 | Marion Cotillard als Leonora Orantes |
 | Matt Damon als Mitch Emhoff |
 | Laurence Fishburne als Ellis Cheever |
 | Jude Law als Alan Krumwiede |
 | Kate Winslet als Erin Mears |
 | Jennifer Ehle als Ally Hextall |
 | Gwyneth Paltrow als Beth Emhoff |
 | Bryan Cranston als Lyle Haggerty |
 | Elliott Gould als Ian Sussman |
 | Chin Han als Sun Feng |
 | John Hawkes als Roger |
 | Anna Jacoby-Heron als Jory Emhoff |
 | Sanaa Lathan als Aubrey Cheever |
 | Demetri Martin als David Eisenberg |
 | Armin Rohde als Damian Leopold |
 | Enrico Colantoni als Dennis French |
 | Larry Clarke als Dave |
 | Monique Gabriela Curnen als Lorraine Vasquez |
 | Daria Strokous als Irina |
 | Rick Uecker als Minnesota Health |
| Jamie Newell als Siphon Woman (uncredited) |
 | Griffin Kane als Clark Morrow |
 | Rebecca Spence als Jon Neal's Wife |
 | Yoshiaki Kobayashi als Japanese Bus Man |
| Teri McEvoy als School Nurse |
 | Sue Redman als ER Nurse #1 |
| Teri Campbell als ER Nurse #2 |
 | Stef Tovar als Dr. Arrington |
 | Mary Jo Faraci als Social Worker |
 | Grace Rex als Carrie Anne |
 | Joseph Anthony Foronda als WHO Official |
 | Annabel Armour als Beth's Mother |
 | Jim Ortlieb als Funeral Director |
 | Kara Zediker als Elizabeth Nygaard |
 | Laura Fisher als Sick Lady |
 | Mary Beth Dolan als Nun |
 | Dan Flannery als Hextall's Father |
 | Jason Babinsky als Shivering Man |
| Howie Johnson als Morgue Worker |
| Sanjay Gupta als Sanjay Gupta |
 | Chui Tien-You als Li Fai |
 | Josie Ho als Li Fai's Sister |
 | Steven Soderbergh als John Neal (voice, uncredited) |
 | Phillip James Brannon als Paramedic |
| David Lively als Minnesota Medical Examiner |
| Andrew White als Assistant Medical Examiner |
| Ira Blumen als Helpful Doctor |
| Scott Stangland als Minnesota Health #1 |
| Jimmy Chung als Minnesota Health #2 |
| Tara Mallen als Minnesota Health #4 |
| John Hines als AIMM Employee #1 |
| Joshua Weinstein als AIMM Employee #2 |
 | Sarah Charipar als AIMM Employee #3 |
| Mark Czoske als AIMM Employee #4 |
| Dan Aho als Aaron Barnes |
| Hee-Wan Kwon als Japanese Official |
| Phil Tang als Village Man #1 |
| Robert Chi als Village Man #2 |
| Blair Robertson als Sussman's Assistant |
| Randy Lowell als Hedge Fund Man in Park |
| Pete Sack als TV Anchor |
| Brian J. O'Donnell als Andrew |
| Kwok-Wah Wong als Chinese Health Official #1 |
| Sau-Ming Tsang als Chinese Health Official #2 |
| Josh Pollock als Coughing Man |
 | Peter A Kelly als National Guardsman |
| Thomas Gebbia als Man with Megaphone |
| Dan Sanders-Joyce als Home Invasion Thug |
| Joshua Seiden als Anthony |
| Kam Tong Wong als Chef |
| Jim Anderson als Police Officer (uncredited) |
 | Bambadjan Bamba als Dread (uncredited) |
| Rodolfo C Barrios als Sick Guy (uncredited) |
| Bryan Basil als Senate Staffer (uncredited) |
| Raphael Baunaquis als Police Officer (uncredited) |
 | Ahmed Boulane als Doctor Haddad (uncredited) |
 | Liz Clare als Vaccine Recipient (uncredited) |
| Rashida Clendening als Interviewee (uncredited) |
 | David Cohen als News Reporter (uncredited) |
| James Anthony Cotton als Tough Guy (uncredited) |
 | Duke Czlonka als National Guard Sergeant (uncredited) |
 | Andrew Dasz als Airport Passager (uncredited) |
| Joe DeBartolo als Food Drop Recipient (uncredited) |
| Eduardo Ambriz DeColosio als Interviewee (uncredited) |
| Amanda Dyar als Vaccinated Citizen (uncredited) |
| Ryan Ebert als Sick Person (uncredited) |
| Shannon Edwards als Michael Giannes - Minnesota Health Department (uncredited) |
 | Anas El Baz als Ahraf (uncredited) |
| Olivia Francessca als Nurse (uncredited) |
| Logan Fry als Washington D.C. Lobbyist (uncredited) |
