 | Dennis Quaid als Frank Sullivan |
 | Jim Caviezel als John Sullivan |
 | Shawn Doyle als Jack Shepard |
 | Elizabeth Mitchell als Julia Sullivan |
 | Andre Braugher als Satch DeLeon |
 | Noah Emmerich als Gordo Hersch |
 | Melissa Errico als Samantha Thomas |
 | Jordan Bridges als Graham Gibson |
 | Daniel Henson als Johnny Sullivan (6 Years) |
 | Michael Cera als Gordy Jr. (10 Years) |
 | Stephen Joffe als Gordo Hersch (8 Years) |
 | Peter MacNeill als Butch Foster |
 | Marin Hinkle als Sissy Clark |
| Jack McCormack als Commander Butch O'Connell |
 | Richard Sali als Chuck Hayes |
 | Nesbitt Blaisdell als Fred Shepard |
 | Joan Heney als Laura Shepard |
| Jessica Meyer als Teenage Runaway |
| Kirsten Bishop als Carrie Reynolds |
 | Rocco Sisto als Daryl Simpson |
| Rosemary De Angelis als Mrs. Finelli |
| John Di Benedetto als Con Ed Supervisor |
 | Terry Serpico als Con Ed Worker #1 |
 | Brian Smyj als Con Ed Worker #2 |
| Nicole Brier als Stoned Teenage Girl |
| Brantley Bush als Young Intern |
 | David Huband als Lounge Bartender |
 | Chuck Margiotta als Pedestal Man Gino |
 | Karen Glave als Lanni DeLeon |
| Frank McAnulty als Desk Sergeant |
| Derek Aasland als Stoned Man #1 |
| Jim McAleese als Cozy Bartender |
| Catherine Burdon als Young Woman #1 |
 | Jennifer Baxter als Young Woman #2 |
 | Desmond Campbell als Forensic Tech Hector |
 | Danny Johnson als Uniformed Cop #1 |
| Colm Magner als Uniformed Cop #2 |
 | Brigitte Kingsley als Bar Waitress |
| Tucker Robin als Frank Jr. |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Robert Shaye | Executive Producer |
| Steve Boeddeker | Sound Designer |
| Michael Kamen | Original Music Composer |
| Dennie Thorpe | Foley |
| Jana Vance | Foley |
| Tony Eckert | Foley Mixer |
| Brian Jagersky | Stunts |
| Andreas Schulz | Costume Supervisor |
| Robert Deschaine | ADR Mixer |
| Tami Treadwell | ADR Recordist |
| Hawk Koch | Producer |
| Teresa Eckton | Sound Effects Editor |
| Gordon Sim | Set Decoration |
| Steven Kirshoff | Special Effects Coordinator |
| John Caglione Jr. | Makeup Department Head |
| John Kasarda | Art Direction |
| Gregory Hoblit | Director |
| Gregory Hoblit | Producer |
| David Rosenbloom | Editor |
| Ron Hobbs | Storyboard Artist |
| Elisabetta Beraldo | Costume Design |
| Alar Kivilo | Director of Photography |
| Carla Fry | Executive In Charge Of Production |
| Toby Emmerich | Producer |
| Toby Emmerich | Writer |
| Bill Carraro | Producer |
| Bill Carraro | Unit Production Manager |
| Robin D. Cook | Casting |
| Jody Levin | Executive In Charge Of Post Production |
| Dennis Davenport | Art Direction |
| Paul Eads | Production Design |
| Richard Saperstein | Executive Producer |
| Jeff J.J. Authors | First Assistant Director |
| Janis Rothbard Chaskin | Executive Producer |
| Mindy Roffman | Art Direction |
| Beth Kushnick | Set Decoration |
| Patricia Graf | Associate Producer |
| Al Cerullo | Pilot |
| Gary Rizzo | Sound Re-Recording Mixer |
| Peter Epstein | Stunts |
