 | Ryan Gosling als Neil Armstrong |
 | Claire Foy als Janet Shearon |
 | Jason Clarke als Ed White |
 | Kyle Chandler als Deke Slayton |
 | Corey Stoll als Buzz Aldrin |
 | Patrick Fugit als Elliot See |
 | Christopher Abbott als David Scott |
 | Ciarán Hinds als Robert R. Gilruth |
 | Olivia Hamilton als Patricia White |
 | Pablo Schreiber als Jim Lovell |
 | Shea Whigham als Gus Grissom |
 | Lukas Haas als Michael Collins |
 | Ethan Embry als Pete Conrad |
 | Brian d'Arcy James als Joseph A. Walker |
 | Cory Michael Smith als Roger B. Chaffee |
 | Kris Rey als Marilyn See |
 | Gavin Warren als Young Rick Armstrong |
 | Luke Winters als Older Rick Armstrong |
 | Connor Blodgett als Mark Armstrong |
| Lucy Stafford als Karen Armstrong |
 | J.D. Evermore als Christopher C. Kraft Jr. |
 | Leon Bridges als Gil-Scott Heron |
 | Steve Coulter als Guenter Wendt |
 | Skyler Bible als Richard F. Gordon Jr. |
 | William Gregory Lee als Gordon Cooper |
 | Choppy Guillotte als John Young |
| Braydyn Nash Helms als Young Ed White Jr. |
 | Edmund Grant als Older Ed White Jr. |
| Callie Brown als Young Bonnie White |
| Claire Smith als Older Bonnie White |
 | Brady Smith als Butch Butchart |
 | John David Whalen als John Glenn |
 | Matthew Glave als Chuck Yeager |
 | Rodney J. Hobbs als X-15 Flight Surgeon |
 | Kermit Rolison als George Mueller |
 | Willie Repoley als Jim Fucci |
 | Ben Owen als John Hodge |
| Jim Stearns als David Hammock |
| James H. Williams als Pastor |
| Helen S. Jackson als Louise Sheron |
 | Ambrit Millhouse als Syringe Tech |
 | Mark Armstrong als Paul Haney |
 | Kevin Buttimer als MSC Entrance Guard |
 | Dustin Lewis als Ralph Morse |
 | Robert Hatch als Joe Schmitt |
 | Anna Chazelle als White House Staffer |
 | Tyner Rushing als White House Staffer |
 | Myra Brown als White House Attendant |
| Ronald Hicks als White House Attendee |
 | Lawrence Jonasson als White House Attendee |
 | Irina Labouz als White House Attendee |
 | Anthony Paolucci als Jim |
 | Philip Boyd als Reporter |
| Stephanie Turner als Kelsey |
| Timothy Batten als ABC Reporter |
 | Aurelien Gaya als Agence France Reporter |
| Todd Truley als Houston Post Reporter |
 | Mark Kelly als Reporter - Apollo 11 |
 | Tim Olcott als Reporter - Apollo 11 |
 | Andrea Maria Hintermaier als Hamburg Press |
 | Jamie Anne Allman als Times Reporter |
 | Charles Carroll als Senator |
 | Brian Mahoney als Fire Inspector |
 | Donald Watkins als Protestor |
| Tess Oakland als Diner Patron |
| Michael Lee Kimel als Bill Moon |
| Ryan Clay Forbes als Bill Anders |
 | Joshua Powell als MC Engineer |
 | Thomas Clay Strickland als MC Engineer |
| Brad Kitchen als Assistant Flight Director |
| Tim Harper als Flight Activities Director |
| Andrew Armstrong als Booster Flight Controller |
| Kevin Johnson als CSQ Agena Systems |
| Damian Lovello als CSQ Gemini Systems |
 | Nelson Bonilla als NASA PAO |
| Shawn Eric Jones als Wally Schirra (uncredited) |
| Andrew Stahl als Ken Mattingly |
| Mark Kirkman als MCC Fido |
| Brian David McCay als MCC Retro |
| Mark Schlichting als MCC GNC |
| Mark Yurgil als MCC EECOM |
| Andrew Buckman als MCC Guidance |
| Christopher Sgubin als MCC Network |
| Greg Puckett als Charles Berry (uncredited) |
 | Perry Zulu Jr. als Robert Lawrence (uncredited) |
| Kent Wagner als Fred Haise (uncredited) |
| Katelyn Davis als Sally See (uncredited) |
| George Linkenback als Col. Frank Borman (uncredited) |
 | Milton Saul als Reporter (uncredited) |
 | Aaron J. Brooks als NASA Pilot (uncredited) |
 | John F. Kennedy als Self (archive footage) (uncredited) |
| Steven Spielberg | Executive Producer |
| Francine Maisler | Casting |
| Wyck Godfrey | Producer |
| Mary Zophres | Costume Design |
| Kathy Driscoll | Casting Associate |
| Donna O'Neal | Costume Supervisor |
| Thomas Valentine | Art Direction |
| Nathan Crowley | Production Design |
| Marty Bowen | Producer |
| Adam Merims | Executive Producer |
| Galen Goodpaster | ADR Editor |
| Mildred Iatrou | Supervising Sound Editor |
| Kathy Lucas | Set Decoration |
| Jeffrey Harlacker | Co-Producer |
| Dylan Goss | Aerial Director of Photography |
| Richard Blake Wester | Leadman |
| Damien Chazelle | Director |
| Damien Chazelle | Producer |
| Lon Haber | Publicist |
| Nick Brandon | Stunt Coordinator |
| Fontella Boone | Tailor |
| Linus Sandgren | Director of Photography |
