 | Chris Pratt als Peter Quill / Star-Lord |
 | Zoe Saldaña als Gamora |
 | Dave Bautista als Drax the Destroyer |
 | Karen Gillan als Nebula |
 | Pom Klementieff als Mantis |
 | Vin Diesel als Groot (voice) |
 | Bradley Cooper als Rocket (voice) |
 | Sean Gunn als Kraglin / Young Rocket |
 | Chukwudi Iwuji als The High Evolutionary |
 | Will Poulter als Adam Warlock |
 | Maria Bakalova als Cosmo (voice) |
 | Elizabeth Debicki als Ayesha |
 | Sylvester Stallone als Stakar Ogord |
 | Austin Freeman als On-Set Groot / Phlektik Guard |
 | Stephen Blackehart als Steemie Blueliver |
 | Terence Rosemore als Xlomo Smeth |
 | Sarah Alami als Ssssaralami |
 | Jasmine Sunshine Munoz als Hoobtoe |
| Giovannie Cruz als Orloni Peddler |
 | Nico Santos als Recorder Theel |
 | Miriam Shor als Recorder Vim |
| Noa Raskin als Baby Rocket (voice) |
 | Linda Cardellini als Lylla |
 | Asim Chaudhry als Teefs |
 | Mikaela Hoover als Floor |
 | Judy Greer als War Pig (voice) |
| Reinaldo Faberlle als Behemoth (voice) |
 | Tara Strong als Mainframe (voice) |
| Jared Leland Gore als Krugarr |
 | Michael Rosenbaum als Martinex |
 | Elan Gale als Beardy Ravager |
 | Molly C. Quinn als Molly Ravager |
 | Gerardo Davila als Fitz-Gibbonok |
 | Dee Bradley Baker als Blurp (voice) |
| Hanna Pak als Humanimal Turtle Experiment |
 | Jennifer Holland als Administrator Kwol |
 | Nathan Fillion als Master Karja |
| Kyle Mclean als The Boss's Nephew |
 | Benjamin Byron Davis als Bletelsnort |
 | Tiffany Smith als Orgocorp Host Friniki |
| Joe Daru als Security Assistant |
 | Daniela Melchior als Ura |
 | Jonathan Mercedes als Gamora Shoots This Guy! |
 | Jonathan Fritschi als Carrot Head Guard |
| Diego Ward als Carrot Head's Friend |
 | Max Bickelhaup als Kitty Orgosentry |
 | Brandon Morales als Dancing Guard |
| Renae Moneymaker als Violent Orgosentry |
| Alexis Hadesty als Humanimal Rabbit |
 | Tara Warren als Humanimal Kangaroo |
| Candi VandiZandi als Humanimal Monkey |
| Grecia Balboa als Warthog Mother |
 | Caleb Spillyards als Humanimal Panda Bear |
 | Darla Delgado als Neelie |
| Michelle Civile als Blue Jay Postal Worker |
 | Ken Lyle als Rabbit Businessman |
| Elodie Clarke als Humanimal Bush Baby Toddler |
 | John William Wright als Humanimal Hyena |
| Autumn Griffin als Humanimal Bat Child |
| Skylar Huntley als Humanimal Bat Child |
 | Randy Havens als Till |
 | Dane DiLiegro als Unsavory Octopus |
 | Kai Zen als Phyla |
| Sarah Anne als Latti |
| Yael Ocasio als Star Child |
 | Adelynn Spoon als Star Child |
| Henry Heffernan als Star Child |
| Brooklyn Skye Oliver als Star Child |
 | Scarlett Blum als Star Child |
| Baby Dro als Star Child |
| Emery Grilliot als Star Child |
| Amelia Waters als Star Child |
 | Lloyd Kaufman als Gridlemop (voice) |
 | Christopher Fairbank als Broker |
 | Rhett Miller als Bzermikitokolok |
 | Natalia Safran als Controller |
| Murphy Weed als Murf |
 | Michael Rooker als Yondu Udonta |
 | James Gunn als Lambshank (voice) |
| Jessica Fontaine als Phlektik Guard |
 | Karen Abercrombie als Grandma Quill |
 | Gregg Henry als Grandpa Quill |
