 | Chris Pratt als Emmet Brickowski / Rex Dangervest (voice) |
 | Elizabeth Banks als Wyldstyle / Lucy (voice) |
 | Will Arnett als Batman (voice) |
 | Tiffany Haddish als Queen Watevra Wa'Nabi (voice) |
 | Stephanie Beatriz als General Mayhem / Sweet Mayhem (voice) |
 | Alison Brie als Unikitty / Ultrakatty (voice) |
 | Nick Offerman als MetalBeard (voice) |
 | Charlie Day als Benny (voice) |
 | Maya Rudolph als Mom |
 | Will Ferrell als President Business / Dad |
 | Jadon Sand als Finn |
 | Brooklynn Prince als Bianca |
 | Channing Tatum als Superman (voice) |
 | Jonah Hill als Green Lantern (voice) |
 | Richard Ayoade als Ice Cream Cone (voice) |
 | Ben Schwartz als Banarnar (voice) |
 | Noel Fielding als Balthazar (voice) |
 | Jason Momoa als Aquaman (voice) |
 | Cobie Smulders als Wonder Woman (voice) |
 | Ike Barinholtz als Lex Luthor (voice) |
 | Ralph Fiennes als Alfred Pennyworth (voice) |
 | Will Forte als Abraham Lincoln (voice) |
 | Jimmy O. Yang als Enthusiastic Zebra (voice) |
 | Jorma Taccone als Larry Poppins (voice) |
 | Bruce Willis als Bruce Willis (voice) |
 | Gary Payton als Gary Payton (voice) |
 | Sheryl Swoopes als Sheryl Swoopes (voice) |
| Todd Hansen als Gandalf / Swamp Creature (voice) |
| Doug Nicholas als Surfer Dave / Chainsaw Dave / Purgatory Dave (voice) |
 | Liam Knight als Duplo / Heart / Star / Sewer Babies (voice) |
| Emmett Mitchell als Duplo / Duplo Foreman / Duplo Wonder Woman (voice) |
 | Sawyer D. Jones als Duplo / Heart / Star (voice) |
| Graham Miller als Duplo / Young Finn |
| Cora Miller als Duplo / Star (voice) |
| Ollie Mitchell als Duplo (voice) |
 | Mike Mitchell als Various Characters (voice) |
 | Christopher Miller als Horse / Chocolate Bar / Plantimals / Paper Boy / Chad (voice) |
 | Margot Rubin als Various Characters (voice) |
| Emily Nordwind als Cleopatra (voice) |
 | Chris McKay als Larry the Barista (voice) |
 | Trisha Gum als Velma (voice) |
| Ryan Halprin als Dolphin Clock / Apocalypseburg Citizen (voice) |
 | Lauren White als Apocalypseburg Citizen (voice) |
| Bob Kane | Characters |
| Mark Mothersbaugh | Original Music Composer |
| Michael Uslan | Executive Producer |
| Mary Hidalgo | Casting |
| Luke Emrose | Visual Effects |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| Roy Lee | Producer |
| Greg Silverman | Production Executive |
| Nicholas Stoller | Creative Consultant |
| Glenn Ficarra | Creative Consultant |
| John Requa | Creative Consultant |
| Clare Knight | Editor |
| Mike Mitchell | Director |
| Dan Lin | Producer |
| Christopher DeFaria | Production Executive |
| Jinko Gotoh | Producer |
| Jared Stern | Creative Consultant |
| Phil Lord | Screenplay |
| Phil Lord | Producer |
| Phil Lord | Story |
| Jill Wilfert | Executive Producer |
| Chris McKay | Executive Producer |
| Christopher Miller | Screenplay |
| Christopher Miller | Producer |
| Christopher Miller | Story |
| Bill Finger | Characters |
| Zareh Nalbandian | Executive Producer |
| Jon Burton | Co-Producer |
| Stacy Ekstein | Line Producer |
| William Moulton Marston | Characters |
| Jon Lajoie | Songs |
| Keith Malone | Executive Producer |
| Caroline Cranstoun | Costume Design |
| Craig Berry | Head of Story |
| Erik Aadahl | Supervising Sound Editor |
| Naomi Bakstad | Key Makeup Artist |
| Heiko von Drengenberg | Animation |
| Kristen Anderson | Art Direction |
| Nick Dudar | Art Direction |
| Timothy Jason Smith | Associate Producer |
| Anne Carroll | Key Hair Stylist |
| Trisha Gum | Animation Director |
| Kier Lehman | Music Supervisor |
| Jorjee Douglass | Makeup Artist |
| Yeva McCloskey | Art Direction |
| Ryan Halprin | Executive Producer |
| Michelle Morgan | Creative Consultant |
| Will Allegra | Executive Producer |
| Matthew Ashton | Executive Producer |
| Courtenay Valenti | Production Executive |
| Emma Marie DuPell | Assistant Editor |
| Sharon Taylor | Co-Producer |
| Sharon Taylor | General Manager |
| Sebastian Ampuero | Visual Effects |
| Elana Andersen | Visual Effects |
| Garry Baker | Visual Effects |
| James Bishop | Visual Effects |
| Rosalynd Clarke | Visual Effects |
| Drew Collins | Visual Effects |
| Shane Goddard | Visual Effects |
| Samson Heffernan | Visual Effects |
| Steven Lees-Smith | Visual Effects |
| Josh Lewis | Visual Effects |
| Daniel Lopez | Visual Effects |
| Patrick Madden | Visual Effects |
| Kevin Ng | Visual Effects |
| Eugene Purugganan | Visual Effects |
| Shayne Rodway | Visual Effects |
| Grant Street | Visual Effects |
| César Sáez | Visual Effects |
| Mark Theriault | Visual Effects |
| Radu Vintila | Visual Effects |
| Jeremy Webber | Visual Effects |
| Daniel Powter | Visual Effects |
| Emily Dean | Animation |
| Nathan Fitzgerald | Animation |
| Sasha Schotzko-Harris | Animation |
| Megan Harkness | Makeup Artist |
| Matthew Fogel | Story |
| Patrick Marc Hanenberger | Production Design |
| Kristen Murtha | Co-Producer |
| David Burgess | Animation Supervisor |
| Lilia Afsahi | Hairstylist |
| Rebecca Karch Tomlinson | Associate Producer |
| Margot Rubin | Recording Supervision |
| Joe Kucharski | Costume Design |
| Alan Tyler | Scoring Mixer |
| Alan Tyler | Additional Music |
| Chris Leahy | Executive Producer |
| Leah Stipic | Assistant Editor |
