 | Owen Wilson als Lightning McQueen (voice) |
 | Larry the Cable Guy als Mater (voice) |
 | Michael Caine als Finn McMissile (voice) |
 | Emily Mortimer als Holley Shiftwell (voice) |
 | John Turturro als Francesco Bernoulli (voice) |
 | Eddie Izzard als Sir Miles Axlerod (voice) |
 | Thomas Kretschmann als Professor Z (voice) |
 | Guido Quaroni als Guido (voice) |
 | Joe Mantegna als Grem (voice) |
 | Peter Jacobson als Acer (voice) |
 | Bruce Campbell als Rod "Torque" Redline (voice) |
 | Tony Shalhoub als Luigi (voice) |
 | Darrell Waltrip als Darrell Cartrip (voice) |
| Brent Musburger als Brent Mustangburger (voice) |
 | Jason Isaacs als Siddeley / Leland Turbo (voice) |
| David Hobbs als David Hobbscap (voice) |
 | Stanley Townsend als Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice) |
 | Lloyd Sherr als Fillmore / Combat Ship (voice) |
 | Paul Dooley als Sarge (voice) |
| Michel Michelis als Tomber (voice) |
 | Sig Hansen als Crabby (voice) |
 | Franco Nero als Uncle Topolino (voice) |
 | Vanessa Redgrave als The Queen / Mama Topolino (voice) |
 | Bonnie Hunt als Sally Carrera (voice) |
 | Cheech Marin als Ramone (voice) |
 | Jenifer Lewis als Flo (voice) |
 | Michael Wallis als Sheriff (voice) |
 | Katherine Helmond als Lizzie (voice) |
 | John Ratzenberger als Mack (voice) |
 | Jeff Garlin als Otis (voice) |
| Patrick Walker als Mel Dorado (voice) |
 | Lewis Hamilton als Lewis Hamilton (voice) |
 | Velibor Topic als Alexander Hugo (voice) |
| John Mainieri als J. Curby Gremlin (voice) |
 | Brad Lewis als Tubbs Pacer (voice) |
 | Richard Kind als Van (voice) |
 | Edie McClurg als Minny (voice) |
 | Teresa Gallagher als Mater's Computer (voice) |
 | Jeff Gordon als Jeff Gorvette (voice) |
 | John Lasseter als Additional Voices (voice) |
| Mark Winterbottom als Frosty (voice) |
 | Daisuke Tsutsumi als Additional Voices (voice) |
 | Fernando Alonso als Fernando Alonso (voice) |
| Vitaly Petrov als Vitaly Petrov (voice) |
| Jan Nilsson als Flash (voice) |
| Memo Rojas als Memo Rojas (voice) |
 | Jacques Villeneuve als Jacques Villeneuve (voice) |
 | Sebastian Vettel als Sebastian Vettel (voice) |
| Catherine Bolt als Additional Voices (voice) |
| Jess Fulton als Additional Voices (voice) |
| Sonoko Konishi als Additional Voices (voice) |
 | Gillian Bolt als Additional Voices (voice) |
| John Lasseter | Director |
| John Lasseter | Original Story |
| Gary Rydstrom | Thanks |
| Darla K. Anderson | Thanks |
| Harley Jessup | Production Design |
| Sophie Vincelette | Lead Set Dresser |
| Nathan Stanton | Script Supervisor |
| Nathaniel McLaughlin | Art Direction |
| Jerome Ranft | Sculptor |
| Jeremy Lasky | Director of Photography |
| Ellen Moon Lee | Graphic Designer |
| Shawn Krause | Supervising Animator |
| Brett Coderre | Animation |
| Doug Dooley | Animation |
| Wendell Lee | Animation |
| Daniel Mason | Animation |
| Victor Navone | Animation Director |
| Andrew L. Schmidt | Animation |
| Dave Mullins | Supervising Animator |
| Katherine Ringgold | Second Film Editor |
| Mark Nielsen | Associate Producer |
| Tricia Andres | Thanks |
| Paul Cichocki | Post Production Supervisor |
| Michael Silvers | Supervising Sound Editor |
| Dennie Thorpe | Foley Artist |
| Jana Vance | Foley Artist |
| Steve Jobs | Thanks |
| Sharon Calahan | Director of Photography |
| Dan Fogelman | Original Story |
| Teresa Eckton | Sound Effects Editor |
| Tom Myers | Sound Designer |
| Michael Giacchino | Original Music Composer |
| Stephen M. Davis | Music Editor |
| Brad Lewis | Original Story |
| Brad Lewis | Co-Director |
| Ira Hearshen | Orchestrator |
