 | Matt Ryan als John Constantine / Constantine-Demons (voice) |
 | Robin Atkin Downes als Nergal (voice) |
 | Laura Bailey als Trish / Asa the Healer (voice) |
 | Rachel Kimsey als Angela (voice) |
 | Jim Meskimen als Beroul / Cheleb / Quedbas (voice) |
 | Emily O'Brien als Renee Chandler (voice) |
 | Damian O'Hare als Chas Chandler / Amainon / Decarabia (voice) |
 | Kevin Michael Richardson als Mahonin / Old Man (voice) |
 | Rick D. Wasserman als Mictlantecuhtli (voice) |
| Doug Murphy | Director |
| Kyle Stafford | Editor |
| Marc Guggenheim | Executive Producer |
| Liz Marshall | Executive Producer |
| Greg Berlanti | Executive Producer |
| Sam Register | Executive Producer |
| J. M. DeMatteis | Writer |
| Sarah Schechter | Executive Producer |
| David S. Goyer | Executive Producer |
| Butch Lukic | Producer |
| Phillip Bourassa | Art Direction |
| Kevin Riepl | Original Music Composer |
| J. M. DeMatteis | Characters |
| Jamie Delano | Characters |
| John Ridgway | Characters |
| Philip Tan | Characters |
| Wes Gleason | Casting |
| John Totleben | Characters |
| Alan Moore | Characters |
| Steve Bissette | Characters |
