 | Sarah Polley als Ana |
 | Ving Rhames als Kenneth |
 | Ty Burrell als Steve |
 | Inna Korobkina als Luda |
 | Jake Weber als Michael |
 | Michael Kelly als C.J. |
 | Kim Poirier als Monica |
 | Mekhi Phifer als Andre |
 | Matt Frewer als Frank |
 | Kevin Zegers als Terry |
 | Lindy Booth als Nicole |
 | Jayne Eastwood als Norma |
 | Boyd Banks als Tucker |
 | R.D. Reid als Glen |
 | Louis Ferreira als Luis |
 | Bruce Bohne als Andy |
 | Hannah Lochner als Vivian |
 | Michael Barry als Bart |
| Ermes Blarasin als Bloated Woman |
 | Sanjay Talwar als Doctor Rosen |
 | Kim Roberts als Cora |
 | Tim Post als Reviving Doctor |
 | Matt Sadowski-Austin als EMS Technician |
 | Philip DeWilde als EMS Technician |
| David Campbel als Squished Zombie |
 | Phillip MacKenzie als Thrashing Zombie |
| Neville Edwards als CDC Spokesperson |
| Sandy Jobin-Bevans als CDC Reporter |
 | Natalie Brown als CDC Reporter |
 | Liz West als CDC Reporter |
| Blu als Chips |
 | Scott H. Reiniger als The General |
 | Tom Savini als The County Sheriff |
 | Ken Foree als The Televangelist |
| Kim Kerns als Girl on Steve's Boat in the Video (uncredited) |
 | Zack Snyder als Commando at White House (uncredited) |
| Taso N. Stavrakis als Car Driver (uncredited) |
 | Rorelee Tio als Bus Passenger (uncredited) |
 | Malcolm Scott als Bus Passenger (uncredited) |
 | Ioan Gruffudd als Soldier on Camera (uncredited) |
 | John Migliore als Zombie (uncredited) |
| Darren Marsman als Maintenance Man Zombie (uncredited) |
 | Cam Clarke als (voice, uncredited) |
| Zack Snyder | Director |
| James Gunn | Screenplay |
| Marc Abraham | Producer |
| Eric Newman | Producer |
| Richard P. Rubinstein | Producer |
| Tyler Bates | Original Music Composer |
| Matthew F. Leonetti | Director of Photography |
| Niven Howie | Editor |
| Joseph Middleton | Casting |
| Andrew Neskoromny | Production Design |
| Arvinder Greywal | Art Direction |
| Steve Shewchuk | Set Decoration |
| Denise Cronenberg | Costume Design |
| Darrell Hall | Music Editor |
| Scott A. Hecker | Supervising Sound Editor |
| Gary D'Amico | Special Effects |
| John Stoneham Jr. | Stunt Coordinator |
| Nick Alachiotis | Stunts |
| Brittney Banks | Utility Stunts |
| Jordana Lieberman | Assistant Director |
| Armyan Bernstein | Executive Producer |
| Thomas A. Bliss | Executive Producer |
| Dennis E. Jones | Executive Producer |
| Michael D. Messina | Co-Producer |
| Dug Rotstein | Script Supervisor |
| Michael Carella | Camera Operator |
| Gilles Corbeil | Steadicam Operator |
| Russ Goozee | Camera Operator |
| Jason Leib | Post Production Supervisor |
| Janine Anderton | Production Coordinator |
| G. Marq Roswell | Music Supervisor |
| John J. Thomson | Production Sound Mixer |
| Frederick Howard | Sound Effects Editor |
| Frank Alexander | Costume Supervisor |
| Natalie Bronfman | Assistant Costume Designer |
| Mario Cacioppo | Makeup Department Head |
| Diana Ladyshewsky | Hair Department Head |
| Carol Hartwick | Key Hair Stylist |
| RaMona Fleetwood | Hairstylist |
| Damon Caro | Stunt Coordinator |
| Rob Ballantyne | Assistant Art Director |
| Dennis Berardi | Visual Effects Supervisor |
| Eric J. Robertson | Visual Effects Producer |
| James Halpenny | Construction Coordinator |
| Kim Karon | Set Designer |
| Chuck Courrieu | Additional Photography |
| Christopher Raucamp | First Assistant Camera |
| Jasmina Vasileva | Set Costumer |
| Shawney Cohen | CG Supervisor |
| J.P. O'Donnell | Craft Service |
| Jennifer Mccormack | Driver |
| Nicole Michaud | Makeup Effects |
| Jeff Schweikart | Post Production Assistant |
| Steve Holt | Set Medic |
| Terrence B. Zinn | Set Production Assistant |
| Laird McMurray | Special Effects Coordinator |
| Mark Chong | Technical Supervisor |
