 | Ryan Reynolds als Wade Wilson / Deadpool |
 | Hugh Jackman als Logan / Wolverine |
 | Emma Corrin |
 | Morena Baccarin als Vanessa Carlysle |
 | Rob Delaney als Peter |
 | Leslie Uggams als Blind Al |
 | Karan Soni als Dopinder |
 | Matthew Macfadyen als Paradox |
 | Stefan Kapičić als Piotr Rasputin / Colossus (voice) |
 | Brianna Hildebrand als Ellie Phimister / Negasonic Teenage Warhead |
 | Shioli Kutsuna als Yukio / Pinkie Pie |
 | Lewis Tan als Gaveedra-Seven / Shatterstar |
 | Randal Reeder als Buck |
 | Aaron Stanford als John Allerdyce / Pyro |
 | Jennifer Garner als Elektra Natchios |
 | Chris Hemsworth als Thor Odinson (archive footage) |
| Rob Liefeld | Characters |
| Fabian Nicieza | Characters |
| Kevin Feige | Producer |
| Shawn Levy | Director |
| Rhett Reese | Writer |
| Paul Wernick | Writer |
| Louis D'Esposito | Executive Producer |
| Ryan Reynolds | Producer |
| Ryan Reynolds | Writer |
| Shawn Levy | Producer |
| Zeb Wells | Writer |
| Sarah Halley Finn | Casting |
| Shawn Levy | Writer |
| George Richmond | Director of Photography |
| Ray Chan | Production Design |
| Mayes C. Rubeo | Costume Design |
| George Cottle | Second Unit Director |
| Rob Simonsen | Original Music Composer |
| Mitchell Bell | Co-Producer |
| Naomi Moore | Set Decoration |
| Dave Jordan | Music Supervisor |
| Shane Reid | Editor |
| Lauren Shuler Donner | Producer |
| Wendy Jacobson | Executive Producer |
| Mary McLaglen | Executive Producer |
| Josh McLaglen | Executive Producer |
| Rhett Reese | Executive Producer |
| Paul Wernick | Executive Producer |
| George Dewey | Executive Producer |
| Simon Kinberg | Executive Producer |
| Jonathon Komack Martin | Executive Producer |
| Swen Gillberg | Visual Effects Supervisor |
| Dean Zimmerman | Editor |
| Erin E. Riegel | Art Direction |
| George Cottle | Stunt Coordinator |