 | Adriana Leonard als Crying Krylorian Citizen |
| Bonnie Discepolo als Crying Krylorian Citizen |
 | Clare Grant als Crying Krylorian Citizen |
| Grace Gunn als Crying Krylorian Citizen |
| Will Gunn als Crying Krylorian Citizen |
 | Seth Green als Howard the Duck (voice) (uncredited) |
 | Pete Davidson als Phlektik (uncredited) |
| John Murphy | Original Music Composer |
| Sarah Halley Finn | Casting |
| Tatiana S. Riegel | Editor |
| Stan Lee | Characters |
| Kevin Feige | Producer |
| Doc Kane | ADR Mixer |
| Judianna Makovsky | Costume Design |
| Rosemary Brandenburg | Set Decoration |
| James Gunn | Director |
| James Gunn | Writer |
| Mike Mignola | Thanks |
| Jack Kirby | Characters |
| Larry Lieber | Characters |
| Don Heck | Characters |
| Henry Braham | Director of Photography |
| Dave Jordan | Music Supervisor |
| Louis D'Esposito | Executive Producer |
| Fred Raskin | Editor |
| Beth Mickle | Production Design |
| Marco Rubeo | Set Designer |
| Alan Hook | Supervising Art Director |
| Victoria Alonso | Executive Producer |
| Bobcat Goldthwait | Thanks |
| Roy Thomas | Thanks |
| Dan Abnett | Thanks |
| Peter David | Thanks |
| Arnold Drake | Thanks |
| Lorin Flemming | Art Direction |
| Chris Claremont | Thanks |
| Thomas Lappin | "C" Camera Operator |
| Gene Colan | Thanks |
| John Buscema | Characters |
| Alicia Vela-Bailey | Stunt Double |
| David E. Scott | Supervising Art Director |
| Greg D'Auria | Editor |
| Keith Giffen | Characters |
| Wayne Dalglish | Stunt Coordinator |
| David Acord | Sound Designer |
| David Acord | Supervising Sound Editor |
| Sal Buscema | Characters |
| Jane Galli | Makeup Artist |
| Stephane Ceretti | Visual Effects Supervisor |
| Anne Porter | Set Designer |
| Melanie Mascioli | Set Costumer |
| Lars P. Winther | Co-Producer |
| Lars P. Winther | First Assistant Director |
| Andy Lanning | Thanks |
| Tim Croshaw | Set Designer |
| Steve Englehart | Characters |
| John M. 'Jack' Wright | Costume Supervisor |
| Jeffrey A. Humphreys | Boom Operator |
| Sam Situmorang | Stunt Double |
| Jim Valentino | Thanks |
| Zachary Fannin | Art Direction |
| Susan Pickett | Visual Effects Producer |
| Nick S. Cross | Set Designer |
| Laura Baker | Set Costumer |
| Dan Cornwall | Chief Lighting Technician |
| Shari Ratliff | Set Designer |
| Peter Tothpal | Hairstylist |
| Christopher TJ McGuire | "B" Camera Operator |
| Alexei Dmitriew | Makeup Department Head |
| David Butler | Set Costumer |
| Kate Abraham | Set Costumer |
| Linda Traxler | Key Hair Stylist |
| Samantha Avila | Art Direction |
| Nick London | Makeup Artist |
| Nicolas Bosc | Stunts |
| Nicole Sortillon Amos | Makeup Artist |
| Myke Schwartz | Stunts |
| David J. Grant | Co-Producer |
| Robin Pritchard | Makeup Artist |
| Lee Orloff | Sound Mixer |
| Christopher Flick | Foley Supervisor |
| Andrew Simonin | Hairstylist |
| Ed Symon | Set Designer |
| Monique Hyman | Hairstylist |
| Jerry Bingham | Thanks |
| Nik Korda | Executive Producer |
| Heidi Moneymaker | Stunt Coordinator |
| Ben Aycrigg | Stunts |
| Katie Rowe | Stunt Double |
| Jim Starlin | Characters |
| Brittany Hites | Art Direction |