| Tom Bellfort | Supervising Sound Editor |
| Matthias Gohl | Music Arranger |
| Craig Haagensen | Camera Operator |
| Gregory Plotkin | First Assistant Editor |
| Richmond Riedel | First Assistant Editor |
| G. A. Aguilar | Stunt Coordinator |
| Donna Maloney | Costume Supervisor |
| Jeffrey Lee Gibson | Stunts |
| Robert McRae | Gaffer |
| Donald Mowat | Makeup Artist |
| Elis Y. Lam | Set Designer |
| Nigel Churcher | Assistant Art Director |
| Cori Burchell | Costume Supervisor |
| Tom Kramer | Music Editor |
| Christopher Geggie | Property Master |
| Fred Kamping | Location Manager |
| Leslie Fuller | Makeup Artist |
| Cheryl Nardi | Assistant Sound Editor |
| Gwendolyn Yates Whittle | ADR & Dubbing |
| Gwendolyn Yates Whittle | ADR Supervisor |
| Michael Semanick | Sound Re-Recording Mixer |
| Sam Hutchins | Location Manager |
| Takashi Seida | Still Photographer |
| H. Nancy Pak | Assistant Art Director |
| Angelo Colavecchia | Camera Operator |
| Kay Michaels | Art Department Coordinator |
| David Norris | Camera Operator |
| Chris Scarabosio | Sound Effects Editor |
| Zeke Morales | Visual Effects Editor |
| Dave Staples | Transportation Coordinator |
| Candide Franklyn | Camera Operator |
| Jamie Jones | Stunts |
| Bill Myer | Makeup Effects |
| Andrea Gard | Assistant Sound Editor |
| Joe Everett | Unit Publicist |
| Deryck Blake | Assistant Property Master |
| Gary Summers | Sound Re-Recording Mixer |
| Laurel Bresnahan | Studio Teacher |
| Verne Caruso | Hairstylist |
| Brian Smyj | Stunts |
| Karen G. Wilson | Foley Editor |
| Jennifer Bower O'Halloran | Hairstylist |
| Michelle Bruno | Makeup Artist |
| Edelgard K. Pfluegl | Makeup Artist |
| Derek Becker | Makeup Effects |
| John Sweeney | Property Master |
| Neil Morfitt | Assistant Art Director |
| Michael Shocrylas | Assistant Art Director |
| Kirk Cheney | Construction Coordinator |
| Ann Marie Auricchio | Scenic Artist |
| Stephen Barth | Scenic Artist |
| Cameron S. Brooke | Scenic Artist |
| Robert C. Brooke | Scenic Artist |
| Jonathan Savan | Leadman |
| Lindakay Brown | Dialogue Editor |
| Claire Graybill | Dialogue Editor |
| J.J. Sabat Jr. | Sound Recordist |
| Roberto Smith | Animation |
| Eileen Moran | Visual Effects Producer |
| Bill Westenhofer | Visual Effects Supervisor |
| Victor Aguirre | Still Photographer |
| Jerry DeBlau | Gaffer |
| Sal Martorano | Gaffer |
| Monica Russell | Set Costumer |
| Samantha Armstrong | Script Supervisor |
| Lilene Mansell | Dialect Coach |
| Mike Kirilenko | Key Grip |
| Janice Miller | Hairstylist |
| Rick Reynolds | Post Production Supervisor |
| Bruce Lacey | Foley Editor |
| Ron Renzetti | Dolly Grip |
| Douglas Ganton | Sound Mixer |
| Reynald Trudel | Boom Operator |
| Darren McGuire | Stunts |
| Stephen McLaughlin | Scoring Mixer |
| Jane Rogers | Extras Casting |
| Len Wagner | Stunts |
| Mary Ann Stevens | Stunts |
| Joseph S. Alfieri | Construction Coordinator |
| Rick Kush | Second Assistant Director |
| Samuel Turturici | Grip |
