 | Bill Murray als Don Johnston |
 | Sharon Stone als Laura |
 | Jessica Lange als Carmen |
 | Tilda Swinton als Penny |
 | Frances Conroy als Dora |
 | Alexis Dziena als Lolita |
 | Chloë Sevigny als Carmen's Assistant |
 | Christopher McDonald als Ron |
 | Julie Delpy als Sherry |
 | Jeffrey Wright als Winston |
 | Heather Simms als Mona |
 | Chris Bauer als Dan |
 | Larry Fessenden als Will |
 | Brea Frazier als Rita |
| Jarry Fall als Winston and Mona's Kid |
| Korka Fall als Winston and Mona's Kid |
| Saul Holland als Winston and Mona's Kid |
| Zakira Holland als Winston and Mona's Kid |
| Niles Lee Wilson als Winston and Mona's Kid |
 | Meredith Patterson als Flight Attendant |
 | Jennifer Rapp als Girl on Bus |
| Nicole Abisinio als Girl on Bus |
 | Ryan Donowho als Young Man on Bus |
 | Dared Wright als Rabbit Owner |
 | Suzanne Hevner als Mrs. Dorston |
| Brain McPeck als Guy in S.U.V. |
| Matthew McAuley als Guy in S.U.V. |
 | Pell James als Sun Green |
 | Mark Webber als The Kid |
| Homer Murray als Kid in Car |
| Rachel Puchkoff als Girl in House (uncredited) (unconfirmed) |
| Jim Jarmusch | Director |
| Frederick Elmes | Director of Photography |
| Jay Rabinowitz | Editor |
| Ellen Lewis | Casting |
| Mark Friedberg | Production Design |
| Sarah Frank | Art Direction |
| Lydia Marks | Set Decoration |
| Jon Kilik | Producer |
| Stacey Smith | Producer |
| Mulatu Astatke | Original Music Composer |
| Siri Hustvedt | Thanks |
| David Wahnon | Sound Editor |
| Coll Anderson | Sound Effects Editor |
| Robert Hein | Supervising Sound Editor |
| Drew Kunin | Sound Mixer |
| Glenfield Payne | Sound Effects Editor |
| Dominick Tavella | Sound Re-Recording Mixer |
| Bill Raden | Idea |
| Jim Jarmusch | Writer |
| Sara Driver | Idea |
| Ann Ruark | Co-Producer |
| Karen L. Thorson | Associate Producer |
| John Dunn | Costume Design |
| Milton Buras | Hairstylist |
| Judy Chin | Key Makeup Artist |
| Frances Hannon | Hairstylist |
| Frances Hannon | Makeup Artist |
| Mandy Lyons | Hair Department Head |
| Gwen Bialic | Production Supervisor |
| Ann Ruark | Unit Production Manager |
| Karen L. Thorson | Post Production Supervisor |
| Sarah Rae Garrett | Second Second Assistant Director |
| Todd Pfeiffer | First Assistant Director |
| Shea Rowan | Second Assistant Director |
| Stephen Barth | Scenic Artist |
| Peter Bundrick | Head Carpenter |
| Dominick Cocuzzo | Construction Grip |
| Ralph Contrado | Scenic Artist |
| Alex DiGerlando | Art Department Coordinator |
| Stephen Finkin | On Set Dresser |
| Tanis Gray | Art Department Assistant |
| Sandy Hamilton | Property Master |
| Richard Hebrank | Construction Coordinator |
| Arlo Hoffman | Set Dresser |
| T.W. John House | Construction Grip |
| Robert Keller | Carpenter |
| Lisa Kennedy | Scenic Artist |
| Jonathan Kim | Set Dresser |
| Rob Landoll | Scenic Artist |
| Elizabeth Linn | Charge Scenic Artist |
| John Peter Melendez | Set Dresser |
| Michael G. Miller | Construction Grip |
| Kris Moran | Assistant Property Master |
| Mark Pollard | Graphic Designer |
| Heather Prendergast | Assistant Set Decoration |
| Will Scheck | Leadman |
| Mark Paul Selemon | Set Dresser |
| Jonathan Tessler | Props |
| Don Zappia | Construction Grip |
| Tomas Zeman | Art Department Trainee |
| Ryan Collison | Foley Recordist |
| Mark Goodermote | Boom Operator |
| Terrance Laudermilch | Sound Re-Recording Mixer |
| Tommy Louie | Utility Sound |
| Jan McLaughlin | Utility Sound |
| Sylvia Menno | Dialogue Editor |
| Jay Peck | Foley Artist |
| Kira Smith | Utility Sound |
| Marilyn Teorey | Foley Editor |
| Phillip Fuller | Sound Mix Technician |
| J. John Corbett | Visual Effects |
| Mark Tureski | Digital Film Recording |
| Keith Yurevitz | Visual Effects |
| Jan Cilliers | Digital Compositor |
| Chris M. Halstead | Digital Compositor |
| Manny Siverio | Stunt Coordinator |
