 | Reese Witherspoon als Pam Hobbs |
 | Colin Firth als Ron Lax |
 | Alessandro Nivola als Terry Hobbs |
 | James Hamrick als Damien Echols |
 | Seth Meriwether als Jason Baldwin |
 | Kristopher Higgins als Jessie Misskelley |
 | Amy Ryan als Margaret Lax |
 | Kevin Durand als John Mark Byers |
 | Bruce Greenwood als Judge David Burnett |
 | Stephen Moyer als John Fogelman |
 | Elias Koteas als Jerry Driver |
 | Martin Henderson als Brent Davis |
 | Rex Linn als Chief Inspector Gitchell |
 | Collette Wolfe als Glori Shettles |
 | Dane DeHaan als Chris Morgan |
 | Mireille Enos als Vicki Hutcherson |
 | Haley Craft als Teenage Employee |
 | Julie Ivey als Melissa Byers |
 | Kate Kneeland als Ron's Secretary |
 | Kerry Cahill als Jo Lynn |
 | Bill Murphey als Marty King |
 | Lindsey Moser als Teacher at Weaver |
 | Kristoffer Polaha als Val Price |
 | Matt Letscher als Paul Ford |
 | Michael Gladis als Dan Stidham |
 | Ted Huckabee als Steve Jones |
 | Jet Jurgensmeyer als Stevie Branch |
 | Brandon Spink als Chris Byers |
 | Jack Coghlan als Aaron Hutcheson |
 | Lori Beth Sikes als Annie |
 | Gary Grubbs als Dale Griffis |
| Stan Houston als Detective Donald Bray |
| Matthew Stanton als Detective Durham |
 | Brian Howe als Detective McDonough |
 | Brooke Jaye Taylor als Officer Regina Meeks |
| Atom Egoyan | Director |
| Paul Harris Boardman | Producer |
| Clark Peterson | Producer |
| Richard Saperstein | Producer |
| Scott Derrickson | Screenplay |
| Elizabeth Fowler | Producer |
| Paul Harris Boardman | Screenplay |
| Christopher Woodrow | Producer |
| Susan Shipton | Editor |
| Thomas Minton | Art Direction |
| Phillip Barker | Production Design |
| Mara Leveritt | Novel |
| Paul Sarossy | Director of Photography |
| Mychael Danna | Original Music Composer |
| Ashley Patterson | Script Supervisor |
| Jennifer L. Smith | Casting |
| Kari Perkins | Costume Design |
| Tricia Wood | Casting |
| Deborah Aquila | Casting |
| Jessie Misskelley, Jr. | Executive Producer |
| Sarah E. Johnson | Executive Producer |
| Molly Conners | Executive Producer |
| Maria Cestone | Executive Producer |
| Mara Leveritt | Executive Producer |
| Hoyt David Morgan | Executive Producer |
| Jacob Pechenik | Executive Producer |
| Scott Derrickson | Executive Producer |
| David Alper | Executive Producer |
| Michael Flynn | Executive Producer |
| Jason Baldwin | Executive Producer |
| Michael Flynn | Unit Production Manager |
| Walter Gasparovic | First Assistant Director |
| Kristina M. Peterson | Second Assistant Director |
| Laura Katz | Music Supervisor |
| Steve Munro | Sound Designer |
| Day Permuy | Production Supervisor |
| Cody Williams | Second Second Assistant Director |
| Marc Dobiecki | Camera Operator |
| Ian Forsyth | Steadicam Operator |
| Lee Blasingame | First Assistant Camera |
| Jonathan Carbonaro | Digital Imaging Technician |
| Tina Rowden | Still Photographer |
| Becky Campbell | Production Coordinator |
| Elizabeth Himelstein | Dialect Coach |
| Melinda Sanders | Set Decoration |
| Kimberly Jones | Makeup Department Head |
| Joani Yarbrough | Hair Department Head |
| Teresa Foshee | Key Makeup Artist |
| Monty Schuth | Key Hair Stylist |
| Shirley Libby | Sound Mixer |
| Freddy Chancellor | Boom Operator |
| James Peterson | Utility Sound |
| Denny Mooradian | Gaffer |
| Chris Birdsong | Key Grip |
| Norman Bielowicz | Location Manager |
| Carl Johnson | Rigging Gaffer |
