 | Michael Cera als Fred |
 | Jamie Kennedy als Mateus |
 | Matthew Lillard als Himself |
 | Frankie Muniz als Chuck |
 | Ryan Pinkston als Mike |
 | Patrick J. Adams als Male Voice (voice) |
 | Denise Boutte als New Tabitha |
 | Brian Burt als Dancer |
 | Rich Ceraulo Ko als Angus |
 | Vanessa Lee Chester als Charlotte |
 | Dennis Cockrum als Len's Dad |
 | Byron Cotton als David |
 | Nicholas D'Agosto als Evan |
| Shasa Dabner als Lindsey |
 | Christina DeRosa als Nancy |
 | James Eckhouse als Jessica's Dad |
| Danny Ehrhardt als Biff |
| Jane Silvia als Female College Student |
 | John Farley als Mr. Matthews |
 | Meagen Fay als Len's Mom |
 | Ben Feldman als Len |
 | Dan Finnerty als Gigundocock |
 | Adam Frost als Male College Student |
 | Simona Fusco als Hot Blonde |
 | JoAnna Garcia als Sweetie-Pie |
 | Kyle Gass als Director |
| Murray Gershenz als Jake |
| Brentley Gore als Assistant Director |
 | Dona Hardy als Molly |
 | Danneel Ackles als Melissa |
 | Hank Harris als Ronny |
 | Margo Harshman als Ted's Girlfriend |
 | Kevin Hart als Barry |
 | Heather Hogan als Kat |
 | Kyle Howard als Boyfriend |
| Antonio Hudnell als Dancer |
 | Donna Kimball als Blue Bally (voice) |
| Kendra Krull als Judy |
 | Vanessa Lengies als Carla |
 | Philip Lenkowsky als Clerk |
| Margie Loomis als Older Lady |
 | Bobbi Sue Luther als Gabriela |
 | Sonia Rockwell als Kim |
 | Cristin Michele als Jackie |
 | Andy Milonakis als Justin |
 | Beverley Mitchell als Sue |
| 'Big' LeRoy Mobley als Guy #2 |
| Ms. P. als Tabitha |
 | Steven Christopher Parker als Doug |
 | Marcus T. Paulk als Wyatt |
 | Rob Pinkston als Griffin |
| Allison Queal als Little Person #2 |
| Shacolby Randell als Guy #1 |
| Luigi Francis Shorty Rossi als Little Person #1 |
 | Jake Sandvig als Hank |
 | Ashley Schneider als Betty |
 | Rachel Specter als Blonde |
 | Mindy Sterling als Jane |
 | Jeremy Suarez als RJ |
| Anne Son als Roommate |
 | Ed Trotta als Lincoln |
| Kira Verrastro als Chick |
 | Katie Walder als Drunk Girl |
 | Rheagan Wallace als Jessica |
 | Jermaine Williams als Leon |
 | Cherilyn Wilson als Stacy |
| Mika Winkler als Little Person #3 |
| Royal Binion als Basketball Boner Guy (uncredited) |
| Pat Brymer als Blue Bally (uncredited) |
 | Chris Cooper als FBI Agent Mike (uncredited) |
| Blake French als Basketball Guy (uncredited) |
| Aaron Haedt als Guy in Underwear (uncredited) |
| Lisa Richman als Jessica's Mom (uncredited) |
 | John Westernoff als Guy in Underwear (uncredited) |
| Victor Macias | Camera Operator |
| David Rapaport | Casting |
| Erik Dehkhoda | Compositor |
| Bruce Green | Editor |
| Todd Bozung | Music Editor |
| Warren Zide | Producer |
| Martin Luther McCoy | Stand In |
| Eric Haase | Director of Photography |
| Lindsey Hayes Kroeger | Casting |
| Will Forte | Writer |
| Richard Suckle | Producer |
| Caitlin McKenna | ADR Voice Casting |
| Akiva Schaffer | Writer |
| Andy Samberg | Writer |
| Jorma Taccone | Writer |
| Adam Jay Epstein | Director |
| Adam Jay Epstein | Writer |
| Andrew Jacobson | Director |
| Matthew Stein | Production Executive |
| Marc Schaffer | Stunts |
| Michael C. Cuddy | Co-Producer |
| Joel C. High | Music Supervisor |
| Phil Lord | Writer |
| Alisa McCoy | Unit Production Manager |
| Alisa McCoy | Script Consultant |
| John Solomon | Writer |
| Daniel Curet | Key Hair Stylist |
| Christopher Miller | Writer |
| Greg Mauer | Foley Mixer |
| Trip Brock | Supervising Sound Editor |
| Elliot Greenberg | Editor |
| Dayna Pink | Costume Designer |
