 | Keanu Reeves als Eddie Kasalivich |
 | Morgan Freeman als Paul Shannon |
 | Rachel Weisz als Dr. Lily Sinclair |
 | Fred Ward als FBI Agent Leon Ford |
 | Kevin Dunn als FBI Agent Doyle |
 | Brian Cox als Lyman Earl Collier |
 | Joanna Cassidy als Maggie McDermott |
 | Chelcie Ross als Ed Rafferty |
 | Nicholas Rudall als Dr. Alistair Barkley |
 | Tzi Ma als Lu Chen |
 | Krzysztof Pieczyński als Lucasz Screbneski |
 | Julie Pearl als Emily Pearl |
 | Godfrey als Chidi Egbuna |
 | Gene Barge als James Washington |
 | Nathan Davis als Morris Grodsky |
| Aaron Williams als Lab Techie #3 |
| Daniel H. Friedman als Video Dan |
| Johnny Lee Davenport als Caleb Williams |
 | James Sie als Ken Lim |
| Joan Kohn als Sarah Fine |
 | Juan Ramírez als Raymond Peña |
 | Nydia Rodriguez Terracina als Gabrielle Guerrera |
 | Scott Benjaminson als Stuart Showcroft |
| Ned Schmidtke als Wisconsin Chief Schmidke |
| Randall Arney als DC Technician |
| Noelle Bou-Sliman als DC Technician |
 | Joseph F. Kosala als Sergeant Joe Byczkowski |
 | Ron Dean als Sergeant Nick Zingaro |
| Miguel Nino als Officer Miguel |
 | Turk Muller als Dane County Cop |
 | Neil Flynn als State Trooper Nemitz |
| Michael Skewes als State Trooper Schwartz |
 | Margaret Travolta als Anita Fermi |
| Jacqueline G. Arthur als Jackie Mann |
| Tom Mula als Chicago Administrator |
| Denise Price als Receptionist |
 | Rick LeFevour als Matthew Haig |
| Charley Sherman als Justin Tidy |
| Gina Raffin als Colleen Dryden |
| Pam Zekman als Rita Bliss |
| Lisa Tejero als Dolores Enrique |
 | David Pasquesi als Al Vanzetti |
| John Drummond als Drummond |
| Cathy Herd als TV Reporter |
| Tell Draper als TV Reporter |
 | Danny Goldring als Clancy Butler |
| Eddie Bo Smith Jr. als Yusef Reed |
| Michael Gaylord James als Jim Gaylord |
| Ken Moreno als Naldo Partida |
| Allen Hamilton als Senator Phil Schmidt |
| Dick Cusack als Senate Chairman |
| Nicholas Kusenko als Staff Member Stennis |
| David Michael Gee als Senate Guard |
| Stanley M. Span als Firechief #1 |
 | Ann Whitney als Barkley's Lawyer |
| Rich Komenich als Bar Patron |
| Afram Bill Williams als Bridge Controller |
 | Will Zahrn als Bridge Controller |
| John W. Hardy als Train Porter |
| Mary Seibel als Older Woman on Train |
| Nina Beesley als Flower Shop Owner |
 | Michael Shannon als D.C. Flower Delivery Man |
| Billy Haynes als Doorman |
| Walter Doggett als Gate Guard |
| Jack Kandel als Panhandler |
| Timothy J. Maxwell als Homeless Husband |
| Leslie Mikol als Homeless Wife |
| Rio Zavala als Homeless Man |
 | Mark Morettini als Romano |
| Soseh Kevorkian als Evelyn |
| Christopher Holloway als Max Holloway |
 | Jim Ortlieb als Orbit |
 | Cheryl Hamada als Hamada |
| Mike Gray als Swizlard |
| Joe Guastaferro als Tunnel Foreman |
| Arthur Schmidt | Editor |
| David J. Bomba | Art Direction |
| Josh Friedman | Story |
| J.F. Lawton | Screenplay |
| Richard D. Zanuck | Executive Producer |
| Jerry Goldsmith | Original Music Composer |
| Jerry Goldsmith | Conductor |
| Mark Stevens | Editor |
| Gene Serdena | Set Decoration |
| Erwin Stoff | Executive Producer |
| Roy Arbogast | Special Effects Coordinator |
| Arne Schmidt | Producer |
| Arne Schmidt | Story |
| Craig Berkey | Sound Effects Editor |
| Rick Seaman | Story |
| Jodie Lynn Tillen | Costume Design |
| Maher Ahmad | Production Design |
| Maher Ahmad | Associate Producer |
| Andrew Davis | Director |
| Andrew Davis | Producer |
| Kenneth Hall | Music Editor |
| Dov Hoenig | Editor |
| Walter Scott | Stunt Coordinator |
| Randy Thom | Sound Designer |
| Lowell D. Blank | Post Production Supervisor |
| R. Orlando Duenas | First Assistant Editor |
| R.J. Kizer | ADR Supervisor |
| Don Brochu | Editor |
| Frank Tidy | Director of Photography |
| Michael Bortman | Screenplay |
| Ann Harris | Assistant Art Director |
| Don H. Julien | Production Assistant |
| Arthur Morton | Orchestrator |
| Vanessa Theme Ament | Foley Artist |
| Cliff Fleming | Pilot |
| Matt Earl Beesley | First Assistant Director |
| Matt Earl Beesley | Second Unit Director |
| Terri Douglas | ADR Voice Casting |
| Nick Davis | Visual Effects Supervisor |
| Bob Rose | Key Grip |
| Ric Coken | ADR Recordist |