| Dana Howes | Transportation Coordinator |
| Jeffrey Cassidy | Video Assist Operator |
| Sharon Smith Holley | Visual Effects Editor |
| Melissa Remenarich | First Assistant Editor |
| Michael Galbraith | Gaffer |
| Philip Esteves | Lighting Technician |
| Tom Starnes | Rigging Gaffer |
| Lauren Grey | Casting Associate |
| Marty Dejczak | Location Manager |
| Terry Edinger | Production Accountant |
| Stephanie Keating | Publicist |
| Alan Zielonko | Boom Operator |
| Carmen Flores De Tanis | First Assistant Sound Editor |
| Gary A. Hecker | Foley |
| Tom Calderaro | Orchestrator |
| Jay Wilkinson | Sound Editor |
| Chris Jenkins | Sound mixer |
| Suzanne Hodson | Set Decoration Buyer |
| Brent Robinson | Underwater Camera |
| Barney Burman | Prosthetic Supervisor |
| Damon Caro | Choreographer |
| Vladimir Popovic | Systems Administrators & Support |
| John 'Frenchie' Berger | Armorer |
| Richard Kroll | Researcher |
| Aaron Weintraub | Visual Effects |
| Arthur Langevin | Pyrotechnic Supervisor |
| Michael MacDonald | Unit Production Manager |
| Mike Kirilenko | Key Grip |
| Jo-Ann MacNeil | Key Makeup Artist |
| Michael Huschka | Assistant Property Master |
| J. Tracy Budd | Set Dresser |
| Kyle Cooper | Title Designer |
| Ron Renzetti | Dolly Grip |
| William Engel | Grip |
| Wynona Price | Makeup Artist |
| Troy Waters | Marine Coordinator |
| Dave Tommasini | Pilot |
| Peter D. Marshall | First Assistant Director |
| Eric S. Potechin | Second Assistant Director |
| Joel Hay | Third Assistant Director |
| Gary Burritt | Negative Cutter |
| Caitlin McKenna | ADR Voice Casting |
| Sandra Lynne Hyhkö | Assistant Production Coordinator |
| Sara Kay | Casting Assistant |
| Evan T. Chen | ADR Editor |
| Andrew Bock | Assistant Sound Editor |
| Pete Anthony | Conductor |
| Michael Dressel | Foley Editor |
| Derek Leininger | Musician |
| Hoa Tran | 3D Animator |
| Brian Anderson | 3D Artist |
| Patrick Coffey | Visual Effects Designer |
| David Scott | Prosthetic Makeup Artist |
| Frank Fleming | Sound Recordist |
| Ron Hewitt | Property Master |
| Benjamin Beardwood | Dialogue Editor |
| Allen Hartz | Dialogue Editor |
| Byron Wilson | ADR Supervisor |
| Tree Adams | Additional Music |
| Scoot DeVille | Assistant Makeup Artist |
| Pamela Hackwell | Contact Lens Technician |
| Clay Staub | Second Unit Director |
| Jordu Schell | Concept Artist |
| David Best | Graphic Designer |
| Rob Bonney | Head Carpenter |
| Patricia Cowmeadow | Set Supervisor |
| Vince Peets | Storyboard Artist |
| Jeff Gomillion | ADR Mixer |
| Alfonso Calvo | ADR Recordist |
| Tony Acosta Jr. | Special Effects Technician |
| Scott Alan Cook | Stunt Double |
| Murat Akser | Assistant Camera |
| Mark Beauchamp | Second Assistant Camera |
| Brian Anderson | Senior Animator |
| David McGroarty | Assistant Editor |
| Michael Eaves | Color Timer |
| Michael Eaves | Digital Color Timer |
| Curtis Lindersmith | Digital Intermediate Editor |
| Scott Alexander | Assistant Location Manager |
| Brett Miller | Location Production Assistant |
| Terri Greening | Accountant |
| Andreas Hass | Assistant Production Coordinator |
| Humberto Zamorate | CG Artist |
| Barb Benoit | Digital Compositor |
| Chad Darnell | Extras Casting |
| Sara Holmes | First Assistant Accountant |
| Gary Kleinsteuber | Key Special Effects |
| Alex Kontsalakis | Payroll Accountant |
| Lillian Awa | Production Assistant |
| Douglas Thompson | Production Secretary |
| Sarah McIntosh | Second Assistant Accountant |
| George A. Romero | Original Film Writer |
| Brad Martin | Stunts |
| Taso N. Stavrakis | Stunt Driver |
| Deborah Rutherford | Prosthetic Makeup Artist |
| Alison Reid | Stunts |
| Shelley Cook | Stunts |
| Lauro Chartrand | Stunts |
| Scott Reitz | Technical Advisor |
