 | Catherine Hicks als Karen Barclay |
 | Chris Sarandon als Mike Norris |
 | Alex Vincent als Andy Barclay |
 | Brad Dourif als Chucky (voice) / Charles Lee Ray |
 | Dinah Manoff als Maggie Peterson |
 | Tommy Swerdlow als Jack Santos |
 | Jack Colvin als Dr. Ardmore |
 | Neil Giuntoli als Eddie Caputo |
 | Juan RamÃrez als Peddler |
 | Alan Wilder als Mr. Criswell |
 | Richard Baird als News Reporter at Toy Store |
| Ray Oliver als Dr. Death |
| Aaron Osborne als Orderly |
| Tyler Hard als Mona |
| Ted Liss als George |
| Roslyn Alexander als Lucy |
 | Bo Kane als Male TV Newscaster |
| Leila Lee Olsen als Female TV Newscaster |
| Lena Sack als Bellevue Patient |
| Tommy Gerard als Bellevue Patient |
| Michael Chavez als Bellevue Patient |
| Jamie Gray als Bellevue Patient |
| Erin Munz als Bellevue Patient |
| Jana Twomey als Bellevue Patient |
| Suaundra Black als Bellevue Patient |
 | Edan Gross als Friendly Chucky / Kid in Animated Commercial (voice) |
 | John Franklin als Walkabout Chucky (voice) |
| Michael Patrick Carter als Kid in Animated Commercial (voice) |
| Don Mancini | Screenplay |
| John Lafia | Screenplay |
| Tom Holland | Screenplay |
| David Kirschner | Producer |
| Joe Renzetti | Original Music Composer |
| Bill Butler | Director of Photography |
| Roy E. Peterson | Editor |
| Edward Warschilka | Editor |
| Dennis Scott | Stunts |
| Tom Holland | Director |
| Sharon Bialy | Casting |
| Richard Pagano | Casting |
| Daniel A. Lomino | Production Design |
| Cloudia Rebar | Set Decoration |
| April Ferry | Costume Design |
| Michael Hancock | Makeup Artist |
| Marina Pedraza | Hairstylist |
| Barrie M. Osborne | Executive Producer |
| Peter Donen | Visual Effects Supervisor |
| Harry Cheney | Sound Editor |
| John Riordan | Supervising Sound Editor |
| Kirk Schuler | Sound Editor |
| Sherman Waze | Sound Editor |
| Laura Moskowitz | Associate Producer |
| Elliot Geisinger | Co-Executive Producer |
| Don Mancini | Story |
| Robert Latham Brown | Unit Production Manager |
| Carl Olsen | Unit Production Manager |
| Arthur Anderson | Insert Unit First Assistant Director |
| Bud Davis | Second Unit Director |
| George Fortmuller | Second Assistant Director |
| James Giovannetti Jr. | Second Unit First Assistant Director |
| Michael Green | First Assistant Director |
| Linnea Ebba Wicklund | Second Assistant Director |
| William Arnold | Set Designer |
| Gary Baugh | Set Designer |
| Earl Benton | Standby Painter |
| Bernard P. Cutler | Assistant Art Director |
| William D'Ambra | Property Master |
| Edward England | Construction Coordinator |
| Casey Hallenbeck | Leadman |
| Joann Hicks | Assistant Property Master |
| James F. Orendorff | Construction Coordinator |
| Joel Prihoda | Leadman |
| Kenneth Robertson | Paint Coordinator |
| Francis J. Roix | Carpenter |
| Arthur Shippee | Property Master |
| Timothy W. Tiedje | Set Dresser |
| James E. Tocci | Set Designer |
| David Gianneschi | Swing |
| Robert E. Knight | Scenic Artist |
| Pete von Sholly | Storyboard Artist |
| Clayton Collins | Sound Editor |
| John Cousineau | Assistant Sound Editor |
| Franklin Jones Jr. | Sound Re-Recording Mixer |
| Rick Kline | Sound Re-Recording Mixer |
| Cheryl Kroll | Assistant Sound Editor |
| Donald O. Mitchell | Sound Re-Recording Mixer |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Ronald Sinclair | ADR Editor |
| George Steven | ADR Editor |
| Douglas Vaughan | Boom Operator |
| James E. Webb | Sound Mixer |
| Dan Yale | Sound Editor |
| Marty Church | Foley Mixer |
| Ellen Heuer | Foley Artist |
| Jack Keller | Sound Recordist |
| Greg Orloff | Foley Mixer |
| John Roesch | Foley Artist |
| Joseph T. Sabella | Foley Artist |
| Becky Sullivan | Supervising ADR Editor |
| Don Summer | Sound Mixer |
| Carolyn Tapp | Foley Recordist |
| Scott A. Tinsley | Foley Editor |
| Dan Yale | Dialogue Editor |
| Glory Fioramonti | Stunts |
| Bud Davis | Stunt Coordinator |
| Anthony Cecere | Stunts |
| Bob K. Cummings | Stunts |
| Eddie J. Fernandez | Stunts |
| Joie Chitwood Jr. | Stunts |
| James Fierro | Stunts |
| Rick LeFevour | Stunts |
| Joe Gilbride | Stunts |
| Carl Paoli | Stunts |
| Stacy Logan | Stunts |
| Kay Whipple | Stunts |
| Debbie Lynn Ross | Stunts |