| Kenley Gaffke als Vaccine Patient (uncredited) |
| Christian Heep als Reporter (uncredited) |
 | Alex Hill 3 als Press Room Reporter (uncredited) |
 | John Hoogenakker als Rafik's Lawyer (uncredited) |
| Matt Iwinski als Photographer (uncredited) |
| Sarah Kliban als Interviewee (uncredited) |
| Iris Kohl als Reporter (uncredited) |
| Suzanne Lang als ER Nurse (uncredited) |
 | Elester Latham als Doctor (uncredited) |
 | Mark Lavell als Survivor (uncredited) |
| Ina Lereine als Pedestrian (uncredited) |
| Seth Leslie als Stage Performer (uncredited) |
 | John Lobato als Sickly Victim (uncredited) |
| Patterson Lundquist als Concerned Citizen (uncredited) |
| Josiah Lyricq als Protestor (uncredited) |
| Mino Mackic als Airport Businessman (uncredited) |
 | Carl Marino als Pharmacy Fighter (uncredited) |
 | Mary Lu Marr als Physician (uncredited) |
| James Mastel als FBI Agent (uncredited) |
| Timothy W. Mather als Print Journalist (uncredited) |
| Thomas McCormick als Photographer (uncredited) |
| Dave McNulty als Doctor in Lobby (uncredited) |
 | E. Roger Mitchell als Driver (uncredited) |
 | Paul D. Morgan als Hazmat Doctor (uncredited) |
| Jesse Muick als Vaccine Recipient (uncredited) |
| Larry Nazimek als CDC Employee (uncredited) |
| Andrew Nitzke als Epidemic Victim (uncredited) |
 | Matthew Parry-Jones als Sick Child (uncredited) |
| Eric Pierson als Driver (uncredited) |
| Steven Potts als Sick Man (uncredited) |
| Steven James Price als Lt. Col Ginsberg (uncredited) |
| Kyle Quesnoy als Redhead Interviewee (uncredited) |
| Brandi Quinn als Sickly Victim (uncredited) |
| Kenya Robertson als Waitress (uncredited) |
 | Joshua Rollins als Reporter (uncredited) |
| Sandy Rouge als Medical Staff (uncredited) |
 | Helen Sadler als Polish Maid (uncredited) |
| Peggy Sandow als Sick Woman (uncredited) |
 | Jane Santos als Survivor (uncredited) |
| Hester Schell als Epidemic Victim (uncredited) |
| Jon Komp Shin als On Air News Reporter San Francisco (uncredited) |
 | Walt Sloan als Hospital Physician (uncredited) |
| Gregory Marshall Smith als CDC Reporter / Health Official (uncredited) |
| Ylian Alfaro Snyder als Sick Citizen (uncredited) |
| Joshua Squire als Vaccine Patient (uncredited) |
 | January Stern als Congress Woman (uncredited) |
 | Michael T Stewart als Citizen (uncredited) |
| Thomas W. Stewart als Doctor (uncredited) |
| Audra Todd als CDC Employee (uncredited) |
 | Giota Trakas als Reporter (uncredited) |
 | Ken Venzke als On Air Reporter San Francisco Channel 7 (uncredited) |
| Abby Wait als Girl In Cafe (uncredited) |
 | Amr Waked als Rafik (uncredited) |
 | James D. Weston II als FBI Agent (uncredited) |
 | Roger Wiggins als CDC Employee (uncredited) |
| Robert A. Young als Capital Police (uncredited) |
| Bobby Watson als Dying Man (uncredited) |
| David Lazan | Supervising Art Director |
| Cliff Martinez | Original Music Composer |
| Steven Soderbergh | Director |
| Steven Soderbergh | Director of Photography |
| Stephen Mirrione | Editor |
| Cindy Carr | Set Decoration |
| Louise Frogley | Costume Design |
| Michael Shamberg | Producer |
| Stacey Sher | Producer |
| Michael Polaire | Executive Producer |
| Howard Cummings | Production Design |
| Jonathan King | Executive Producer |
| Stephan Dupuis | Key Makeup Artist |
| Nina Henninger | Casting |
| Scott Z. Burns | Screenplay |
| Jeff Skoll | Executive Producer |
| Carmen Cuba | Casting |
| David Betancourt | Foley Mixer |
| Scott Curtis | Foley Mixer |
| Dawn Lunsford | Foley Artist |
| Alicia Stevenson | Foley Artist |
| Nancy Cavallaro | Costumer |
| Ricky Strauss | Executive Producer |
| Zakaria Alaoui | Line Producer |
| Stephanie Gilliam | Assistant Art Director |
