 | Steve Carell als Maxwell Smart |
 | Anne Hathaway als Agent 99 |
 | Dwayne Johnson als Agent 23 |
 | Alan Arkin als The Chief |
 | Terence Stamp als Siegfried |
 | James Caan als The President |
 | Bill Murray als Agent 13 |
 | Patrick Warburton als Hymie |
 | Terry Crews als Agent 91 |
 | David Koechner als Larabee |
 | Masi Oka als Bruce |
 | Nate Torrence als Lloyd |
 | Ken Davitian als Shtarker |
 | David S. Lee als Ladislas Krstic |
 | Dalip Singh als Dalip |
 | Geoff Pierson als Vice President |
 | Kelly Karbacz als Judy |
 | Arthur Darbinyan als Russian Bad Guy |
 | Bill Romanowski als Air Marshall |
 | Mark Ivanir als Russian Guy in Bathroom |
 | Lindsay Hollister als Max's Dance Partner |
 | Dimitri Diatchenko als Russian Underling |
 | Richard V. Licata als Russian Leader |
 | Greg Joung Paik als North Korean General |
 | Joey Yu als North Korean Soldier |
 | Mike Akrawi als Arab Man |
| John Abiskaron als Arab Man |
| Kerry Lai Fatt als Tour Guide |
| David A. Parker als Agent 50 |
 | Bonnie Hellman als Karen |
 | John Farley als Agent 38 |
 | Jonathan Loughran als Orange Team Guy |
 | Felisha Terrell als CONTROL Assistant |
| Jeff Tanner als CONTROL Assistant |
 | Jasper Pendergrass als Budweiser Delivery Guy |
 | Carl Crevier als Restaurant Agent |
 | David Schaap als Restaurant Agent |
| Peter Weireter als Airline Passenger |
 | Thomas Garner als Airline Passenger |
 | Danielle Bisutti als Airline Passenger |
 | Jessica Barth als Flight Attendant |
 | David Fabrizio als Pilot |
 | John Eddins als Co-Pilot |
 | Alex Kudrytsky als Russian Farmhand |
| Tatyana Kaboulova als Pretty Woman at Party |
 | Moshana Halbert als Pretty Woman at Party |
 | Sergei Priselkov als Russian Farmer |
| Jane Gilchrist als Bakery Assistant |
 | Todd Sherry als KAOS Office Worker |
 | David Aranovich als Russian Son |
 | Ivy Bethune als Russian Mother |
 | Larry Miller als CIA Agent |
 | Kevin Nealon als CIA Agent |
 | Blake Clark als General |
 | Cedric Yarbrough als Tate |
 | James Moses Black als CONTROL Prison Guard |
 | Bernie Kopell als Opel Driver |
| Michael P. Catanzarite als Secret Service Agent |
 | Tim DeKay als Secret Service Agent |
| Jerry Sherman als Conductor |
 | Matthew Glave als Secret Service Agent Driver |
 | Brad Grunberg als Golfer |
| Leonard B. Stern als Cesna Pilot |
| Sean Segal als Kid in Minivan |
 | Stephen Dunham als Secret Service Commander |
 | Jennifer De Minco als Agent |
 | Karri Turner als Mom in Minivan |
 | Ryan Seacrest als Ryan Seacrest (voice) |
 | William Charlton als German Spy #1 (uncredited) |
| Nadia David als Hotel Maid (uncredited) |
| Aurelius DiBarsanti als North Korean Soldier (uncredited) |
| Fred Fein als Golfer (uncredited) |
 | Mo Gallini als Drug Lord (uncredited) |
 | Sam Hale als Russian Hacker (uncredited) |
 | Butch Klein als Commuter (uncredited) |
| Sophia Lansky als Guest (uncredited) |
 | Joshua Leary als CONTROL Agent (uncredited) |
 | Phoebe Price als Window Shopper (uncredited) |
| Nicholas Rich als Russian Guard with Dog (uncredited) |
 | Shant Sarkissian als SWAT Agent (uncredited) |
 | Julian Scott Urena als Drug Lord (uncredited) |
| Gunter Ziegler als Russian Agent (uncredited) |
 | Vinicius Zorin-Machado als Valet #2 (uncredited) |
| Charles Roven | Producer |
| Trevor Rabin | Original Music Composer |
| Bruce Berman | Executive Producer |
| Alex Gartner | Producer |
| Peter Segal | Executive Producer |
| Matt Ember | Screenplay |
| Steve Carell | Executive Producer |
| Richard Pearson | Editor |
| Roger Mussenden | Casting |
| Peter Segal | Director |
| Dean Semler | Director of Photography |
| Michael Ewing | Producer |
| Tom J. Astle | Screenplay |
| Zachary Woodlee | Associate Choreographer |
| Aaron Benoit | Title Designer |
| Nathalie Joyal | Visual Effects Coordinator |
| Migs Rustia | Visual Effects Editor |
| Craig Hosking | Aerial Coordinator |
| J. Bryan Holloway | Sculptor |
| Lucy Coldsnow-Smith | Dialogue Editor |