| Connie Kallos | Makeup Effects |
| Marcie Friedman | Location Coordinator |
| Sarayu Blue | Extras Casting Assistant |
| Alphonse Blumenthal | Gaffer |
| Erica Arvold | Casting Associate |
| David Isyomin | Digital Effects Supervisor |
| Murray Close | Still Photographer |
| David Sanger | Visual Effects Coordinator |
| Richard Fernandez | Set Designer |
| John A. Larsen | Sound Supervisor |
| Frank M. Holgate | Aerial Director of Photography |
| George Kohut | Camera Operator |
| Paul Apted | Assistant Sound Editor |
| David A. Arnold | Dialogue Editor |
| Thom Randmaa | Visual Effects Producer |
| Kirk Corwin | Property Master |
| Fríða Aradóttir | Key Hair Stylist |
| Deena Adair | Hairstylist |
| Bruce J. Gfeller | Construction Coordinator |
| David E. Stone | Supervising Sound Editor |
| John J. Slove Jr. | Propmaker |
| Stephen Lim | Unit Production Manager |
| Kenneth C. Mantlo | Boom Operator |
| Jeffrey Kalmus | Color Grading |
| Cliff Latimer | ADR Editor |
| Michael Hancock | Makeup Artist |
| Timothy Burgard | Storyboard Artist |
| Teresa Tucker-Davies | Associate Producer |
| Anthony Medina | Art Department Production Assistant |
| Carlos H. Sánchez | Associate Producer |
| Daniel H. Friedman | Video Assist Operator |
| Patrick Caulfield | Set Costumer |
| Jane Blank | Costumer |
| John P. Friday | Rigging Gaffer |
| Joan Philo | Extras Casting |
| Don Riozz McNichols | Key Special Effects |
| Deborah Simmrin | Unit Publicist |
| Alexandria Forster | Costume Supervisor |
| Gina Panno | Key Set Costumer |
| Morgan Michael Lewis | Key Rigging Grip |
| Joni Avery | Stunts |
| Kathleen Beall | Location Scout |
| Bob Putynkowski | Color Timer |
| George DiLeonardi | Transportation Coordinator |
| Scott Baehrend | Rigging Grip |
| B. Ted Deiker | Assistant Production Coordinator |
| William Morts | Stunt Double |
| Anthony J. Lullo | Best Boy Electric |
| Kieran Woo | Production Controller |
| Brady Breen | Location Assistant |
| Robert J. Anderson Jr. | Sound Mixer |
| Donah Bassett | Negative Cutter |
| James Reedy | Special Effects Supervisor |
| Sonny Pettijohn | First Assistant Sound Editor |
| John Mikels | Standby Painter |
| Ken Cabrera | Craft Service |
| Carlos Medina Jr. | Greensman |
| Steven Silverstein | Camera Loader |
| Andre Bustanoby | VFX Artist |
| Erin Michelle Hopkins | Assistant Editor |
| Michael Salven | Key Set Production Assistant |
| Fernando M. Briones | Dolly Grip |
| Laurence Byrne | Assistant Location Manager |
| Tommy Dorsett | Visual Effects Editor |
| Dana Armonda | Art Department Coordinator |
| Joel Prihoda | Leadman |
| James Cimbalista | Painter |
| Donald Carlson | First Assistant Camera |
| Dennis De La Mata | Grip |
| Jacqueline S. Beatka | Seamstress |
| Tighe Barry | Set Dressing Artist |
| Frank Battaglia | Carpenter |
| Justine A. Bello | Post Production Assistant |
| Jeff Manimbo | Production Intern |
| D.B. Griffith | Projection |
| Janet L. Contursi | Set Medic |
| Gregory Cheever | Sound Recordist |
| Gina Aponte | Stand In |
| William T. Hogan III | Transportation Captain |
| Michael P. Deal | Transportation Co-Captain |
| Kent Shelton | Utility Stunts |
| Renée Bergan | Editorial Production Assistant |
| Lawrence J. Anderson Jr. | Electrician |
| K. Lenna Katich | Production Accountant |
| Lisa A. Becker | Production Coordinator |
| Dennis Davis | Digital Compositors |
| Troy Borisy | Assistant Property Master |
| John S. Robertson | Key Grip |
| Patricia S. Kingery | Payroll Accountant |
| Suzanne De Grandis | First Assistant Accountant |
| Matt Codd | Conceptual Illustrator |
| Michael Ahasay | Special Effects Technician |
| Gregg Gannett | Second Assistant Camera |
| Ken Paull | Second Assistant Director |
| James A. Dennett II | Second Second Assistant Director |
| Chuck Rapp | ADR Mixer |
| Karin Roulo | Foley Mixer |
| Sandy Garcia | Foley Recordist |
| Russell j Lyster | VFX Director of Photography |
| Andrew Garcia-Price | Visual Effects Production Assistant |
| Erich O. Rose | Best Boy Grip |
| Jean Nakahara | Post Production Coordinator |
| Malisa Caroselli | Assistant Accountant |
| Karin Anderson | Assistant Craft Service |
| Joseph M. Brennan | Technical Advisor |