| Susan Hegarty | Dialect Coach |
| Dominic Mango | Key Hair Stylist |
| Kay Georgiou | Hairstylist |
| Gregory Jacobs | Producer |
| Gregory Jacobs | First Assistant Director |
| Chen On Chu | Line Producer |
| Heath Winn | Special Effects Technician |
| Florian Nussbaumer | Second Assistant Director |
| Kate Biscoe | Makeup Department Head |
| Tiago Santos | Compositor |
| David A. Whittaker | Dialogue Editor |
| Claudette Barius | Still Photographer |
| Paul Lavoie | Digital Intermediate Producer |
| Michael Primmer | Boom Operator |
| Merje Veski | Assistant Art Director |
| Suzi Ostos | Key Makeup Artist |
| Brad Einhorn | Property Master |
| Larry Blake | Supervising Sound Editor |
| Larry Blake | Sound Re-Recording Mixer |
| Amy Newbold | Casting Assistant |
| David Tennenbaum | Set Designer |
| Lisa Nichols | Studio Teacher |
| Emma Fletcher | Casting Associate |
| Javier M. Hernández | Boom Operator |
| Jinnie Pak | Visual Effects Producer |
| Jeanie Baker | Key Set Costumer |
| Michele C. Vallillo | Visual Effects Producer |
| Annie Welles | Script Supervisor |
| Thomas J. Smith | Visual Effects Supervisor |
| Bill Marinella | Extras Casting |
| Abdellah Baadil | Art Direction |
| Robert J. Carlyle | Construction Coordinator |
| Duane Manwiller | Camera Operator |
| Abderrahim Bissar | Electrician |
| Darin McCormick-Millett | Title Designer |
| Shari Ratliff | Art Department Coordinator |
| Spooky Stevens | Publicist |
| Nat Jencks | First Assistant Editor |
| Nat Jencks | Additional Visual Effects |
| Aaron Schultz | CG Artist |
| Iliana Sanchez | Set Costumer |
| Richard Schoen | Costume Supervisor |
| Simon Dobbin | Art Direction |
| Fríða Aradóttir | Hair Department Head |
| Laurel Kelly | Key Hair Stylist |
| Samuel Wong | Key Hair Stylist |
| Fannie Chan | Key Makeup Artist |
| David Brown | Production Manager |
| Francine Lusser | Production Manager |
| Johnny Wang | Production Manager |
| Carrie Yiu | Art Department Coordinator |
| Aaron Shores | Construction Coordinator |
| Tyler Osman | Construction Coordinator |
| Bruce Hui | Construction Coordinator |
| Aaron Brown | Compositor |
| John Nicolard | Digital Intermediate |
| Matt Coby | Dialogue Editor |
| Ron Bolanowski | Special Effects Coordinator |
| Michael D. Gianneschi | Assistant Property Master |
| Jennifer Jobst | Costume Supervisor |
| Tom Cummins | Key Set Costumer |
| Jason Wardle | CG Artist |
| Andrea C. Brotherton | Hairstylist |
| Randy Goux | Visual Effects Supervisor |
| Sarah Mays | Makeup Artist |
| Thomas Terhaar | Hairstylist |
| David Soukup | Set Dresser |
| Rachid Quiat | Set Dresser |
| Steven Meizler | First Assistant "A" Camera |
| Lark Bernini | Production Coordinator |
| David W. Krummel | Set Designer |
| Claire Simon | Casting |
| Philip Beckner | Digital Intermediate |
| Russell Kennedy | First Assistant Camera |
| Didier Lebel | Key Grip |
| Robb Earnest | Production Coordinator |
| Laura Kaminski | Set Costumer |
| James W. Apted | First Assistant "B" Camera |
| Brian Ufberg | Assistant Editor |
| Byron Wilson | Dialogue Editor |
| John D. Milinac | Special Effects Coordinator |
| Heather Elisa Hill | Digital Producer |
| Dennis Towns | Sound mixer |
| Billy Theriot | Assistant Sound Editor |
| David Rosenthal | I/O Supervisor |
| Mark Weingarten | Sound mixer |
| Chris Glomp | Grip |
| Bret August Tanzer | Graphic Designer |
| John Daro | Digital Intermediate Colorist |
| Greg Fausak | Best Boy Grip |
| Michael Sean Foley | CG Supervisor |
| David Rey | Compositor |
| Richard Daldry | Production Coordinator |
| Madalena Chan | Casting |
| Karen Teneyck | Graphic Designer |
| Henry Cantor | Electrician |
