 | Luke Goss als Carl 'Luke' Lucas / Frankenstein |
 | Ving Rhames als Weyland |
 | Danny Trejo als Goldberg |
 | Tanit Phoenix als Katrina Banks |
 | Dougray Scott als Niles York |
 | Robin Shou als 14K |
 | Langley Kirkwood als Dr. Klein |
 | Frederick Koehler als Lists |
 | Tanya van Graan als Amber |
 | Sean Cameron Michael als New Doctor |
 | Hlubi Mboya als Satana |
 | Charlbi Dean als Calimity J |
 | Mark Elderkin als Sgt. Fury |
 | Eugene Khumbanyiwa als Nero |
 | Jeremy Crutchley als Psycho |
 | Yrsa Daley-Ward als Salinas |
 | Ebby Weyime als Maria Rodriguez |
 | Kim Suzanne Engelbrecht als Kelly O' Donnell |
 | Roxane Hayward als Prudence |
 | Bart Fouche als Razor |
 | Michelle van Schaik als Olga Braun |
 | Jesselyn Abrahamse als Silky |
 | Roxane Van Rooyen als Elsa |
| Shaamilla Noordien als Corns |
 | Gina Athans als Ali |
 | Simone Van Rooyen als Alva Twin |
 | Kim Syster als Olivia |
 | Sylvia Mngxekeza als KP Goldberg Fan Guard |
 | Peter Butler als Executive |
 | Natalie Becker als Pretty Reporter |
 | Quentin Chong als Triad Driver |
 | Irina Miccoli als Weyland's Assistant |
| Chase Armitage als Apache (archive footage) |
| Roel Reiné | Director |
| Tony Giglio | Screenplay |
| Patrick O'Connor | Art Direction |
| Mike Elliott | Producer |
| Radu Ion | Editor |
| Gary Oldroyd | Visual Effects Supervisor |
| Abigail Metcalfe | Costume Supervisor |
| Paul W. S. Anderson | Producer |
| Michael Trent | Editor |
| Mark Walker | Art Direction |
| Sarel Pretorius | Steadicam Operator |
| Trevor Morris | Music |
| Bonnie Lee Bouman | Casting |
| David Bloomer | Still Photographer |
| Jonathan Wales | Sound Re-Recording Mixer |
| Grant Hulley | Stunt Coordinator |
| Gillian Hawser | Casting |
| Jan Glaser | Casting |
| Ria van Heerden | Script Supervisor |
| Chris Diebold | Sound Effects Editor |
| Mito Skellern | Casting |
| Gillian Florence | Costume Supervisor |
| Jeremy Bolt | Producer |
| Andrew McCarthy | Set Decoration |
| Jonathan Miller | Supervising Sound Editor |
| Paul W. S. Anderson | Story |
| Roel Reiné | Camera Operator |
| Tony Giglio | Story |
| Andrew Orlando | Production Design |
| Cordell McQueen | Special Effects Supervisor |
| Kerry Skelton | Makeup Designer |
| Clinton Smith | Prosthetic Supervisor |
| Cordell McQueen | Stunts |
| Jared Cohen | Stunts |
| Tertius De Lange | Stunts |
| Malcolm Cochrane | Stunts |
| Erik Cord | Stunts |
| Greg Holstein | Associate Producer |
| Alan Shearer | Line Producer |
| Marvin Saven | Co-Producer |
| Roger Corman | Executive Producer |
| Roel Reiné | Director of Photography |
| Wayne Shields | Director of Photography |
| Amanda Ross-McDonald | Key Makeup Artist |
| Danielle Knox | Costume Design |
| Lian van Wyk | Makeup Artist |
| Michelle Karavoussanos | Assistant Costume Designer |
| Mandy Smit | Key Set Costumer |
| Jaci Cheiman | Casting Coordinator |
| Moray McGregor | Assistant Property Master |
| Bruce Dalgleish | Carpenter |
| Sadam Folokwe | Carpenter |
| Nicolus Lusse | Carpenter |
| Kate Hilson | Graphic Designer |
| Arlo Markantonatos | Property Master |
| Jo Stuart Fox | Set Dresser |
| Gabriel Williams | First Assistant Director |
| Lynne-Anne Vosloo | Second Assistant Director |
| Johan Horjus | Camera Operator |
| Ashlea Tamara Downes | Camera Trainee |
| Quinton Fredricks | Camera Trainee |
| Margaret Muggleston | Camera Loader |
| Jacques van Tonder | Digital Imaging Technician |
| Neil Baillie | First Assistant "A" Camera |
| Zane Harrison | First Assistant "B" Camera |
| Justin Paterson | Gaffer |
| Jens Bacher | Key Grip |
| Keith Saayman | Libra Head Technician |
| Diogo Domingues | Second Assistant Camera |
| Nigel Tompkins | Second Assistant Camera |
| Stephen Webster | ADR Mixer |
| James Hyde | ADR Recordist |
| Ryan Briley | Assistant Sound Editor |
| Derek Mansvelt | Production Sound Mixer |
| Laszlo Mates | Visual Effects Supervisor |
| Cordell McQueen | Pyrotechnician |
| Julio Scholze | Special Effects Technician |
| Emil Snyman | Special Effects Technician |
| Calen Van Schalkwyk | Special Effects Technician |
| Robbie Renfrow | Additional Colorist |
| Leandro Marini | Digital Intermediate Colorist |
| Ryan Gee | Digital Intermediate Editor |
| Rain Valdez | Digital Intermediate Producer |
| Ruben Sebban | First Assistant Editor |
| Shie Rozow | Music Editor |
| Shawn Campbell | Armorer |
| Ted Liebenberg | Armorer |
| Valdor Uren | Armorer |
| Gert Uys | Pilot |
| Billi Bruins | Production Accountant |
| Amy Lyons | Production Assistant |
| Jade Hamilton | Production Coordinator |
| Jahan Lopes | Researcher |
| Andrew Strachan | Production Manager |