| Tim Simonec | Conductor |
| Brendan Donnison | ADR Voice Casting |
| Kevin Reher | Casting |
| Andrew Jimenez | VFX Artist |
| Stephen Schaffer | Editor |
| Dan Wallin | Scoring Mixer |
| Josh Cooley | Storyboard Artist |
| Josh Cooley | Additional Script Supervisor |
| Ronald G. Roumas | Sound Recordist |
| Ben Queen | Screenplay |
| Alexander Woo | Storyboard Artist |
| Derek Thompson | Storyboard Artist |
| Connor Funk | Thanks |
| Chris Montan | Executive Music Producer |
| Bob Scott | Animation |
| Natalie Lyon | Casting |
| Denise Ream | Producer |
| Jay Shuster | Art Direction |
| George Doering | Musician |
| Cameron Patrick | Orchestrator |
| Cameron Patrick | Musician |
| Scott Morse | Storyboard Artist |
| Erik Benson | Storyboard Artist |
| Kevin O'Brien | Storyboard Artist |
| Kyle Ranson-Walsh | Story Manager |
| Tom MacDougall | Music Supervisor |
| David Pringle | Sound Editor |
| Carlo Vogele | Animation |
| Sean England | Foley Recordist |
| Michael Semanick | Sound Re-Recording Mixer |
| David C. Hughes | Sound Effects Editor |
| Chris Wiggum | Publicist |
| Pascal Garneau | Foley Supervisor |
| Simon Allen | Animation |
| Al Nelson | Sound Effects Editor |
| Kevin Rose-Williams | First Assistant Editor |
| Jim McKee | Sound Re-Recording Mixer |
| Brian Fee | Storyboard Artist |
| Nick Sung | Storyboard |
| Mark Dinicola | Colorist |
| Susan Bradley | Title Designer |
| Peter Boyer | Orchestrator |
| Norman Ludwin | Musician |
| Justin Pearson | Music Editor |
| Royce Wesley | Animation |
| Daniel Chong | Storyboard Artist |
| Erick Oh | Fix Animator |
| Bert Berry | Art Direction |
| Brad Dechter | Orchestrator |
| Frank Clary | Assistant Sound Designer |
| Steve Slanec | ADR Editor |
| Andrea Datzman | Orchestrator |
| Andrea Datzman | Music Coordinator |
| Ramiro Lopez Dau | Animation |
| Cassandra Barbour | Thanks |
| Ryan Kautzman | Software Engineer |
| Apurva Shah | Supervising Technical Director |
| Jake Martin | Production Manager |
| Sajan Skaria | Characters |
| Robert Moyer | Characters |
| Victoria R. Manley | Script Supervisor |
| Colin Bohrer | Editorial Manager |
| Serena Warner | Additional Editing |
| Shannon Ryan | Animation Manager |
| Michal Makarewicz | Animation Director |
| Lucy Laliberte | Animation Fix Coordinator |
| Simon Diggins | ADR Recordist |
| Vladimir Kooperman | Animation |
| Christina Garcia Weiland | Set Dressing Artist |
| Andrew Coats | Animation |
| Bill Watral | VFX Artist |
| Aaron Hartline | Animation |
| Robb Denovan | Animation |
| Luigi Passalacqua | Craft Service |
| Sungyeon Joh | Master Lighting Artist |
| Joshua Hollander | 3D Director |
| James Thatcher | Musician |
| Doug Sheppeck | Animation |
| Kevin Chesnos | Animation |
| Don Crum | Animation |
| Steve Mason | Animation |
| Jean-Claude Tran | Animation |
| Austin Madison | Animation |
| Fatima Mojaddidy | Systems Administrators & Support |
| Jason Johnston | VFX Artist |
| Susan Frank | Production Coordinator |
| Corey Tyler | Foley Recordist |
| Amit Baadkar | Visual Effects Technical Director |
| Eric Froemling | VFX Artist |
| Dave Hale | VFX Artist |
| Jim Cody Harrington | Visual Effects Technical Director |
| Laurie Kim | Software Engineer |
| Konstantin Promokhov | Visual Effects Technical Director |
| Eric Andraos | Set Dressing Artist |
| Lindsay Andrus | Animation |
| Jeremy Birn | Lighting Artist |
| Jude Brownbill | Animation |
| Airton Dittz Jr. | Master Lighting Artist |
| Craig Foster | Title Designer |
| Craig Foster | Graphic Designer |
| Neil Helm | Animation |
| Katherine Ipjian | Lighting Artist |
| Mitch Kopelman | Master Lighting Artist |
