 | Chrissy Metz als Joyce Smith |
 | Josh Lucas als Brian Smith |
 | Topher Grace als Pastor Jason Noble |
 | Mike Colter als Tommy Shine |
 | Marcel Ruiz als John Smith |
 | Sam Trammell als Dr. Kent Sutterer |
 | Dennis Haysbert als Dr. Garrett |
 | Maddy Martin als Abby Sutterer |
 | Isaac Kragten als Josh |
 | Nikolas Dukic als Reiger |
 | Taylor Mosby als Chayla |
 | Alissa Skovbye als Emma |
 | Chuck Shamata als Fire Chief |
 | Nancy Sorel als Mrs. Abbott |
 | Lisa Durupt als Paula Noble |
 | Rebecca Staab als Cindy Reiger |
 | Travis Bryant als Jonah |
 | Victor Zinck Jr. als Joe Morrow |
 | Kristen Harris als Kay Quinn |
 | Stephanie Czajkowski als Melissa |
 | Connor Peterson als Band Student / Student (uncredited) |
 | Mel Marginet als Trauma Nurse #1 |
 | Logan Creran als Luke Noble |
 | Isla Gorton als Daughter #2 |
 | Kevin P. Gabel als Male Nurse |
 | Karl Thordarson als Don |
| Tristan Mackid als Punk |
| Phil Hepner als Mr. Reiger |
| Jemma Griffith als Doreen |
| Kerry Grace Tait als Joyce's friend #1 |
 | Elena Anciro als Trauma Nurse #2 |
| Danielle Savage als Mom #2 |
 | Saul Elias als 7 Year Old John |
 | Lois Brothers als ER Nurse |
| Roxann Dawson | Director |
| Grant Nieporte | Writer |
| Maysie Hoy | Editor |
| Zoran Popovic | Director of Photography |
| DeVon Franklin | Producer |
| Laura Anania | Costumer |
| Gae S. Buckley | Production Design |
| James Steuart | Art Direction |
| Stephen Arndt | Set Decoration |
| Kimberly Adams | Costume Design |
| Becki Cross Trujillo | Executive Producer |
| Stephen Curry | Executive Producer |
| Jessica Dunn | Co-Producer |
| Samuel Rodriguez | Executive Producer |
| Justine Hempe | Casting |
| Sheila Jaffe | Casting |
| Marcelo Zarvos | Original Music Composer |
| Joyce Smith | Book |
| Doug Morrow | Special Effects Makeup Artist |
| Margarita Vailas | Makeup Artist |
| Kristen Watts | Makeup Artist |
| David Betancourt | ADR Mixer |
| Russ Dyck | Sound Recordist |
| Marc Glassman | Sound Effects Editor |
| Tim Gomillion | Sound Recordist |
| Mike Horton | Foley Artist |
| Paul Lynch | ADR Recordist |
| Paul Massey | Sound Re-Recording Mixer |
| Tim McKeown | Foley Artist |
| Charleen Richards-Steeves | ADR Mixer |
| Derek Vanderhorst | Sound Re-Recording Mixer |
| Chuck Robinson | Stunt Coordinator |
| Dan Shea | Stunt Coordinator |
| Andrea von Foerster | Music Supervisor |
| Shamess Shute | First Assistant Director |
| Joan Kelley Bierman | Post Production Supervisor |
| Devin Marshall | Stunt Double |
| Aj Risi | Stunt Double |
| BJ Verot | Stunts |
| Jonny Caines | Stunt Double |
| Robert Borges | Stunts |
| Nancy J. Lilley | Stunt Double |
| Kelly Wolfman | Script Supervisor |
| Cathie J. Edgar | Location Manager |
| Steven Ackerman | Still Photographer |
| Becki Cross Trujillo | Unit Production Manager |
| Nicole Shizuka Oguchi | Production Manager |
| Gurjit Chohan | Second Assistant Director |
| Puneet Chawla | Second Assistant Director |
| Jim Steuart | Supervising Art Director |
| Donna Jenkyns | Art Department Coordinator |
| Brent Bell | Set Designer |
| Robert Kestler | Assistant Set Decoration |
| Owen Bird | Lead Set Dresser |
| Robert K. Laurie | Set Dresser |
| Greg Warkentin | Set Dresser |
| Robb Paraskevopoulos | Set Dresser |
| Heather Arabsky | Set Dresser |
| Kathryn Slessor | Set Dresser |
| Michael Mogatas | Set Dresser |
