 | Richard Gere als Off. Eddie Dugan |
 | Don Cheadle als Det. Clarence 'Tango' Butler |
 | Ethan Hawke als Det. Sal Procida |
 | Wesley Snipes als Casanova 'Caz' Phillips |
 | Vincent D'Onofrio als Bobby 'Carlo' Powers |
 | Ellen Barkin als Agent Smith |
 | Michael Kenneth Williams als Red |
 | Shannon Kane als Chantel |
 | Brían F. O'Byrne als Det. Ronny Rosario |
 | Will Patton als Lt. Bill Hobarts |
 | Lili Taylor als Angela Procida |
 | Wass Stevens als Det. Patrick Leary |
 | Armando Riesco als Det. George Montress |
 | Wade Allain-Marcus als C-Rayz |
 | Logan Marshall-Green als Melvin Panton |
 | Jesse Williams als E. Quinlan |
 | Hassan Johnson als Beamer |
 | Jas Anderson als K. Rock |
 | John D'Leo als Vinny |
 | Stella Maeve als Cynthia |
 | Raquel Castro als Katherine |
 | Robert John Burke als State Trooper #1 |
 | Cle Sloan |
 | Bruce MacVittie als Father Scarpitta (as Bruce Macvittie) |
 | Sarah Thompson als Sarie |
 | Thomas Jefferson Byrd als Uncle Jeb |
 | Lela Rochon als Investigator #1 (as Lela Rochon Fuqua) |
 | Ed Moran als Investigator #2 |
 | Isiah Whitlock Jr. als Investigator #3 (as Isiah Whitlock) |
 | Tawny Cypress als Allisa |
| Danny Dimbort | Executive Producer |
| Mary Viola | Executive Producer |
| Avi Lerner | Executive Producer |
| Michael C. Martin | Writer |
| Robert Greenhut | Executive Producer |
| Basil Iwanyk | Producer |
| Kat Samick | Producer |
| Suzanne Smith Crowley | Casting |
| Jesse Kennedy | Executive Producer |
| Antoine Fuqua | Director |
| Boaz Davidson | Executive Producer |
| Jeanne O'Brien-Ebiri | Producer |
| Patrick Murguia | Director of Photography |
| John Langley | Producer |
| Marcelo Zarvos | Original Music Composer |
| Elie Cohn | Producer |
| Antoine Fuqua | Executive Producer |
| Trevor Short | Executive Producer |
| Barbara Tulliver | Editor |
| Juliet Polcsa | Costume Design |
| John Thompson | Producer |
| Marco Weber | Executive Producer |
| Mary Vernieu | Casting |
| Thérèse DePrez | Production Design |
| Mila Khalevich | Set Decoration |
| Matiki Anoff | Makeup Department Head |
| Maurice Schell | Sound Designer |
| John Cenatiempo | Stunt Coordinator |
| Richard Hebrank | Construction Coordinator |
| Mariusz Glabinski | Sound Effects Editor |
| Mike O'Shea Jr. | Camera Operator |
| Patrick Murguia | Camera Operator |
| Nancy Allen | Music Editor |
| Eric J. Paul | Music Editor |
| John M. Davis | Music Editor |
| Ed Duranté | Script Supervisor |
| Mike O'Shea Jr. | Steadicam Operator |
| Roderick Alleyne | Production Supervisor |
| Tom Fleischman | Sound Re-Recording Mixer |
| Glenn Allen | Visual Effects Producer |
| Richard Friedlander | Visual Effects Producer |
| Phillip V. Caruso | Still Photographer |
| Alan J. Lawson | Scenic Artist |
| Shawnique Hill | Set Costumer |
| Jennifer Dunnington | Music Editor |
| Lauren Buckley | Art Department Coordinator |
| Peter Bundrick | Construction Foreman |
| Phillip Schneider | Scenic Artist |
| Patricia Sprott | Scenic Artist |
| Jay Fortune | Gaffer |
| Justin Ball | Visual Effects Supervisor |
| Nicholas Bernstein | Location Manager |
| Peter DeCurtis | Leadman |
| Maurice Schell | Supervising Sound Editor |
| Debbe DuPerrieu | Set Costumer |
| Deirdre Horgan | Script Supervisor |
| Peter Baran | Art Direction |
| Dan Evans Farkas | Music Editor |
| Richard King | Sound Effects Editor |
| Connie Brink | Special Effects Coordinator |
| Lindsay Graham Ahanonu | Casting Associate |
| Thomas Dolan | Rigging Gaffer |
| Ralph Rea | Rigging Grip |
| Brian McClean | Best Boy Electric |
| Jessica Kelly | Casting Associate |