| Eric Sundahl | Art Direction |
| Sarah Contant | Set Designer |
| J.D. Schwalm | Special Effects Supervisor |
| Scott Robertson | First Assistant Director |
| Tom Cross | Editor |
| Steve Hinton | Pilot |
| Josh Singer | Screenplay |
| Josh Singer | Executive Producer |
| Bill McClelland | Camera Operator |
| Donald Mowat | Makeup Department Head |
| William Conacher | Dialect Coach |
| Bruce DiValerio | Construction Coordinator |
| Dan O'Connell | Foley Artist |
| Lee Gilmore | Sound Effects Editor |
| Elisa Carlson | Dialect Coach |
| John T. Cucci | Foley Artist |
| Ai-Ling Lee | Sound Designer |
| Stephen Crowley | Gaffer |
| Rose Locke | Extras Casting |
| Harry Yoon | Additional Editing |
| Susan Dawes | Supervising Dialogue Editor |
| James M. Churchman | Stunt Coordinator |
| James M. Churchman | Second Unit Director |
| Ian Hunter | Visual Effects |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Jon Taylor | Sound Re-Recording Mixer |
| Jenne Lee | Assistant Art Director |
| Andrew Birdzell | Set Designer |
| Sheila Waldron | Script Supervisor |
| Tim McGovern | Visual Effects Supervisor |
| Mayumi Konishi-Valentine | Set Designer |
| Kevin Elam | Associate Producer |
| Jerry DeCarlo | Hairstylist |
| Nia Hansen | Sound Effects Editor |
| Phil Barrie | Sound Effects Editor |
| Jonathan R. Hodges | Property Master |
| Danielle Couture | Scenic Artist |
| Benjamin Nowicki | Art Direction |
| Justin Hurwitz | Original Music Composer |
| Daniel C. McFadden | Still Photographer |
| Jason Ruder | Supervising Music Editor |
| Justin O'Neal Miller | Art Direction |
| Adam Hart | Stunts |
| Leigh Bell | Key Costumer |
| Dean Bailey | Stunts |
| Wyatt Belton | Hairstylist |
| Matthew Harrison | Foley Editor |
| Marie Larkin | Hair Department Head |
| Isaac Klausner | Producer |
| Robert Nagle | Stunts |
| Robert Nagle | Stunt Driver |
| John To | Additional Editor |
| Mark Pappas | Foley Editor |
| Mary H. Ellis | Sound Mixer |
| Rory Bruen | Art Direction |
| Synithia Cochran | Seamstress |
| Steve Zigler | Rigging Gaffer |
| John Gilbert | Stunts |
| John Moredock | Set Designer |
| Jim Magdaleno | Storyboard Artist |
| Jeff Gomillion | ADR Mixer |
| Carla Bailey | Scenic Artist |
| Davon Slininger | Camera Operator |
| Eric Kench | Assistant Editor |
| Allan Padelford | Stunts |
| Allan Padelford | Stunt Driver |
| Anthony Cady | Key Grip |
| Danelle Davenport | Storyboard Artist |
| Rachael M. Roth | Unit Publicist |
| David Tye | Sculptor |
| Steve Cainas | Production Coordinator |
| Ross Jones | Dolly Grip |
| Jennifer Stellema | First Assistant Editor |
| Frédéric North | Pilot |
| Derek Drouin | First Assistant Editor |
| Ashley Hallford | Casting Assistant |
| Andy Hoehn | First Assistant "B" Camera |
| Ben Skorstad | Pilot |
| Erik Osusky | Art Direction |
| Jorge Sánchez | First Assistant "A" Camera |
| Kaylee Swisher | Makeup Artist |
| Molly Miller | Stunts |
| Jay Ferrara | Hairstylist |
| Michael J. Davis | Best Boy Electric |
| Richard Duarte | Foley Mixer |
| Paul Lambert | Visual Effects Supervisor |
| Thomas J. O'Connell | ADR Mixer |
| Riley 'Sean' Jones | Assistant Property Master |
| James R. Hansen | Co-Producer |
| James R. Hansen | Book |
| Katelyn Barton | Key Makeup Artist |
| Jack Cucci | Foley Mixer |
| Phillis Lehmer | Graphic Designer |
| Spencer Taylor | Second Second Assistant Director |
| Tristan Myles | Visual Effects Supervisor |
| Andrew Stahl | Second Assistant Director |
| Ryan Green | Stunts |
| Melissa Fisher | Second Assistant "A" Camera |
| Stephanie Logan | Costume Coordinator |
| Lena Glikson | Music Editor |
| Philip Ginolfi | Construction Foreman |
| Jameson Buston | Leadman |
| Tom Brown | Music Arranger |
| Jodi Diodati | Scenic Artist |
| Phillip Trujillo | Assistant Editor |
| Frankie Zamora | Best Boy Grip |
| Victor Paz | Hairstylist |
| Anthony Beddington | Propmaker |
| Zachary Bothwell | Propmaker |
| Luke Castleberry | Greensman |
| Michele Dobbs | Scenic Artist |
| Wyman Heath | Propmaker |
| Duane Hitt | Propmaker |
| Ethan Kitchens | Greensman |
| Kenneth Miles | Greensman |
| Kevin Welborn | Scenic Artist |
| James Bowman | ADR Mixer |
| Drew S. Holden | Rigging Grip |
| Paul E. Woods | Second Assistant "B" Camera |
| Kate Cavendish | Publicist |
| Abigail Hilton | Studio Teacher |
| Douglas Settles | Production Secretary |
| Daniel Vice | Set Medic |