| Paul Tirone | Other |
| Mark F. Dennett | Boom Operator |
| A.J. Ullman | Visual Effects Producer |
| Steven Avila | Sound Effects Editor |
| Peter D. Lago | Sound Effects Editor |
| Russell M. Jaeger | Production Designer |
| Todd Barron | Camera Operator |
| Erica Rivinoja | Writer |
| Donna Kimball | Other |
| Jim Latham | Music |
| Jim Latham | Score Engineer |
| Jim Latham | Orchestrator |
| Andy Jacobsen | Writer |
| Meike Schlegel | Craft Service |
| Jakub Durkoth | Art Direction |
| Rudolf Weber | Stunt Coordinator |
| Sara Krueger | On Set Dresser |
| Erich Stratmann | Music Editor |
| Rick Owens | Foley Artist |
| Erick Geisler | Visual Effects Supervisor |
| Ralph Costanza | Producer |
| Lacey Terrell | Still Photographer |
| Bob Chefalas | Other |
| Gene Alford | Transportation Captain |
| Marcella Bremond | Script Supervisor |
| Brian S.M. Wroth | Dialogue Editor |
| Adam DeCoster | Foley Artist |
| Jonathon Bradley | Gaffer |
| Leo Ibanez | Dolly Grip |
| Ivan Victor | Editor |
| Ben Whitver | Foley Editor |
| Amy Brownson | Key Costumer |
| Dave Preston | Property Master |
| Kamil Korus | Art Department Assistant |
| Katrina Wolfe | Other |
| Marcus Ricaud | Boom Operator |
| Laura Lichstein | Executive Producer |
| Archie Hankins | Other |
| Shane Buttle | Electrician |
| Corey Deist | Costumer |
| Rebecca Rienks | Music Supervisor |
| Bela Trutz | Steadicam Operator |
| Keith Jones | First Assistant Camera |
| Shane T. Anderson | Stunts |
| Jonathan Sacks | Orchestrator |
| Katie Baccaro | Production Supervisor |
| Vidal Cohen | Key Grip |
| Tim Soronen | Grip |
| Kami Laprade | Other |
| Dan Ming | First Assistant Camera |
| Mary Jo Devenney | Additional Sound Re-Recording Mixer |
| Mary Jo Devenney | Playback Coordinator |
| Walter 'Bud' Scott | Key Grip |
| Essie Cha | Makeup Department Head |
| Essie Cha | Prosthetics |
| Bryan Fletchall | Other |
| John Loveall | Grip |
| Michael A. Savage | Grip |
| Michael Fastoso | Grip |
| Ilana Cohn | Other |
| Brian Ferguson | Set Decoration |
| Tom Ceglia | Additional Effects Development |
| Vitek Kral | Sound Engineer |
| Cody Smith | Animal Coordinator |
| Greg Brooks | Dolly Grip |
| Darren McEvoy | Construction Coordinator |
| Saravoot Kaitkalang | Boom Operator |
| Doug Latislaw | ADR Mixer |
| Chris Sestric | Other |
| Steve Hart | Stunt Coordinator |
| Adam Klemens | Conductor |
| Ryan Huston | Electrician |
| Annie Wildmoser | Other |
| Robert Ahrens | Location Manager |
| Melissa Gelmo | Other |
| Coleman L. Hart | Best Boy Grip |
| Jennifer Zolten Freed | Post Production Accountant |
| David Kekone | Art Department Assistant |
| Sharon L. Craig | Production Accountant |
| Pamela Chizema | First Assistant Accountant |
| André Des Rochers | Production Consultant |
| Jason Mittleman | Other |
| Craig Sharmat | Additional Music |
| Jonathan Gray | Production Consultant |
| Daniel H. Goldstein | Electrician |
| David Massey | Second Second Assistant Director |
| Derek Oishi | Other |
| Keith Shelton | First Assistant Director |
| Debe Waisman | Extras Casting |
| Scott Eades | Grip |
| Tara Buenaventura | Location Scout |
| Eric Leverenz | Other |
| Casey Ellison | Best Boy Electric |
| Aaron Pyke | Carpenter |
| Megan Oliver | Set Painter |
| Joel Marich | Set Production Assistant |
| Leslie Rodier | Post Production Supervisor |
| Rick Peebles | Grip |
| J. Starr | Additional Music |
| Andrew Bardusk | Compositor |
| Danny Coughlin | Driver |
| Jon Haaz | Property Master |
