 | Chris Pratt als Peter Quill / Star-Lord |
 | Zoe Saldaña als Gamora |
 | Dave Bautista als Drax the Destroyer |
 | Vin Diesel als Baby Groot (voice) |
 | Bradley Cooper als Rocket (voice) |
 | Kurt Russell als Ego |
 | Michael Rooker als Yondu Udonta |
 | Karen Gillan als Nebula |
 | Pom Klementieff als Mantis |
 | Sylvester Stallone als Stakar Ogord |
 | Elizabeth Debicki als Ayesha |
 | Chris Sullivan als Taserface |
 | Sean Gunn als Kraglin / On-Set Rocket / On-Set Adolescent Groot |
 | Tommy Flanagan als Tullk |
 | Laura Haddock als Meredith Quill |
 | Aaron Schwartz als Young Ego Facial Reference |
 | Hannah Gottesman als Sovereign Chambermaid |
 | Hilty Bowen als Sovereign Pilot |
 | Ben Browder als Sovereign Admiral |
 | Alexander Klein als Zylak |
 | Luke Cook als Zylak's Frenemy |
 | Evan Jones als Retch |
 | Joe Fria als Oblo |
 | Terence Rosemore als Narblik |
 | Jimmy Urine als Half-Nut |
 | Stephen Blackehart als Brahl |
 | Steve Agee als Gef |
 | Blondy Baruti als Huhtar |
 | Richard Christy als "Down There!" |
 | Rob Zombie als Unseen Ravager |
 | Sierra Love als Robot Courtesan |
 | Kendra Carelli als Robot Courtesan |
| Milynn Sarley als Robot Courtesan |
 | Seth Green als Howard the Duck (voice) |
 | Molly C. Quinn als Howard's Date |
 | Michael Rosenbaum als Martinex |
 | Rhoda Griffis als Sneeper Madame |
 | Stan Lee als Watcher Informant |
 | David Hasselhoff als The Form of David Hasselhoff |
 | Mac Wells als Officer Fitzgibbon |
 | Jim Gunn Sr. als Weird Old Man |
 | Leota Gunn als Weird Old Man's Mistress |
 | Elizabeth Faith Ludlow als Easik Mother |
 | Wyatt Oleff als Young Peter Quill |
 | Gregg Henry als Grandpa Quill |
 | Damita Jane Howard als Grandpa Quill's Friend |
 | Ving Rhames als Charlie-27 |
 | Michelle Yeoh als Aleta Ogord |
 | Mike Escamilla als Scrote |
 | Miley Cyrus als Mainframe (voice) (uncredited) |
 | Jeff Goldblum als En Dwi Gast / Grandmaster (uncredited) |
| Donny Carrington als Kree Monk (uncredited) |
 | Brian Clackley als Alien (uncredited) |
| Nea Dune als Lovebot (uncredited) |
 | Fred Galle als Sovereign Leader (uncredited) |
 | Alphonso A'Qen-Aten Jackson als Ravager (uncredited) |
 | Kelly Richardson als Daisy Kiu (uncredited) |
 | Guillermo Rodriguez als Cop #2 (uncredited) |
 | Josh Tipis als Humanoid Ravager (uncredited) |
 | Jason Williams als Huge Guard of the Sovereign Nation (uncredited) |
 | Cheyanna Lavon Zubas als Robot Courtesan (uncredited) |
| Craig Wood | Editor |
| Craig Wood | Editorial Manager |
| Christopher Boyes | Sound Re-Recording Mixer |
| Sarah Halley Finn | Casting |
| Jay Hart | Set Decoration |
| Kathryn Himoff | Additional Editing |
| Stan Lee | Executive Producer |
| Stan Lee | Characters |
| Kevin Feige | Producer |
| Jim Palmer | Stunt Double |
| Thomas Valentine | Art Direction |
| Judianna Makovsky | Costume Design |
| James Gunn | Director |
| James Gunn | Writer |
| James Gunn | Script Supervisor |
| Tyler Bates | Music |
| Darrell Hall | Music Editor |
| Scott Chambliss | Production Design |
| Daniel Sudick | Special Effects Supervisor |
| Jack Kirby | Characters |
| Larry Lieber | Characters |
| Don Heck | Thanks |
| Henry Braham | Director of Photography |
| Dave Jordan | Music Supervisor |
| Lisa Tomczeszyn | Assistant Costume Designer |
| Louis D'Esposito | Executive Producer |
| Fred Raskin | Editor |
| Jarred Land | Thanks |
| Victoria Alonso | Executive Producer |
| Ramsey Avery | Supervising Art Director |
| Shelley Roden | Foley |
| Steve Gerber | Characters |
| Dylan Goss | Aerial Director of Photography |
| Dan Abnett | Comic Book |
| Kevin Kirkpatrick | Prosthetic Makeup Artist |
| Kent Harvey | Camera Operator |
| Barbara Harris | ADR Voice Casting |
| Arnold Drake | Thanks |
| Chris Claremont | Thanks |
| Russell Bobbitt | Property Master |
| Gene Colan | Thanks |
| John Buscema | Thanks |
| Jonathan Schwartz | Executive Producer |
| Vlad Bina | Art Direction |
| Stephen Christensen | Art Direction |
| Keith Giffen | Characters |
| David Acord | Sound Designer |
| David Acord | Supervising Sound Editor |
| Sal Buscema | Thanks |
| Harry E. Otto | Art Direction |
| Nick Scarano | Costume Supervisor |
| Jann K. Engel | Art Direction |
| Elena Albanese | Art Direction |
| Jonathan Fawkner | Visual Effects Supervisor |
