 | Johnny Depp als William Blake |
 | Gary Farmer als Nobody |
 | Crispin Glover als Train Fireman |
 | Lance Henriksen als Cole Wilson |
 | Michael Wincott als Conway Twill |
 | Eugene Byrd als Johnny 'The Kid' Pickett |
 | John Hurt als John Scholfield |
 | Robert Mitchum als John Dickinson |
 | Iggy Pop als Salvatore 'Sally' Jenko |
 | Gabriel Byrne als Charlie Dickinson |
 | Jared Harris als Benmont Tench |
 | Mili Avital als Thel Russell |
 | Jimmie Ray Weeks als Marvin, Older Marshal |
 | Mark Bringelson als Lee, Younger Marshal |
 | John North als Mr. Olafsen |
 | Alfred Molina als Trading Post Missionary |
 | Billy Bob Thornton als Big George Drakoulious |
 | Michelle Thrush als Nobody's Girlfriend |
 | Steve Buscemi als Bartender |
 | Gibby Haynes als Man with Gun in Alley |
 | Richard Boes als Man with Wrench |
| Jim Jarmusch | Director |
| Jim Jarmusch | Screenplay |
| Demetra J. MacBride | Producer |
| Neil Young | Original Music Composer |
| Robby Müller | Director of Photography |
| Jay Rabinowitz | Editor |
| Ellen Lewis | Casting |
| Laura Rosenthal | Casting |
| Bob Ziembicki | Production Design |
| Ted Berner | Art Direction |
| Dayna Lee | Set Decoration |
| Marit Allen | Costume Design |
| Robert Hein | Supervising Sound Editor |
| Magdaline Volaitis | Sound Effects Editor |
| Lou Carlucci | Special Effects Coordinator |
| Randall Balsmeyer | Visual Effects Supervisor |
| Jon Farhat | Visual Effects Supervisor |
| Al Jones | Stunt Coordinator |
| Erik Stabenau | Stunts |
| Karen Koch | Co-Producer |
| Patty York | Makeup Artist |
| Eugene Gearty | Sound Effects Editor |
| Drew Kunin | Sound Mixer |
| Richard Alonzo | Prosthetic Makeup Artist |
| Clare M. Corsick | Hairstylist |
| David Dupuis | Prosthetics |
| Scott W. Farley | Key Hair Stylist |
| Tom Irvin | Special Effects Makeup Artist |
| Todd Kleitsch | Assistant Makeup Artist |
| Leon Laderach | Prosthetics |
| Neal Martz | Key Makeup Artist |
| Joel Harlow | Special Effects Makeup Artist |
| Christopher Allen Nelson | Special Effects Makeup Artist |
| Beth DePatie | Production Manager |
| Jude Gorjanc | Second Assistant Director |
| Constance L. Hoy | Second Second Assistant Director |
| Todd Pfeiffer | First Assistant Director |
| Cheyenne Ali | Scenic Artist |
| Arthur Allyn | Construction Foreman |
| Mark Balda | Carpenter |
| Elizabeth A. Beckman | Art Department Coordinator |
| Michael Bennett | Greensman |
| Michael Blair | Carpenter |
| Mark Borg | Carpenter |
| Karen M. Clark | Swing |
| Edie Douglass | Assistant Property Master |
| George A. Fleming | Scenic Artist |
| John A. Foote | Swing |
| Tony Gibson | Swing |
| Bill Holmquist | Construction Coordinator |
| Kevin Hughes | On Set Dresser |
| Terry Kempf | Head Carpenter |
| Richard Lambert | Leadman |
| Suzanne Lapick | Assistant Property Master |
| Walt Mikolwski | Carpenter |
| Craig Anthony Muzio | Scenic Artist |
| Jack Orlando | Carpenter |
| John Pattison | Property Master |
| Kenneth Stellar | Greensman |
| James Stephenson | Carpenter |
| Kenneth Sylvester | Scenic Artist |
| Mae Brunken | Set Designer |
| Shari Hilliard | Art Department Production Assistant |
| Brick Mason | Storyboard Artist |
| Stephen M. Vernarelli | Set Designer |
| Coll Anderson | Sound Recordist |
| Kam Chan | Foley Editor |
| Héctor Cordero | Sound Re-Recording Mixer |
| Marko Costanzo | Foley Artist |
| Keith Culbertson | Sound Re-Recording Mixer |
| Dan Evans Farkas | Assistant Sound Editor |
| Mark Goodermote | Boom Operator |
| Hextro | Sound Re-Recording Mixer |
| Frank Kern | Foley Editor |
| Julie Lindner | Assistant Sound Editor |
| Kimberly R. McCord-Wilson | Apprentice Sound Editor |
| Sylvia Menno | Dialogue Editor |
| Bruce Pross | Foley Supervisor |
| Stacey Tanner | Sound Recordist |
| Mark DeSimone | ADR Mixer |
| John C. Carlucci | Special Effects Assistant |
| Joe Fordham | Special Effects Coordinator |
| Mark Habegger | Special Effects Manager |
| Nori Honda | Special Effects Makeup Artist |
| Joe Garert | Compositing Artist |
| Anne Putnam Kolbe | Visual Effects Coordinator |
| Daniel Leung | Digital Compositor |
| Steven T Puri | Visual Effects Producer |
| Ken Smith | Compositing Artist |
| Mimi Abers | Digital Compositor |
| Marc Rubone | Rotoscoping Artist |
| Marc Rubone | Animation |
| Tori Bridges | Stunts |
| James Brisbin | Electrician |
| Eric Budlong | Grip |
| Kenny Davis | Dolly Grip |
| Robert K. Feldmann | Key Grip |
| Lisa K. Ferguson | Second Assistant Camera |
| Kirk R. Gardner | Steadicam Operator |
| Bob Gorelick | Steadicam Operator |
| Todd Heater | Electrician |
| Jon Hokanson | Electrician |
| Chris Lombardi | Second Unit Director of Photography |
| David Luckenbach | Steadicam Operator |
| Jeff Mart | Steadicam Operator |
| Byron McCulloch | Best Boy Grip |
| Michael Palmer | Best Boy Electric |
| Christine Parry | Still Photographer |
| Tony J. Pirri | Grip |
| Christopher Porter | Gaffer |
| Bobby L. Smith | Grip |
| Pim Tjujerman | First Assistant Camera |