| Aaron Koressel | Animation |
| Bruce Kuei | Animation |
| Holger Leihe | Animation |
| Javier Moya Alonso | Animation |
| Allison W. Nelson | Production Coordinator |
| Jayson Price | Animation |
| Andreas Procopiou | Animation |
| Jordan Rempel | Master Lighting Artist |
| Eric Rosales | Production Coordinator |
| Michael Sauls | Fix Animator |
| Julien Schreyer | Master Lighting Artist |
| Brett Schulz | Animation |
| Stefan Schumacher | Fix Animator |
| David Shavers | Master Lighting Artist |
| Matthew Strangio | Animation |
| Raphael Suter | Animation |
| Ricky Wight | Fix Animator |
| Anthony Ho Wong | Animation |
| Andrew Page | Music Director |
| Hayley Iben | Software Engineer |
| Dirk Van Gelder | Software Team Lead |
| Tamsen Mitchell | Project Manager |
| Briana Gardner | Publicist |
| Terry Lee Moseley | Systems Administrators & Support |
| Peter Plackowski | Systems Administrators & Support |
| Ian Westcott | Systems Administrators & Support |
| Brian Boyd | Master Lighting Artist |
| Steven James | Lighting Artist |
| Ken Lao | Master Lighting Artist |
| Jason Hudak | Associate Editor |
| Chris King | VFX Artist |
| Andy Thomas | Systems Administrators & Support |
| Andy Witkin | In Memory Of |
| Karl Vincent | Musician |
| Mark LeVang | Musician |
| Jeff Bunnell | Musician |
| Mark Gasbarro | Orchestrator |
| Anna Noakes | Musician |
| Courtney Casper Kent | Animation Coordinator |
| Jae Hyung Kim | Animation |
| Benjamin Su | Animation |
| Becky Neiman | Art Department Manager |
| Gary Bruins | Visual Effects Supervisor |
| Piper Freeman | Production Coordinator |
| Andy Lin | Lighting Artist |
| Erick Ziegler | Post Production Coordinator |
| Michael Rutter | Set Dressing Artist |
| Mike Sundy | Systems Administrators & Support |
| Shawn Hovis | Systems Administrators & Support |
| Charu Clark | Lighting Artist |
| Tim Evatt | Set Designer |
| Catherine Hang-Hicks | Animation |
| Max Sachar | Animation Coordinator |
| Farhez Rayani | Lighting Artist |
| Afonso Salcedo | Lighting Artist |
| Adam Burke | Animation |
| Ken Kim | Animation |
| Rob Duquette Thompson | Animation |
| Stephen L. Wong | Animation |
| Chiwook Han | Fix Animator |
| Katelin C. Holloway | Story Coordinator |
| Jason Kim | Software Engineer |
| Ross Dickinson | Systems Administrators & Support |
| Marty Lew | Systems Administrators & Support |
| Auburn C. 'Aubie' Schmidt | Systems Administrators & Support |
| Curran W. Giddens | Animation |
| Rich McKain | Animation |
| Kristoff Vergne | Animation |
| Michelle Ohana | Animation |
| Jose Rosa | Post Production Assistant |
| Malcolm Blanchard | Software Engineer |
| Alden Chew | Software Engineer |
| Mark Hessler | Software Engineer |
| Shiqi Yang | Software Engineer |
| Catherine Obuhoff | Systems Administrators & Support |
| Neth Nom | Fix Animator |
| Tolga Goktekin | VFX Artist |
| Catherine Kelly | Title Designer |
| Louaye Moulayess | Fix Animator |
| Tingting Liu | Fix Animator |
| Nicholas Naugle | Lighting Artist |
| Japeth Pieper | In Memory Of |
| Ernesto Nemesio | Matte Painter |
| Bill Presing | Storyboard Artist |
| Sally Garbarini | Lighting Manager |
| Davide Pesare | Software Engineer |
| Susan Brunig | Color Grading |
| Rebecca Pigg | Human Resources |
| Daniella Muller | Production Assistant |
| Liz Seibert | Production Assistant |
| Courtney Lockwood | Production Coordinator |
| Lauren Montuori | Production Coordinator |
| Rachel Kate Miller | Production Coordinator |
| Jodi S. Miller | Project Manager |
| Edward Luong | Software Engineer |
| Jeremy Cowles | Software Engineer |