| Lora Hirschberg | Sound Re-Recording Mixer |
| John Blake | Makeup Department Head |
| Kim M. Holly | Key Costumer |
| George Hull | Conceptual Design |
| Brian Adler | Visual Effects |
| Chase Paris | Casting |
| Tara Feldstein Bennett | Casting |
| Melanie Mascioli | Key Set Costumer |
| Lars P. Winther | Co-Producer |
| Andy Lanning | Comic Book |
| Lee Gilmore | Sound Effects Editor |
| Addison Teague | Sound Designer |
| Addison Teague | Supervising Sound Editor |
| David Yarovesky | Thanks |
| Steve Englehart | Characters |
| John M. 'Jack' Wright | Key Costumer |
| Jeffrey A. Humphreys | Boom Operator |
| Stacey S. McIntosh | Construction Coordinator |
| Alessandro Cioffi | VFX Supervisor |
| Alessandro Ciucci | Lead Animator |
| Jim Valentino | Thanks |
| Tiffany Busche | Set Costumer |
| Brad Semenoff | Dialogue Editor |
| Brad Semenoff | ADR Editor |
| Chad Randall | Stunts |
| Joel Thompson | Visual Effects Editor |
| Steve Constancio | Ager/Dyer |
| Guy Williams | Visual Effects |
| Grant Harris | Lead Animator |
| Jules Holdren | Key Hair Stylist |
| Dan Cornwall | Gaffer |
| Christine Youngstrom | Art Department Coordinator |
| Lisa J. Levine | ADR Supervisor |
| Christopher Townsend | Visual Effects Supervisor |
| Bill Myer | Key Makeup Artist |
| Alexei Dmitriew | Prosthetic Makeup Artist |
| Val Mayerik | Characters |
| Lorena Talpan | Visual Effects Editor |
| Camille Friend | Hair Department Head |
| Jerad Marantz | Concept Artist |
| Tom Fendley | Rigging Gaffer |
| Corbin Mehl | Visual Effects Editor |
| James Baker | Pre-Visualization Supervisor |
| Lukasz Bukowiecki | VFX Editor |
| Eric Dvorsky | Aerial Camera Technician |
| Iain McFadyen | Art Direction |
| Graham Martin | VFX Production Coordinator |
| Jerry Kung | Lead Animator |
| Peter White | Set Costumer |
| Jason B. Stamey | Casting Associate |
| Christopher Flick | Foley |
| Nashia Wachsman | Music Editor |
| Martin Allan Kloner | Visual Effects Editor |
| Michael Rintoul | Thanks |
| Ashley Marie Parker | Set Costumer |
| Sara Cobbeldick | Set Costumer |
| Jerry Bingham | Thanks |
| Nik Korda | Executive Producer |
| Michael Crow | Assistant Costume Designer |
| Simone Kraus Townsend | Animation Supervisor |
| Simon Morgan | First Assistant Editor |
| Javier Arrieta | Key Costumer |
| Adrian Corsei | VFX Supervisor |
| Daniel Frank | Assistant Art Director |
| Lluis Casals Marsol | Animation Director |
| Lidia Martinez Prado | Animation Director |
| Kevin Houlihan | Assistant Art Director |
| Adam Kimmerlin | First Assistant Editor |
| Jim Starlin | Characters |
| Simon Hatt | Associate Producer |
| Adam Heinis | Special Effects Coordinator |
| Darryl Humber | Dolly Grip |
| C. Alan Rawlins | Key Grip |
| Ian Bender | Boom Operator |
| Maxime Cazaly | Creature Technical Director |
| Francis Leong | Creature Technical Director |
| Andy Park | Visual Development |
| Jack Taggart | Ager/Dyer |
| Austin Harris | Aerial Camera |
| Steven Blizzard | Drone Operator |
| Bill Mantlo | Characters |
| Steven Sandles | Creature Technical Director |
| Roger Stern | Thanks |
| Haisu Wang | Assistant Art Director |
| Hannah Greene | Costume Coordinator |
| Sanford Slepak | Key Costumer |
| Casey Crespo | Seamstress |
| Ron Newburn | Gaffer |
| John Slade | Techno Crane Operator |
| Paul Hymns | Key Grip |
| Tina Fabulic | Key Hair Stylist |
| Kate Katz | Prosthetic Makeup Artist |
| Babak Bina | 3D Generalist |
| Daniel Perez | 3D Generalist |
| David O'Donnell | 3D Generalist |
| Sebastian Schmall | 3D Generalist |
| Arslan Elver | Animation Supervisor |
| Alvise Avati | Lead Animator |
| Patrick Smith | Pre-Visualization Supervisor |
| Dominic Mayer | VFX Editor |
| Jan Reichmann | VFX Editor |
| Duncan Williams | Visual Effects Editor |
| Jason C. Lewis | Boom Operator |
| Jacob Riehle | First Assistant Sound Editor |
| Mikey Black | Grip |
| Daniel McGraw | Makeup Artist |
| Carolina Jiménez | Layout |
| Jeff Redmond | Thanks |
| Mark Gruenwald | Thanks |
| Steve Gan | Characters |
| John David Duncan | Art Department Assistant |
| Mike Friedrich | Thanks |
| Alexander T.H. Browne | VFX Artist |
| Timothy Green II | Thanks |
| Salvador Larroca | Thanks |
| Aaron Valentino | Thanks |
| Paul Pelletier | Thanks |