| Caleb Spillyards | Stunts |
| Simon Hatt | Executive Producer |
| Gil Kane | Thanks |
| Daniela Medeiros | Set Designer |
| Andy Park | Visual Development |
| Renae Moneymaker | Stunts |
| Bill Mantlo | Characters |
| Shaun Farley | Sound Effects Editor |
| Roger Stern | Characters |
| Jim Gunn Sr. | In Memory Of |
| Vincent Bates | Set Designer |
| Danya Bateman | Stunts |
| Rob de Groot | Stunt Double |
| Marie Fink | Stunts |
| Kyle Mclean | Stunt Double |
| Curtis Lyons | Stunts |
| Patrick Dunn-Baker | Set Designer |
| Chris Sanford | Set Designer |
| Kyle S. Plowden | Set Dresser |
| Cassie Russek | Hair Department Head |
| Justin Trudeau | Set Designer |
| Chris Romrell | Stunt Double |
| Rick Remender | Thanks |
| Kristen Jenkins | Set Designer |
| Stan J. White | Set Dresser |
| Valerie Rudolph | Set Costumer |
| Dan Mast | Stunts |
| Heather Galipo | Makeup Artist |
| Zak Howell | Set Dresser |
| Kevin Gentry | Grip |
| Ryan Hartnett | Special Effects Technician |
| Jimmy Kenney | Set Costumer |
| Sabrina Wilson | Makeup Artist |
| Allison Gainza | Special Effects Technician |
| Holly Dowell | Stunts |
| James Edward Tilden | Second Second Assistant Director |
| Gary Peebles | Stunt Double |
| Marshall T. Broyles | Special Effects Technician |
| Bailey Eller | Special Effects Technician |
| Jenny Reyes | Key Costumer |
| Cecilia C. Ice | Stunt Double |
| Kirk A. Jenkins | Stunts |
| Dawn Turner | Hairstylist |
| Brandon M. Shaw | Stunt Double |
| Daniel Norris | Stunts |
| Felix Betancourt | Stunts |
| Ryan J. Pezdirc | Second Second Assistant Director |
| Jana Treadwell | Set Dresser |
| Kevin Vickery | Set Designer |
| Aurélia Agel | Stunt Double |
| Joel Hobbie | Special Effects Technician |
| Kristen B. Adams | Assistant Art Director |
| Matt Sprunger | Makeup Artist |
| Martin J. Gibbons | Special Effects Technician |
| Daniel Acuña | Thanks |
| Mark Gruenwald | Thanks |
| Steve Gan | Characters |
| Joshua Adams | Costumer |
| Silvia Mahapatra | Set Designer |
| Chris McGlamery | Set Dresser |
| Laura C. Cox | Assistant Art Director |
| Wellinton Alves | Thanks |
| Mike Friedrich | Thanks |
| David Iverson | Grip |
| Steve Lightle | Thanks |
| Kade Pittman | Stunts |
| Chris Shaw | In Memory Of |
| Donny Cates | Thanks |
| Amber Shani Hamilton | Hairstylist |
| Timothy Green II | Thanks |
| Marko Djurdjevic | Thanks |
| Salvador Larroca | Thanks |
| Ellette Craddock | Stunt Double |
| David Aragon | Rigging Grip |
| Sara Smith | Executive Producer |
| Paul Pelletier | Thanks |
| JC Lee | Thanks |
| Erika Keck | Stunts |
| Steven Shelby | Stunts |
| Amanda Sprunger | Other |
| Joseph Ramiro | Set Designer |
| Kat Rich | Assistant Art Director |
| Lee Gunn | Thanks |
| Paul Azaceta | Thanks |
| Cory Smith | Thanks |
| Chris Reynolds | Other |
| Chris Reynolds | In Memory Of |
| Annalise Scaffidi | Makeup Artist |
| Gabrielle McMullan | Set Dresser |
| Jacob Stutesman | Special Effects Technician |
| Hayley Stirling | Thanks |
| Dale Dicker | Thanks |
| Ron Dicker | Thanks |
| Robert Earlywine | Thanks |
| John Bent | Thanks |
| Sallie Bent | Thanks |
