 | Adam Sandler als Michael Newman |
 | Kate Beckinsale als Donna Newman |
 | Christopher Walken als Morty |
 | David Hasselhoff als Ammer |
 | Henry Winkler als Ted |
 | Julie Kavner als Trudy |
 | Sean Astin als Bill |
 | Joseph Castanon als Ben at 7 years old |
 | Jonah Hill als Ben at 17 years old |
 | Jake Hoffman als Ben at 22-30 years old |
 | Tatum McCann als Samantha at 5 years old |
 | Lorraine Nicholson als Samantha at 14 years old |
 | Katie Cassidy als Samantha at 27 years old |
 | Cameron Monaghan als Kevin O'Doyle |
 | Jennifer Coolidge als Janine |
 | Rachel Dratch als Alice / Alan |
 | Sophie Monk als Stacy |
 | Michelle Lombardo als Linda |
 | Jana Kramer als Julie |
 | Nick Swardson als Bed, Bath & Beyond Guy |
 | Sidney Ganis als Dr. Bergman |
 | Michael Yama als Watsuhita Head Executive |
| Mio Takada als Watsuhita Executive |
| Eiji Inoue als Watsuhita Executive |
 | Toshi Toda als Watsuhita Executive |
| George K. Eguchi als Ancient Executive |
| Katheryn Cain als Kirsten |
 | Frank Coraci als Male Nurse |
 | Tim Herlihy als Doctor |
 | Iryna Blokhina als Jogger |
| Emilio Cast als Michael at 10 Years Old |
 | Willy Goldstein als Lakeside Camp Boy |
 | Lily Mo Sheen als Lakeside Camp Girl |
 | Carolyn Hennesy als Kathy O'Doyle |
| Elena Patten als Samantha's Friend |
 | Cheyenne Alexis Dean als Samantha's Friend |
 | Elliott Cho als Ping Woo |
| Alan Au als Ping Woo's Father |
| Ryan Keiser als Firecracker Teen |
| Christopher Levy als Firecracker Teen |
| Nickole Reyes als Firecracker Teen |
| Brianna Davis als Firecracker Teen |
| Robert Jones als Firecracker Teen |
 | Jenae Altschwager als Judy |
| Manish Goyal als Habeeboo Entourage |
 | Marco Khan als Habeeboo Entourage |
| Ahmad Jordan als Habeeboo Entourage |
| Nick Hodaly als Habeeboo Entourage |
| Alireza Tanbakoochi als Habeeboo Entourage |
| John Pagano als Bandleader |
 | Dolores O'Riordan als Singer |
| Sally Insul als Aunt Peggy |
 | Rob Schneider als Prince Habeeboo (uncredited) |
 | Billy Slaughter als Newman Employee (uncredited) |
 | James Earl Jones als Narrator of Michael's Past (voice) |
 | Theresa Barrera als Susie (uncredited) |
 | Elizabeth DeCicco als Hot Assistant (uncredited) |
| Abra Chouinard als Hot Employee (uncredited) |
 | Terry Crews als Singing Driver |
 | Howard Fong als Ping Woo's Grandfather (uncredited) |
 | Jorge Garcia als Ammer in SAP scene (uncredited) |
| Tracy Britton als Office Worker (uncredited) |
 | Jason Sandler als Best Man (uncredited) |
 | Celeste Thorson als Punk Chick (uncredited) |
 | Lana Titov als Wedding Guest (uncredited) |
| Frank Coraci | Director |
| Barry Bernardi | Executive Producer |
| Jack Giarraputo | Producer |
| Tim Herlihy | Executive Producer |
| Steve Koren | Producer |
| Neal H. Moritz | Producer |
| Mark O'Keefe | Producer |
| Adam Sandler | Producer |
| Rupert Gregson-Williams | Original Music Composer |
| Dean Semler | Director of Photography |
| Jeff Gourson | Editor |
| Roger Mussenden | Casting |
| Steve Koren | Writer |
| Mark O'Keefe | Writer |
| Kazu Hiro | Prosthetic Supervisor |
| Perry Andelin Blake | Production Design |
| Michael Dilbeck | Music Supervisor |
| Brooks Arthur | Music Supervisor |
| Rick Baker | Special Effects Makeup Artist |
| Ellen Lutter | Costume Design |
| Paul Eliopoulos | Stunt Coordinator |
| J. Mark Donaldson | Stunts |
| Michael H. Barnett | Stunts |
| J.J. Perry | Stunts |
| Max Daniels | Stunts |
| Nathan Siebring | Stunts |
| Vanessa Motta | Stunts |
| Daryl Kass | Unit Production Manager |
| Josh King | First Assistant Director |
| Marcei A. Brown | Second Assistant Director |
| Jim Rygiel | Visual Effects Designer |
| Peter G. Travers | Visual Effects Supervisor |
| Tania Landau | Co-Producer |
| Kevin Grady | Co-Producer |
| Aimee Keen | Associate Producer |
