |
| Shannon Holt als Toni |
 | V.J. Foster als Fred |
 | Brent Hinkley als Dewey |
 | Kyle Gass als Anaesthetist |
 | Deirdre O'Connell als Mrs. Halsey |
| Ann Vincent als Halsey's Aunt |
| Dorothy Vincent als Halsey's Aunt |
| Dean Robinson als Valet |
| Mark Boothby als Neighbor / Eunice Security Guard |
| Steve Ruggles als Restaurant Manager |
| Adam Lima als Bus Boy |
| Jesse Douglas als Canteen Attendant |
 | Patti Tippo als Resident |
 | Barney Burman als Experimental Face |
| Laura McCorkindale als Dancing Madwoman |
| Roscoe Pound als Wrong Man |
| William Simon als Doctor in Lobotomy Film |
 | Alexander von Roon als Self |
| Gene Serdena | Set Decoration |
| Barney Burman | Special Effects Makeup Artist |
| Catherine Harper | Foley Artist |
| Barbara Cohen | Casting |
| Catherine Hardwicke | Production Design |
| Adam Simon | Screenplay |
| Adam Simon | Director |
| Charles Beaumont | Screenplay |
| Peter Rotter | Music |
| Rohn Schmidt | Director of Photography |
| Carol Oblath | Editor |
| Albert T. Dickerson III | Production Manager |
| Julie Corman | Producer |
| Merritt Yohnka | Stunts |
| Gaston Biraben | Dialogue Editor |
| Harri James | Script Supervisor |
| Philippe Browning | Second Unit Director |
| Geraint Bell | Sound Effects Editor |
| Dennis Patterson | Sound Designer |
| Dennis Patterson | Foley Editor |
| Dennis Patterson | ADR Recordist |
| Dennis Patterson | Foley Recordist |
| Patrick J. Statham | Stunt Coordinator |
| Steve Gehrke | Script Supervisor |
| Cynthia Merrill | Foley Artist |
| Gilbert Mercier | Art Direction |
| John Branagan | Stunts |
| Christopher B. Reeves | Dialogue Editor |
| Bill V. Robbins | Production Sound Mixer |
| Mato | Color Timer |
| Camilla Mauritzson Skjaerbaek | Sound Re-Recording Assistant |
| Desne J. Holland | Assistant Hairstylist |
| Desne J. Holland | Assistant Makeup Artist |
| Gregory Kent Simmons | First Assistant Director |
| Angela Moos | Makeup Artist |
| Angela Moos | Hairstylist |
| Paul Di Franco | Music Supervisor |
| Joe Earle | Sound Effects Editor |
| Rob Burman | Special Effects Makeup Artist |
| Craig Felburg | Production Sound Mixer |
| Michael Clark | Sound Effects Editor |
| Thomas Patrick Smith | Second Assistant Director |
| Robyn Jacobs | Special Effects Assistant |
| Leslie Litt | Casting |
| Derrick Kolus | Gaffer |
| Lynn Whitney | Associate Producer |
| Catherine Taieb | Costume Design |
| Benjamin Clark | Second Unit First Assistant Director |
| Michael Soriano | Set Dresser |
| Dimitri Radoyce | Storyboard Artist |
| Robert Perry | Boom Operator |
| Anne Tamrazi | Wardrobe Assistant |
