 | Dakota Fanning als Euphemia 'Effie' Gray |
 | Emma Thompson als Lady Eastlake |
 | Greg Wise als John Ruskin |
 | Tom Sturridge als Everett Millais |
 | Robbie Coltrane als Doctor |
 | Julie Walters als Margaret Cox Ruskin |
 | Derek Jacobi als Travers Twiss |
 | Claudia Cardinale als Viscountess |
 | David Suchet als Mr. Ruskin |
 | James Fox als Sir Charles Eastlake |
 | Patrick Doyle als Wedding Minister |
 | Russell Tovey als George |
 | Linda Bassett als Anna |
 | Pip Torrens als Royal Academy / Times Journalist |
 | Nicholas Jones als Doctor Lee |
 | Joanna Hole als Mrs. McPhail (uncredited) |
 | Riccardo Scamarcio als Rafael |
| Polly Dartford als Sophie Gray |
| Tom Herriott als William Holman Hunt |
| Sam Churchill als Dante Gabriel Rossetti |
| Martin Keatman als Thomas Woolner |
| Chris Haggart als William Michael Rossetti |
 | Alex Best als James Collinson |
| George Laing als Frederic Stephens |
| Peter Farr als Mr. Gray |
| Nicola Draffan als Mrs. Gray |
| Saskia Keatman als Lady Rondell |
| Kelly Healey als Lady Dashwood |
| Frida Baranek als Duchess di Alba |
 | Tigerlily Hutchinson als Young Effie, Borghese Gallery |
| Iain Marshall als Mr. McPhail |
| Richard Laxton | Director |
| Emma Thompson | Screenplay |
| Andreas Roald | Producer |
| Donald Rosenfeld | Producer |
| Sarah Wheale | Line Producer |
| Paul Cantelon | Original Music Composer |
| Andrew Dunn | Director of Photography |
| Kate Williams | Editor |
| Celestia Fox | Casting |
| James Merifield | Production Design |
| Paul Ghirardani | Art Direction |
| Juliana Overmeer | Art Direction |
| Sara Wan | Set Decoration |
| Ruth Myers | Costume Design |
| Anita Anderson | Hairstylist |
| Anita Anderson | Makeup Artist |
| Konnie Daniel | Makeup Designer |
| Konnie Daniel | Hair Designer |
| Ryan Bohan | Production Manager |
| Jack Ravenscroft | First Assistant Director |
| Craig Cheeseman | Property Master |
| Blake Maslin | Greensman |
| Ian Whiteford | Greensman |
| Paul Rigby | Carpenter |
| Mark Wallis | Carpenter |
| Jamie Baker | Foley Editor |
| Michael Barry | Sound Re-Recording Mixer |
| Kam Chan | Foley Editor |
| Colin Gregory | Boom Operator |
| Paul Hsu | Supervising Sound Editor |
| Frank Kern | Foley Editor |
| Marissa Littlefield | ADR Editor |
| Branka Mrkic | Dialogue Editor |
| Allan Zaleski | Sound Effects Editor |
| Neal Champion | Special Effects Supervisor |
| Stephanie Lelievre | Stunts |
| Nicola Dove | Still Photographer |
| Ian Franklin | Rigging Gaffer |
| Dermot Hickey | First Assistant Camera |
| Andy Long | Gaffer |
| Rod Marley | First Assistant Camera |
| Ossie McLean | Camera Operator |
| Paolo Sartori | Rigging Gaffer |
| Gerry Vasbenter | Steadicam Operator |
| Catherine Buyse Dian | Costume Supervisor |
| Deborah Tallentire | Tailor |
| Rebecca Lloyd | First Assistant Editor |
| Naomi Spiro | First Assistant Editor |
| Fabrizio Cerato | Location Manager |
| Pat Karam | Location Manager |
| Stefano Dalla Lana | Location Manager |
| Suzana Peric | Music Editor |
| Kim Armitage | Script Supervisor |
| Randall Balsmeyer | Title Designer |
| Simonetta Di Fresco | Production Coordinator |
| Dale Mercer | Choreographer |
| Colin Nicolson | Sound Mixer |