| Mark G. Soper | Visual Effects Producer |
| Steve Cassidy | Aerial Camera |
| Jamal Sims | Choreographer |
| Jeffery J. Jenkins | Lead Painter |
| Doug Coleman | Stunt Coordinator |
| Mitchell Ray Kenney | Costume Supervisor |
| Rick Sharp | Makeup Department Head |
| John Hockridge | First Assistant Director |
| Nicholas Korda | ADR Editor |
| Steve Mann | Sound Editor |
| Fred L. McLane | First Assistant Camera |
| Thomas J. Cabela | Assistant Editor |
| Kokayi Ampah | Location Manager |
| Billy Bonifield | Production Coordinator |
| Jeff Nichol | Key Grip |
| Mort Segal | In Memory Of |
| Gary A. Krakoff | Construction Coordinator |
| Christopher S. Aud | Supervising Sound Editor |
| Elad Offer | Visual Effects Supervisor |
| Tony Rivetti Jr. | Still Photographer |
| Leslie E. Rollins | Set Decoration |
| Andrea Horta | ADR Editor |
| Richard Merryman | Camera Operator |
| Kim De Pietro | Location Manager |
| Wynn Thomas | Production Design |
| Lee N. Sforza | Construction Foreman |
| James J. Gilson | Chief Lighting Technician |
| Steve Durkee | Music Editor |
| Sophia Lansky | Dialect Coach |
| Charlotte Parker | Hairstylist |
| Martin Chalifoux | Construction Coordinator |
| Terry Rodman | Supervising Sound Editor |
| Eric D. Christensen | Visual Effects Supervisor |
| Kim Heath | Rigging Grip |
| Andrew Rowlands | Camera Operator |
| Simon Cassels | Title Designer |
| James Hegedus | Supervising Art Director |
| Paul Hotte | Set Decoration |
| Douglas S. Holgate | Aerial Camera |
| Kim De Pietro | Music Editor |
| Buck Henry | Characters |
| Andrew Lazar | Producer |
| Christopher Burian-Mohr | Art Direction |
| Chantal Bergeron | Hairstylist |
| Jonathan Fuh | Boom Operator |
| Steve Gilbert | Dolly Grip |
| Nancy Collini | Key Costumer |
| Nathan Gunn | Assistant Editor |
| Stuart Grusin | Music Editor |
| Tony Didio Jr. | Armorer |
| Glenn Bydwell | Set Designer |
| Susan Bierbaum | Script Supervisor |
| Caroline Alder | Art Direction |
| Martin Gendron | Art Direction |
| Nathalie Trépanier | Makeup Artist |
| Katy Wood | Dialogue Editor |
| Danny S. Kim | Visual Effects Supervisor |
| Tracy Bennett | Still Photographer |
| Joseph A. Ponticelle | First Assistant Camera |
| Kim Collea | Makeup Artist |
| Dawn Ascher-Trevino | Art Department Coordinator |
| Jonathan Bobbitt | Leadman |
| Maxime Ferland | Boom Operator |
| Michael Lantieri | Special Effects Supervisor |
| Joe Bauer | Visual Effects Supervisor |
| Eric Torres | Visual Effects Coordinator |
| James Lew | Fight Choreographer |
| Mel Brooks | Characters |
| David LeRoy Anderson | Makeup Effects |
| Carol A. O'Connell | Hairstylist |
| Annette Bélanger | Art Department Coordinator |
| Sandy Berman | Sound Editor |
| Valerie Davidson | Foley Editor |
| Jeff Sawyer | Sound Editor |
| Paul Stemmer | Visual Effects Editor |
| Bob Beher | Foley Editor |
| Juno J. Ellis | ADR Supervisor |
| Paul M. Wagner | Visual Effects Editor |
| Elizabeth Tompkins | Production Controller |
| Tom Calderaro | Orchestrator |
| Alana Mayo | Assistant Production Manager |
| John Isaacs | Hair Department Head |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Suzanne Cloutier | Set Decoration |
| Michael Roderick | Digital Compositor |
| Shauna Duggins | Stunt Double |
| John Karner | VFX Artist |
| Robin Lynn Bonaccorsi | Stunt Driver |
| Nancy Thurston | Stunts |
| Jennifer Caputo | Stunt Double |
| Meegan E. Godfrey | Stunts |
| Rick Avery | Stunt Driver |
| Diana R. Lupo | Stunt Double |
| Eliza Coleman | Stunts |
| Tad Griffith | Stunt Driver |
| Chad Tyler | Stunt Double |
| Chris Palermo | Stunts |
| Alex Betuel | Set Production Assistant |
| Deborah Lynn Scott | Costume Designer |
| Brent O'Connor | Executive Producer |
| Dana Goldberg | Executive Producer |
| Jimmy Miller | Executive Producer |
| Tanoai Reed | Stunt Double |
| Chris Howell | Stunts |
| Elana Staehli | Extras Casting Assistant |
| Mickey Giacomazzi | Stunts |
| Gene Hartline | Stunts |
