 | Danny DeVito als Chief Wyatt Rash |
 | Bette Midler als Mona Dearly |
 | Neve Campbell als Ellen Rash |
 | Jamie Lee Curtis als Rona Mace |
 | Casey Affleck als Bobby Calzone |
 | William Fichtner als Phil Dearly |
 | Marcus Thomas als Jeff Dearly |
 | Peter Dobson als Lt. Feege Gruber |
 | Kathleen Wilhoite als Lucinda |
 | Tracey Walter als Clarence |
 | Will Ferrell als Cubby |
 | Paul Ben-Victor als Deputy Tony Carlucci |
 | Paul Schulze als Deputy Jimmy D. |
 | Mark Pellegrino als Murph Calzone |
 | Raymond O'Connor als Father Tom Stowick |
 | Lisa Rieffel als Valerie |
 | Robert Arce als Doctor Schwartz |
 | Brittany Peterson als Maria Lasala |
| Philip Perlman als Charm Motel Cashier |
 | Melissa McCarthy als Shirley |
| Jason Monkarsh als Benny |
 | Brian Doyle-Murray als Tow Truck Driver |
 | Yul Vazquez als French Instructor |
 | Danielle Camastra als White Trash Golfer (uncredited) |
| Nick Gomez | Director |
| Peter Steinfeld | Writer |
| Michael Tavera | Original Music Composer |
| Bruce Douglas Johnson | Director of Photography |
| Richard Pearson | Editor |
| Monika Mikkelsen | Casting |
| Richard Toyon | Production Design |
| Karen Agresti | Set Decoration |
| Terry Dresbach | Costume Design |
| Bart Rosenblatt | Producer |
| Eugene Musso | Producer |
| Danny DeVito | Executive Producer |
| Michael Shamberg | Executive Producer |
| Stacey Sher | Executive Producer |
| Jonathan Weisgal | Executive Producer |
| Al Corley | Producer |
| Mark Weingarten | Production Sound Mixer |
| Cindy Folkerson | Stunt Coordinator |
| Jeff Smolek | Stunt Double |
| Douglas Jones | Production Supervisor |
| Patti Dalzell | Script Supervisor |
| Jimmy Holcomb | Production Coordinator |
| Erin Borel | Assistant Production Coordinator |
| Stacey Holmes | Second Second Assistant Director |
| Bart Rosenblatt | Production Manager |
| John M. Nelson | First Assistant Director |
| Wendi Lampassi | Second Assistant Director |
| William Webb | "A" Camera Operator |
| William Webb | Steadicam Operator |
| Nya Patrinos | Leadman |
| Betty Krul | Set Designer |
| Andrea Dietrich | Storyboard Artist |
| Lawrence L. Commans | Boom Operator |
| Scott Buckwald | Property Master |
| Steve Belsky | Gaffer |
| David A. Santos | Key Grip |
| Rocky Ford | Best Boy Grip |
| George Herthel | Location Manager |
| Pie Lombardi | Wardrobe Supervisor |
| Bega Metzner | Key Costumer |
| Carol Strong | Makeup Department Head |
| Angela Johnson | Makeup Artist |
| Denise Pugh-Ruiz | Makeup Artist |
| Audrey Futterman-Stern | Hair Department Head |
| Marsha L. Swinton | Production Accountant |
| Michael Klastorin | Unit Publicist |
| Peter Sorel | Still Photographer |
| Mylan Stepanovich | Payroll Accountant |
| Spike Allison Hooper | Post Production Supervisor |
| John Hartigan | Special Effects |
| David Waine | Special Effects Coordinator |
| Jeff Kushner | Associate Editor |
| Jeff Kushner | Supervising Sound Editor |
| Jeff Kushner | Sound Designer |
| Christopher Flick | Foley Editor |
| Donald Flick | Sound Effects Editor |
| Evan T. Chen | Sound Effects Editor |
| Mary Ruth Smith | ADR Supervisor |
| David E. Stone | Dialogue Editor |
| Mary Andrews | Dialogue Editor |
| Ryan Murphy | Sound Recordist |
| Patrick Giraudi | Additional Sound Re-Recording Mixer |
| Jeffrey Perkins | Sound Re-Recording Mixer |
| Samuel Lehmer | Sound Re-Recording Mixer |
| Ken Dufva | Foley Artist |
| David Lee Fein | Foley Artist |
| Marty Church | Foley Recordist |
| Mark McBryde | ADR Mixer |
| Jamie Baker | ADR Mixer |
| Terry Delsing | Music Editor |
| Bunny Andrews | Music Editor |
| Bryan Pennington | Dolby Consultant |
| Bruce Douglas Johnson | Visual Effects Supervisor |
| Adam Stern | Rotoscoping Artist |
| Michael Adkisson | Compositing Supervisor |
| John W. Barbee | Transportation Coordinator |
| Jimmie K. Turner | Transportation Captain |
| Leah Buono | Casting Assistant |
| David Falicki | Set Medic |
| Jim Hartz | Studio Teacher |
| Wendy Wilhite Chatley | Studio Teacher |
| Maura Gannett | Studio Teacher |
| Robert Easton | Dialect Coach |
| Mo Henry | Negative Cutter |
| Scott Cochran | Scoring Mixer |
| Dane Farwell | Stunt Double |
| Thomas Opitz | Key Hair Stylist |
| Thomas R. Burman | Special Effects Makeup Artist |
| Bari Dreiband-Burman | Special Effects Makeup Artist |
| Randall Huber | Stunt Double |
| Kent W. Luttrell | Stunt Double |
| Brian J. Williams | Stunt Double |
| Brian Maynard | Stunt Driver |
| Cindy Folkerson | Stunt Double |
| Bengt Jonsson | Second Unit Director of Photography |