| Alan Au | Art Direction |
| Jeff Mossa | Art Direction |
| Gary Fettis | Set Decoration |
| Timothy S. Wiles | Property Master |
| Nancy Karlin | Script Supervisor |
| Ian Fox | "A" Camera Operator |
| Tony Rivetti Sr. | First Assistant "A" Camera |
| Chad Rivetti | Second Assistant "A" Camera |
| Richard Merryman | "B" Camera Operator |
| Fred L. McLane | First Assistant "B" Camera |
| Roger Wall | Second Assistant "B" Camera |
| Megan Forste | Second Assistant "B" Camera |
| Jessica Peel | Assistant Costume Designer |
| Valerie Zielonka | Costume Supervisor |
| Sanford Slepak | Key Costumer |
| Lori Harris | Costumer |
| Andrew Slyder | Costumer |
| Mary Iannelli | Costumer |
| Ann Pala | Makeup Department Head |
| Kathleen Freeman | Key Makeup Artist |
| Corina C. Duran-Rabichuk | Makeup Artist |
| Bill Corso | Prosthetic Makeup Artist |
| Thomas Real | Hair Department Head |
| Nancy Tong | Key Hair Stylist |
| James J. Gilson | Chief Lighting Technician |
| Joe Martens | Assistant Chief Lighting Technician |
| William 'Bear' Paul | Key Grip |
| Craig Riley Jr. | Best Boy Grip |
| Jeff 'Moose' Howery | Dolly Grip |
| John W. Murphy | Dolly Grip |
| Kim Heath | Key Rigging Grip |
| Thomas Causey | Production Sound Mixer |
| Joseph F. Brennan | Boom Operator |
| Linda Murphy | Boom Operator |
| David Katz | Video Assist Operator |
| John Hartigan | Special Effects Coordinator |
| Ralph Coleman | Location Manager |
| Rob Frank | Assistant Location Manager |
| Jason Tamez | Production Coordinator |
| Georgina Marquis | Assistant Production Coordinator |
| Michael M. Piehler | Production Secretary |
| Rita Smith | Production Secretary |
| Gwen Everman | Production Accountant |
| Elizabeth A. Bergman | Assistant Accountant |
| David Elliott | Construction Coordinator |
| Bill 'Kauhane' Hoyt | Standby Painter |
| John Collins | Assistant Art Director |
| Evelyne Barbier | Set Designer |
| Cosmas A. Demetriou | Set Designer |
| Jeff Markwith | Set Designer |
| Hugo Santiago | Set Designer |
| Dru Homer | Art Department Coordinator |
| William Eliscu | Graphic Designer |
| Eric Ramsey | Storyboard Artist |
| Pete von Sholly | Storyboard Artist |
| David C. Potter | Leadman |
| Chuck Askerneese | Assistant Property Master |
| Tammy Sandler | Unit Publicist |
| Tracy Bennett | Still Photographer |
| Marisa Ferrey | Second Second Assistant Director |
| Pamela Lynn Thomas | Casting Associate |
| Melissa Kostenbauder | Casting Assistant |
| Chris Bustard | Extras Casting |
| Jeni Thornell | Extras Casting |
| Charlie Scott | Craft Service |
| Pat Jackson | Studio Teacher |
| Edward Flotard | Transportation Captain |
| Juan J. Rodriguez | Transportation Co-Captain |
| Patsy Bouge | Post Production Supervisor |
| Tamara McDonough | Additional Editing |
| Morgan Davis Foehl | Assistant Editor |
| Terry Hubbard | Assistant Editor |
| Elmo Weber | Supervising Sound Editor |
| David Bach | Supervising Sound Editor |
| Marc Glassman | Sound Effects Designer |
| Russell Farmarco | Supervising ADR Editor |
| Matthew P. Hanson | Assistant Sound Editor |
| Cameron Steenhagen | Dialogue Editor |
| David V. Butler | Dialogue Editor |
| Orada Jusatayanond | Sound Effects Editor |
| Clayton Weber | Sound Effects Editor |
| Mark Allen | Sound Effects Editor |
| Dennis Patterson | Foley Supervisor |
| Gary A. Hecker | Foley Artist |
| Michael J. Broomberg | Foley Artist |
| Brian Ruberg | Foley Mixer |
| Howard London | ADR Mixer |
| Jeffrey J. Haboush | Sound Mixer |
| Bill W. Benton | Sound Mixer |
| J.J. George | Music Editor |
| Stuart Grusin | Music Editor |
| Michael T. Ryan | Music Editor |
| Kevin Crehan | Music Editor |
| Blake Neely | Conductor |
| David Taritero | Visual Effects Producer |
| Armen Ksajikian | Musician |
| Paul Eliopoulos | Stunt Double |
| Thomas J. Larsen | Stunts |