| Ken Ryan | Production Accountant |
| Elizabeth Chambers | Travel Coordinator |
| David 'Louie' Lukasik | Rigging Gaffer |
| Valerie T. O'Brien | Key Costumer |
| Jami Primmer | Set Designer |
| Paul Toomey | Second Assistant "A" Camera |
| Rich King | Extras Casting |
| Heidi Erl | Production Coordinator |
| Mimi Palazon | Special Effects Makeup Artist |
| Calvin Tsoi | Assistant Property Master |
| Brittany McLeod | Set Costumer |
| Andrea Pino | Makeup Artist |
| Yann Mari Faget | Second Assistant Director |
| Trey Batchelor | Second Assistant Director |
| John Joseph Minardi | Key Grip |
| Aimee Lippert | Makeup Artist |
| Amanda Vinopal | Costumer |
| Michael Franck | Pilot |
| Stella Cottini | Key Costumer |
| Maria O'Reilly | Makeup Artist |
| James Kumarelas | Rigging Gaffer |
| Karl Coyner | Visual Effects Technical Director |
| Rasha Shalaby | Matte Painter |
| John S. Robertson | Rigging Grip |
| Peter Walts | Chief Lighting Technician |
| Bill Schultz | Digital Intermediate |
| Tim Guffin | Second Assistant "B" Camera |
| David Santiago | Visual Effects Technical Director |
| Jack Rogers | Scenic Artist |
| Louis Jong | Key Grip |
| Chun-Shing Lam | Assistant Chief Lighting Technician |
| Chun-Wan Lam | Chief Lighting Technician |
| Dan Bell | Stunts |
| Ahmed Hatimi | First Assistant Director |
| Man Fong | Production Accountant |
| Feyon Li | Production Secretary |
| Jade E. Chatham | Assistant Editor |
| Monika Sloan | Utility Stunts |
| Liz Probst | Payroll Accountant |
| Widad Taha | Production Coordinator |
| Ross Lee | Production Coordinator |
| Jody Spilkoman | Second Assistant Director |
| Jonelle Castillo | Production Secretary |
| Isobel Thomas | Production Coordinator |
| Aaron Ho | Extras Casting Assistant |
| Daria V. Wright | Makeup Artist |
| Stephanie Logan | Production Secretary |
| Spencer M. Rohan | Rigging Grip |
| Wai Kei Cheng | Second Assistant Director |
| Samar Pollitt | Second Assistant Director |
| Lemon Liu | First Assistant Director |
| Hiromi Marder | Payroll Accountant |
| Carolyn Lassek | Assistant Property Master |
| Nikki Lau Siu-Shu | Second Assistant Director |
| Ira Blumen | Technical Advisor |
| Daniela Tully | Production Executive |
| Rosalind Jones-Crosby | Assistant Hairstylist |
| Felix Rivera | Assistant Chief Lighting Technician |
| Gary Dempsey | Painter |
| Gunter Anderson | Special Effects Technician |
| Holland Markis | Hairstylist |
| Alma Izquierdo | Makeup Artist |
| Wa-wai Luk | Best Boy Grip |
| Ivan Kadlec | Camera Technician |
| Jason Storandt | Dolly Grip |
| Billy Ko | First Assistant "B" Camera |
| Daniel A. Guerrero | Rigging Gaffer |
| Wilson Mylander | Rigging Grip |
| Hunter Whalen | Second Assistant "B" Camera |
| Shaun Braswell | Second Assistant Camera |
| David Ronan | Assistant Property Master |
| Andy Au | Property Master |
| James Bryant Wactor | Prop Maker |
| Jason Lam | Set Designer |
| David Brennan | Set Dresser |
| Becca McCracken | Casting Associate |
| Katrina Wandel George | Casting Associate |
| Lanbo Cheuk | First Assistant Director |
| Cheuk Pan Lee | Second Assistant Director |
| Kuong Tat Wong | Special Effects Coordinator |
| Alex Gitler | Compositing Supervisor |
| Hiroki Iijima | Compositor |
| Wai Wing Tong | Assistant Editor |
| Matt Gruber | Sound Re-Recording Mixer |
| Angus Mak | Utility Sound |
| Elizabeth Hurley | Accountant |
| Abde Sallam Ait Abdellah | Production Accountant |
| Erik Andreasen | Production Executive |
| Heather Gothie | Production Secretary |
| Gabe de Kelaita | Set Production Assistant |
| Billy Goldberg | Technical Advisor |
| Natasha K. Griffith | Technical Advisor |
| Tracey McNamara | Technical Advisor |