| Bill Almeida | Rigging Gaffer |
| Robert M. Andres | Key Grip |
| Liza Bambenek | Camera Loader |
| Alison Barton | Grip |
| Angela Bellisio | Second Assistant Camera |
| Tony Campenni | Dolly Grip |
| Ben D'Andrea | Grip |
| Samuel G. Friedman | Best Boy Electric |
| Jamie Gallagher | Genetator Operator |
| Carlos Omar Guerra | First Assistant Camera |
| Sandy Hays | Camera Operator |
| Sandy Hays | Steadicam Operator |
| David Lee | Still Photographer |
| Jonathan Lumley | Gaffer |
| John Panuccio | Rigging Grip |
| Robert T. Prate | Additional Grip |
| Lee Shevett | Additional Grip |
| Chris Skutch | Best Boy Grip |
| Phil Testa | Base Camp Operator |
| Jennifer Euston | Casting Associate |
| Meghan Rafferty | Casting Assistant |
| Grant Wilfley | Extras Casting |
| Stephanie Biear | Seamstress |
| David Davenport | Wardrobe Supervisor |
| Amy Habacker | Costumer |
| Susan J. Wright | Key Costumer |
| Debbie Lucas | Seamstress |
| Jennifer Apel | First Assistant Editor |
| Jason Crump | Colorist |
| Matt Mayer | First Assistant Editor |
| Perri Pivovar | First Assistant Editor |
| Cathy Rait | Color Timer |
| Stan Sztaba | Negative Cutter |
| Payton Dunham | Location Scout |
| Michael Hartel | Assistant Location Manager |
| Kellie Morrison | Location Manager |
| Justin Rosini | Location Assistant |
| Jared A. Smith | Location Scout |
| Yorgo Stathopoulos | Location Assistant |
| Mark Van Holstein | Location Scout |
| David Velasco | Location Scout |
| Jay Rabinowitz | Music Editor |
| Sara Driver | Script Consultant |
| John T. Maye | Assistant Script |
| Julie Oppenheimer | Script Supervisor |
| Frank Appedu | Driver |
| William Baker | Driver |
| Joe Blessington | Driver |
| John Canavan | Driver |
| Thomas Crehan | Driver |
| James Giblin | Driver |
| Paul Kane | Driver |
| Jim Kelly | Driver |
| Robert Lapine | Driver |
| Jimmy Mahr | Driver |
| Gene O'Neill | Transportation Captain |
| Joshua Priestley | Picture Car Coordinator |
| John Queenie | Driver |
| J.R. Scarlatos | Driver |
| Tara Anderson | Intern |
| Randall Balsmeyer | Title Designer |
| Daniela Barbosa | Set Production Assistant |
| Megha Barnabas | Intern |
| Brette Billow | Intern |
| Anna Bosco | Post Production Accountant |
| Jason Boshart | Set Production Assistant |
| Costanza Theodoli Braschi | Art Department Assistant |
| Liliana Candelario | Intern |
| Iawann Carmona | Intern |
| Anne Carson | Production Assistant |
| J. John Corbett | Title Designer |
| Stephen Delpino | Assistant Chef |
| Rachel Dengiz | Associate Producer |
| Shaun Duffy | Set Production Assistant |
| Lance Edmands | Intern |
| John B. Finn | Post Production Accountant |
| Scott Franklin | Intern |
| Shellie Gillespie | Payroll Accountant |
| Greg Gilman | Set Production Assistant |
| Flax Glor | Publicist |
| Amber Gristak | Stand In |
| Nathan Grubb | Craft Service |
| Tina Hartel | Stand In |
| Sean Hogan | Production Accountant |
| Steven Holtzman | Production Assistant |
| Joshua Huffman | Production Office Assistant |
| Debi Karolewski | Actor's Assistant |
| Eric Kench | Intern |
| Ilana Lifshitz | Assistant Production Coordinator |
| Adriana Machado | Intern |
| Matthew Mason | Set Production Assistant |
| Carl McKinney | Projection |
| Michael McNamara | Intern |
| Jeremy Mohler | Set Production Assistant |
| Tony Muro | Publicist |
| Frank Murray | Assistant Accountant |
| George Nannas | Chef |
| Steve Oppenheim | Set Production Assistant |
| Tony Osso | Production Coordinator |
| John Reeves | Craft Service |
| Jessica Replansky | Production Secretary |
| Andrea Roa | Production Office Assistant |
| Jonathan Russek | Production Assistant |
| Christina Schaich | Production Office Assistant |
| José Tejada | Security Coordinator |
| Rob van de Laar | Production Assistant |
| Danny Velez | Intern |
| Katrina Whalen | Intern |
| Dared Wright | Stand In |
| Andrew Yakovlev | Intern |