| Joe Broderick | Steadicam Operator |
| Steve Salani | Sound Engineer |
| Carter Smith | Second Assistant Camera |
| Alex Saltzman | Intern |
| Pat Brymer | Other |
| Andrew Kramer | Business Affairs Coordinator |
| Suzanne Dietz | Second Assistant Camera |
| Charles Price | Carpenter |
| Delfina Garfias | Second Assistant Camera |
| Steve Delgado | Grip |
| Jessica Allen | Smoke Artist |
| John Ober | Driver |
| Lauder Robinson | Second Second Assistant Director |
| Kevin Muir | Location Manager |
| Anna Moulaison | Second Assistant Director |
| Lindsay Schoch | Other |
| Laura Kelly | Stand In |
| Mark Matnesky | First Assistant Camera |
| Nicole Turegano | Second Assistant Camera |
| Kevin Sarnoff | Additional Camera |
| Melissa Strater | Sound Post Production Coordinator |
| Stephanie Kremer | General Manager |
| Abby Winnick | Music Coordinator |
| Celia Carter | Other |
| Susannah Crowley | Other |
| Kyle Hill | Other |
| James Bettridge | Graphic Designer |
| Rio Redd | Rotoscoping Artist |
| Michael Sepulveda | Visual Effects Assistant Editor |
| Randall Lawson | Sound Mixer |
| Jon Hicks | Cableman |
| Aaron Peterson | Electrician |
| Ryan James | Electrician |
| Charles Dalrymple | Electrician |
| Ronald Detorres | Electrician |
| Carlos Chairez | Electrician |
| Chris Quezada | Electrician |
| Clayton Deperna | Electrician |
| Scott Romsos | Electrician |
| Don Richard Curtis | Electrician |
| John Haynes | Electrician |
| Joseph Prado | Grip |
| Tim Herrman | Grip |
| Paul Aglione | Key Set Production Assistant |
| Kwame O. Kelly-Barlow | Set Production Assistant |
| Matthew Bremond | Set Production Assistant |
| Amanda Connors | Intern |
| Yaron Caplan | Art Department Assistant |
| Roger Gunnip | Art Department Assistant |
| Ryan Backus | Art Department Assistant |
| Liz Modena | Post Production Accountant |
| Josh Vignery | Assistant Location Manager |
| Allan Hagan | Location Scout |
| Kevin Golden | Casting Assistant |
| Branden Pearl | Studio Teacher |
| Blake Addison | Carpenter |
| Jamie Shaab | Carpenter |
| Bruce Miyaki | Carpenter |
| Tim Patterson | Art Department Coordinator |
| William Cancienne | Leadman |
| Dan Norman | Swing |
| DM Casper | Swing |
| Rick Dodson | Swing |
| Brent Smith | Swing |
| Michelle Hayes | Assistant Makeup Artist |
| Tambra Sales | Key Hair Stylist |
| Stephen C. Lloyd | Visual Effects Supervisor |
| Steve Curcuru | Storyboard Artist |
| Alisa Gentry | Medical Consultant |
| Josh Humphrey | Medical Consultant |
| Michael McLaughlin | Medical Consultant |
| Nicole Lopiccolo | Medical Consultant |
| Keith Gallina | Medical Consultant |
| Timothy Joyce | Medical Consultant |
| Hayden Rosenaur | Animal Wrangler |
| Fernando Diaz Barrisa | Lead Painter |
| Petra Nussbaumer | Set Painter |
| Christopher Kelly | Set Painter |
| Daniel Grell | Set Painter |
| Reggie Piert | Set Painter |
| Doreen Carpenter | Transportation Coordinator |
| Matthew Howard | Transportation Captain |
| Alan Smith | Driver |
| Brian Allen | Driver |
| Jean Pierre Ochoa | Driver |
| Vanessa Carpenter | Driver |
| John Karr | Police Consultant |
| Stephen Ellis | Police Consultant |
| Charles Baird | Other |
| Richard Sweeney | Other |
| Martin Montano | Catering Head Chef |
| Armando Penaloza | Catering Head Chef |
| Alan A. Wiljakainen | Other |
| Jeremy Brown | Other |
| Colin Gill | Title Designer |
| Martin Zeichner | Colorist |
| Matthew Landon | Other |
| Sarah Sobel | Business Affairs Coordinator |
| Rachel Levy | Executive Music Producer |
