 | David Strathairn als Edward R. Murrow |
 | Patricia Clarkson als Shirley Wershba |
 | George Clooney als Fred Friendly |
 | Jeff Daniels als Sig Mickelson |
 | Robert Downey Jr. als Joe Wershba |
 | Frank Langella als William Paley |
 | Ray Wise als Don Hollenbeck |
 | Robert John Burke als Charlie Mack |
 | Reed Diamond als John Aaron |
 | Tate Donovan als Jesse Zousmer |
 | Grant Heslov als Don Hewitt |
 | Tom McCarthy als Palmer Williams |
 | Matt Ross als Eddie Scott |
 | Rose Abdoo als Mili Lerner |
 | Alex Borstein als Natalie |
 | Peter Jacobson als Jimmy |
 | Robert Knepper als Don Surine |
 | Dianne Reeves als Jazz Singer |
 | Peter Martin als Pianist |
| Christoph Luty als Bassist |
| Jeff Hamilton als Drummer |
| Matt Catingub als Saxophonist |
 | Glenn Morshower als Colonel Anderson |
 | Don Creech als Colonel Jenkins |
 | Helen Slayton-Hughes als Mary |
 | Simon Helberg als CBS Page |
 | JD Cullum als Stage Manager |
| John Kepley als CBS Lawyer #1 |
| David Paul Christian als CBS Lawyer #2 |
| Joyce Lasley als Make-Up Girl |
 | Bill Blair als TV Studio Crewman (uncredited) |
| Joseph Dowd als Reporter (uncredited) |
| Bruna Matsin als Sig Mickelson's Wife (uncredited) |
| Katharine Phillips Moser als Jesse's Wife (uncredited) |
| Alexana Thomas als Senator's Wife (uncredited) |
 | Dave Thompson als News Photographer (uncredited) |
| Rochelle Warner als Speech Wife (uncredited) |
 | Roy Cohn als Self (archive footage) (uncredited) |
 | Dwight D. Eisenhower als Self (archive footage) (uncredited) |
 | Robert F. Kennedy als Self (archive footage) (uncredited) |
 | Liberace als Self (archive footage) (uncredited) |
 | Joseph McCarthy als Self (archive footage) (uncredited) |
| John L. McClellan als Self (archive footage) (uncredited) |
| Milo Radulovich als Self (archive footage) (uncredited) |
| Joseph N. Welch als Self (archive footage) (uncredited) |
| Lance Brown | Sound Re-Recording Mixer |
| George Clooney | Screenplay |
| George Clooney | Director |
| Ellen Chenoweth | Casting |
| Steven Soderbergh | Executive Producer |
| Stephen Mirrione | Editor |
| Jennifer Fox | Executive Producer |
| Robert Elswit | Director of Photography |
| Louise Frogley | Costume Design |
| Samuel Hadida | Co-Executive Producer |
| Ron Berkeley | Key Makeup Artist |
| Simon Franks | Co-Producer |
| Zygi Kamasa | Co-Producer |
| Christa Munro | Art Direction |
| Edward Tise | Production Sound Mixer |
| James D. Bissell | Production Design |
| Jan Pascale | Set Decoration |
| Douglas Crise | First Assistant Editor |
| Barbara A. Hall | Unit Production Manager |
| Barbara A. Hall | Co-Producer |
| Marc Butan | Executive Producer |
| Ben Cosgrove | Executive Producer |
| Gae S. Buckley | Set Designer |
| Grant Heslov | Screenplay |
| Grant Heslov | Producer |
| Mark Cuban | Executive Producer |
| Victor Hadida | Co-Executive Producer |
| Kiyotaka Ninomiya | Co-Producer |
| Chris Salvaterra | Executive Producer |
| Jeff Skoll | Executive Producer |
| Todd Wagner | Executive Producer |
| Waldo Sanchez | Makeup Department Head |
| Waldo Sanchez | Hair Department Head |
| David Webb | First Assistant Director |
| Ryan Piers Williams | Camera Production Assistant |
| Tad Driscoll | Production Accountant |
| Rachel Tenner | Casting Associate |
| Diane H. Newman | Script Supervisor |
| John Roesch | Foley Artist |
| John Joseph Thomas | Sound Effects Editor |
| Melinda Sue Gordon | Still Photographer |
| Lynda Foote | Costume Supervisor |
| Joy Zapata | Key Hair Stylist |
| Tony Bonaventura | Property Master |
| Randall L. Johnson | Boom Operator |
| Susan Dudeck | Dialogue Editor |
| Charlotte Raybourn | Art Department Coordinator |
| Alyson Dee Moore | Foley Artist |
| Louise Del Araujo | Leadman |
| Colin Anderson | Camera Operator |
| Carolyn Elias | Hairstylist |
| Aaron Glascock | Supervising Sound Editor |
| Aaron Glascock | Sound Re-Recording Mixer |
| Curt Schulkey | Supervising Sound Editor |
| Curt Schulkey | Sound Re-Recording Mixer |
| Pamela Kahn | Foley Artist |
| Barry Idoine | First Assistant "A" Camera |
| Gregg Schaublin | Digital Intermediate Producer |
| J. A. Byerly | Rigging Gaffer |
| Michael Bauman | Chief Lighting Technician |
| Mary Jo Lang | Foley Mixer |
| Jeff Kunkle | Dolly Grip |
| John T. Connor | First Assistant "B" Camera |
| Karen Higgins | Construction Coordinator |
| Violet Ortiz | Hairstylist |
| Jeff Winn | Craft Service |
| Oscar Mitt | Assistant Sound Editor |
| Rocky Quiroz | Utility Sound |
| Michael Kenner | Key Grip |
| Dusty Saunders | Transportation Coordinator |
| Larissa Supplitt | Second Assistant "A" Camera |
| Simone Perusse | Assistant Chief Lighting Technician |
| Ellis J. Barbacoff | Assistant Property Master |
| Scott Morgan | Foley Recordist |
| Lucinda Campbell | Key Costumer |
| Lynne Redding | ADR Voice Casting |
| John Morris | Best Boy Grip |
| Melissa V. Barnes | Second Assistant Director |
| David D. Scott | Video Assist Operator |
| Hank Sheppherd | Key Rigging Grip |