| Ruth Hernandez | ADR Editor |
| Bret Johnson | Sound Recordist |
| Laura Civiello | Dialogue Editor |
| Erica Kissack | Contact Lens Technician |
| Nathan J. Busch II | Hair Department Head |
| Lyndell Quiyou | Hairstylist |
| Carmen S. Riviera | Key Hair Stylist |
| Sunday Englis | Key Makeup Artist |
| LuAnn Claps | Makeup Artist |
| Kentaro Yano | Tattooist |
| Joe Napolitano | First Assistant Director |
| Joe Napolitano | Producer |
| Peter Soldo | Second Assistant Director |
| Angela Jensen | Second Second Assistant Director |
| Lorraine Z. Calvert | Assistant Costume Designer |
| Lauren Press | Assistant Costume Designer |
| Alex Bovaird | Costume Coordinator |
| Tommy Boyer | Costumer |
| Aissatou Parks | Set Costumer |
| Barrett Hong | Wardrobe Supervisor |
| Gus Magalios | Best Boy Grip |
| Kevin Kasarda | Camera Loader |
| Louis Sabat | Dolly Grip |
| Mike Yurich | Dolly Grip |
| Kenneth Potter | Electrician |
| Jim McCullough Jr. | Electrician |
| Bobby Mancuso | First Assistant "A" Camera |
| Scott Tinsley | First Assistant "B" Camera |
| Raymond Fortune | Generator Operator |
| Kevin Califano | Grip |
| Kevin Gilligan | Grip |
| Rocco Proscia | Grip |
| Ernest Yurich | Grip |
| George Patsos | Key Grip |
| Billy Patsos | Key Rigging Grip |
| James J. McCullagh | Lighting Technician |
| Jason Brignola | Second Assistant "A" Camera |
| Julian J. Delacruz | Second Assistant "B" Camera |
| Adam Johnson | Second Assistant "B" Camera |
| Hunter Popalis | Art Department Production Assistant |
| John Galuppo | Construction Grip |
| Derrick Kardos | Graphic Designer |
| Michael Saccio | Property Master |
| Eddie DeCurtis | Set Dresser |
| Frank DeCurtis | Set Dresser |
| Bear Davies | Set Dresser |
| Michael Leather | Set Dresser |
| John Saracco | Set Dresser |
| David Boulton | ADR Mixer |
| Brian Gallagher | ADR Recordist |
| Alfredo Viteri | Boom Operator |
| Eric McAllister | First Assistant Sound Editor |
| Igor Nikolic | First Assistant Sound Editor |
| Jay Peck | Foley Artist |
| Matthew Haasch | Foley Editor |
| Ryan Collison | Foley Mixer |
| John Werner | Foley Supervisor |
| Gerald Donlan | Sound Editor |
| Joe White | Sound Mixer |
| Joshua Anderson | Utility Sound |
| John Scott Cook | Associate Editor |
| Ryan Bennett | Colorist |
| Stefan Sonnenfeld | Colorist |
| Sean Dunckley | Colorist |
| Rob Cadzow | Digital Intermediate |
| Nicholas Hasson | Digital Intermediate Editor |
| Devin Sterling | Digital Intermediate Producer |
| Luke Ciarrocchi | Editorial Production Assistant |
| Yale Kozinski | First Assistant Editor |
| Selena Arizanovic | Music Coordinator |
| John Houlihan | Music Supervisor |
| Andy Goldman | Title Designer |
| Al Cerullo | Pilot |
| Ryder Washburn | Armorer |
| Kathi Scharer | Production Accountant |
| Tom Antonetti | Police Consultant |
| Paul Lozada | Police Consultant |
| Tom Murray | Police Consultant |
| Joseph Bannon | Police Consultant |
| Jerry Speziale | Police Consultant |
| Ahsaan Mitchell | Production Assistant |
| Alan J. Lam | Production Controller |
| Peter I. Sabat | Production Coordinator |
| Kenneth Daniels | Production Secretary |
| Kirstin Liu | Production Secretary |
| Scott 'Hitman' Sims | Production Secretary |
| Cle Sloan | Production Secretary |
| Theron Alford | Set Production Assistant |
| Cynthia Bauer | Set Production Assistant |
| Ja'nae Burgess | Set Production Assistant |
| Lisa Falzarano | Set Production Assistant |
| Garrette Henson | Set Production Assistant |
| Steve Jean-Baptiste | Set Production Assistant |
| Jon Shaw | Set Production Assistant |
| Aaron Vexler | Stunts |
