 | Elliot Page als Courtney |
 | Diego Luna als Ray |
 | Nina Dobrev als Marlo |
 | James Norton als Jamie |
 | Kiersey Clemons als Sophia |
 | Beau Mirchoff als Brad Mauser |
 | Wendy Raquel Robinson als Sophia's Mother |
 | Kiefer Sutherland als Dr. Barry Wolfson |
 | Madison Brydges als Tessa |
 | Jacob Soley als Alex |
 | Anna Arden als Alicia |
 | Miguel Anthony als Cyrus Gudgeon |
 | Jenny Raven als Irina Wong |
 | Charlotte McKinney als Girl on Bicycle |
 | Steve Byers als Marlo's Brother |
 | Lisa Codrington als Chief Resident |
 | Emily Piggford als Neurology Resident #1 |
 | Martha Girvin als Neurology Resident #2 |
 | Taylor Trowbridge als Lauren |
 | Nadine Whiteman als Paramedic #1 |
 | Richard Young als The Dean's Secretary |
 | Mary Grant als Radiologist |
 | Stefano DiMatteo als Paramedic #2 |
 | Jimi Shlag als Burly Patient |
 | Natasha Bromfield als ICU Nurse |
 | Daniela Barbosa als Hayley |
 | Jelena Savić als Conference Room Medical Student |
 | Brian King als Chemistry Teacher |
| Ali Schwartz als Mean Girl #1 |
| Dallas Poynter als Mean Girl #2 |
| Avery Bederman als Mean Girl #3 |
| Danny Gallagher als TEMC Dean |
 | Jessica Rose als Puzzle Nurse |
| Corey Chainey als Medical Student |
 | Janet Porter als E.R. Doctor |
| Niels Arden Oplev | Director |
| Ben Ripley | Screenplay |
| Angela Demo | Casting |
| Nathan Barr | Original Music Composer |
| Michael Bederman | Executive Producer |
| Christine Ebadi | Stunts |
| Larissa Stadnichuk | Stunts |
| Mary Kirkland | Set Decoration |
| Rose-Mary Holosko | Makeup Department Head |
| Seth Martiniuk | Compositors |
| Avery Queffelec | Stunts |
| Kerry Spurrell | Property Master |
| Scott McManus | Utility Sound |
| Audra Gorman | Location Manager |
| Michael Gibson | Still Photographer |
| Matthew Kamba | Post Production Assistant |
| Stevie Ramone | Compositors |
| Kristina Walker | Compositors |
| Patrick Kerton | Stunts |
| Daryl Patchett | Stunts |
| Michael Bederman | Unit Production Manager |
| Brent Robinson | Underwater Camera |
| Rebecca Muise | Assistant Production Coordinator |
| John Buchan | Local Casting |
| Mike Curran | Transportation Coordinator |
| Eryne Prine | Foley Editor |
| Stephanie Landriault | Compositors |
| Sohail Shimi | Compositors |
| Sarah Hoedlmoser | Stunts |
| Chris Mark | Stunts |
| Kelly Wright | Production Sound Mixer |
| Jeffrey Simlett | Dialect Coach |
| Maureen Ross | Apprentice Sound Editor |
| Jeremy Borum | Orchestrator |
| Anny Lang | Compositors |
| Inna Itkin | Lighting Artist |
| Mark Neysmith | Quality Control Supervisor |
| David Blackman | Executive Producer |
| Ana Shepherd | Stunts |
| Simon Fawcett | Co-Executive Producer |
| Daniel Mermelstein | Compositors |
| Mahvash Tehrani | Compositors |
| Tom Elkins | Editor |
| Hassan Taher | Executive Producer |
| Peter Safran | Producer |
| Brook Jones | Stunts |
| Robert Tagliaferri | First Assistant Camera |
| William Cheng | Set Designer |
| Peter Schultz | Sound Designer |
| Jim Schultz | Music Editor |
| Wesley Sewell | Visual Effects Supervisor |
| George Macri | Visual Effects Producer |
| Alex Basso | Compositors |
| Cale Schmidt | Compositors |
| Wayne Downer | Stunts |
| Michaela Cheyne | Art Direction |
| Ritchie Miazek | Transportation Captain |
| Wendy Nomiyama | Assistant Editor |
| Mandell Winter | Supervising Sound Editor |
| Larry Rench | Orchestrator |
| David Clayton | Title Designer |
| Wes While | Compositors |
| James Chretien | Lighting Artist |
| Brian Zhang | Visual Effects Editor |
| Robert Mitas | Executive Producer |
| Sean Sealey | Camera Operator |
| Tim Davis | Video Assist Operator |
| Penka Kouneva | Orchestrator |
| Josh Novak | Animation Supervisor |
| Andrew McPhillips | CG Supervisor |
| Peter Giliberti | Animation Supervisor |
| Jennifer Maillet | Compositors |
| Christian Moreton | Compositors |
| Asim Khan | Lighting Artist |
| Zoya Rezaie | Visual Effects Editor |
| Matt Birman | Stunts |
| Danny Lima | Stunts |
| Warren Scherer | Stunts |
| Steev Beeson | Production Accountant |
| Kirk Cheney | Construction Coordinator |