| Katie Man | Art Department Assistant |
| Benjamin Cairns | Second Assistant Director |
| Cara Denyer | Third Assistant Director |
| Marcus James | Camera Operator |
| Russel Bowie | First Assistant "A" Camera |
| Steven K. Johnson | Second Assistant "A" Camera |
| Junichi Hosoi | "B" Camera Operator |
| Junichi Hosoi | Steadicam Operator |
| Jason Heke | First Assistant "B" Camera |
| Izak Mallin | Second Assistant "B" Camera |
| Shauna Towley | "C" Camera Operator |
| Braden Haggerty | Underwater Camera |
| Allen Fraser | Still Photographer |
| Sacha Rosen | Boom Operator |
| Anita Lubosch | Boom Operator |
| Lee Grubin | First Assistant Editor |
| Derek Vanderhorst | Supervising Sound Editor |
| Warren Hendriks | Supervising Sound Editor |
| Alexandra Andrus | Assistant Editor |
| Kurt Leitner | Post Production Coordinator |
| Michael T. Marlett | Visual Effects Editor |
| Laurence Mardon | Gaffer |
| Blaine Komatich | Best Boy Electric |
| Marvin Klein | Generator Operator |
| Sam Osland | Rigging Gaffer |
| Stephen Madden | Key Grip |
| Mingan Nabess | Best Boy Grip |
| Robert R. Thomson | Dolly Grip |
| Craig Leatherdale | Dolly Grip |
| Derek Hedley | Grip |
| Devyne Johnson | Assistant Costume Designer |
| Joulles Wright | Costume Supervisor |
| Rosa J. Colón | Costume Set Supervisor |
| Deneen McArthur | Set Costumer |
| Joy Willis | Seamstress |
| Nicole Pearson | Truck Supervisor |
| Doug Morrow | Makeup Department Head |
| Kristy Greig | First Assistant Makeup Artist |
| Kendall Lewis | Makeup Trainee |
| Stacey Mendoza | Key Hair Stylist |
| Travis Marszalek | First Assistant Hairstylist |
| Cliff Sumter | Assistant Location Manager |
| G. Thomas Arnold | Assistant Location Manager |
| Jim Heaton | Assistant Location Manager |
| Mike Black | Location Assistant |
| Luke Annand | Location Assistant |
| Alexis Labra | Property Master |
| Aaron W.R. Johnston | Assistant Property Master |
| Tony Kenny | Special Effects Coordinator |
| Hudson Kenny | Special Effects Supervisor |
| Olaf Dux | Construction Coordinator |
| Katharina Stieffenhofer | Greensman |
| Aaron Graham | Production Coordinator |
| Casandra Brescacin | Assistant Production Coordinator |
| Renata Wasylkewycz | Transportation Coordinator |
| Pia Athayde | Production Accountant |
| Garth Yakymyk | First Assistant Accountant |
| Jean Du Toit | Assistant Accountant |
| Marilyn McEachern | Assistant Accountant |
| Tami Bailey | Payroll Accountant |
| Paula Holt | Post Production Accountant |
| Stephanie Gorin | Casting |
| Jim Heber | Casting |
| Jackie Lind | Casting |
| Alexis Winter | Casting Associate |
| Tamara Gorski | Casting Associate |
| Lori Stefaniuk | Extras Casting |
| Patricia Kress | Extras Casting Assistant |
| John Mysyk | Transportation Coordinator |
| RoseAnna Schick | Unit Publicist |
| Ti Hallas | Studio Teacher |
| Terri Cherniack | Studio Teacher |
| Mike Currie | Craft Service |
| Flo Krisko | Animal Coordinator |
| Chris Ritvo | Visual Effects Supervisor |
| Warren Hendriks | Sound Designer |
| Jacob Houchen | ADR Supervisor |
| Helen Lutrell | Dialogue Editor |
| Smokey Cloud | Assistant Sound Editor |
| Walter Spencer | Foley Supervisor |
| David Lucarelli | ADR Recordist |
| Christine Sirois | ADR Recordist |
| Derek Casari | ADR Engineer |
| Johnny Gidcomb | ADR Voice Casting |
| Stephanie Lowry | Music Editor |
| Michael K. Bauer | Music Editor |