| Sang Kim | Assistant Sound Editor |
| Kayla Cabral | Visual Effects Coordinator |
| Geoff Sayer | Compositors |
| Dino Brancatella | Stunts |
| Dawn Rivard | Hairstylist |
| Rod Benjamin | Key Grip |
| Emily Cook | Casting Associate |
| David Esparza | Sound Re-Recording Mixer |
| Rachel Beniuk | Compositors |
| Karl Irvine | Second Assistant Director |
| Justin Haut | Production Coordinator |
| Missy Dingman | Third Assistant Director |
| Stefni Colle | Casting Associate |
| Martin Drover | Transportation Co-Captain |
| Gershon Hinkson | First Assistant Editor |
| Annie G. Pizzuto | Apprentice Sound Editor |
| Felix Famelart | Stunts |
| Dave Lewis | Stunts |
| Jesse Nye | First Assistant Director |
| Justin Ardalan-Raikes | Co-Executive Producer |
| Arthur E. Cooper | Camera Operator |
| Sean Sealey | Steadicam Operator |
| David McKane | First Assistant Camera |
| Sophia Welch | Casting Assistant |
| Barb Benoit | Compositors |
| Joseph Ankrah | Compositors |
| Douglas Gibbens | Visual Effects Editor |
| Eric Kress | Director of Photography |
| Laurence Mark | Producer |
| Karola Dirnberger | Hair Department Head |
| Kelly Shanks | Hairstylist |
| Karen Pidgurski | Unit Publicist |
| Beth Mell | Third Assistant Director |
| Robin Whittaker | Music Editor |
| Jason Kolodzeijczak | Compositors |
| Dennis Ngariuku | Compositors |
| Yan Dai | Compositors |
| Alex Hirtenstein | Compositors |
| Jignesh Patel | Compositors |
| Mike Barber | Visual Effects Editor |
| Brian Oliver | Executive Producer |
| Simon Girard | Stunts |
| Mark Agnes | Costume Supervisor |
| Kaz Kobielski | Special Effects Supervisor |
| Srđan Vilotijević | Location Manager |
| Bryan Pettibone | Post Production Assistant |
| David Esparza | Sound Designer |
| Dhyana Carlton-Tims | Dialogue Editor |
| Mahsa Ghorbankarimi | Lighting Artist |
| Niels Sejer | Production Design |
| Peter Filardi | Story |
| Layton Morrison | Stunt Coordinator |
| Cotton Mather | Stunts |
| Carolyn Arbuckle | Script Supervisor |
| Michael Innanen | Special Effects Coordinator |
| Jason Knight | Local Casting |
| Debra L. Tennant | Additional Editing |
| Carolyn Calvert | Assistant Editor |
| Ryan Collins | Sound Effects Editor |
| Lee Zhu | Compositors |
| Richard Rodrigues | Compositors |
| Abhijith Sathyan | Compositors |
| Travis Gagne | Visual Effects Editor |
| Kelly Robertson-Reinhart | Assistant Production Manager |
| Wayne Godfrey | Key Costumer |
| Don Kozma | Makeup Department Head |
| Sandra Wheatle | Makeup Artist |
| David Giammarco | Sound Re-Recording Mixer |
| Mitch Hounslow | Visual Effects Editor |
| Vivek Sharma | Compositors |
| Joseph Roth | Assistant Editor |
| Alexander Turner | Boom Operator |
| Edward Lipscombe | Rigging Grip |
| Christopher Takacs | Rigging Gaffer |
| Terry Banting | Gaffer |
| Arthur E. Cooper | Second Unit Director of Photography |
| Dave Erlichman | Dolly Grip |
| Sue Parker | Stunts |
| Jenny Gering | Costume Designer |
| Michael Douglas | Producer |
| Steve Newburn | Prosthetic Designer |
| Vibhuti Rathod | Assistant Director |
| Michael Derrah | Storyboard Artist |
| Greg Gilmore | First Assistant Art Direction |
| Greg Gilmore | Graphic Designer |
| Jay Graham | Sculptor |
| Stefany Koutroumpis | First Assistant Art Direction |
| Itsuko Kurono | First Assistant Art Direction |
| Catherine Lam | Set Designer |
| Ken Sinclair | Leadman |
| Eric Yamamoto | Storyboard Artist |
| Anita Cannella | Foley Artist |
| Devin Doucette | ADR Mixer |
| Nerses Gezalyan | Foley Mixer |
| Robin Harlan | Foley Artist |
| Aaron Hasson | ADR Mixer |
| Sang Jun Kim | Assistant Sound Editor |
| Howard London | ADR Mixer |
| Sarah Monat | Foley Artist |
| Chris Bacik | Drone Pilot |
| Alistair Dempsey | Dolly Grip |
| Jamie Hodgson | Generator Operator |
| Dennis Kane | Assistant Chief Lighting Technician |
| Sean Keay | Electrician |
| Stephan Maia | Second Assistant "B" Camera |
| Tenzin Woeser | Electrician |
| Roisin McGilly | Extras Casting |
| Vince Deiulis | Production Secretary |
| David Murphy | Head Carpenter |
| Patrick Mark | Stunts |
| Brianna Goldie | Stunt Double |
