 | Dave Chappelle als Thurgood Jenkins / Sir Smoke-a-Lot |
 | Jim Breuer als Brian |
 | Harland Williams als Kenny Davis |
 | Guillermo Díaz als Scarface |
 | Rachel True als Mary Jane Potman |
 | Tommy Chong als Squirrel Master |
 | Clarence Williams III als Samson Simpson |
 | Laura Silverman als Jan |
 | R.D. Reid als Scientist |
 | Gregg Rogell als Pothead |
| Kevin Brennan als Pothead |
| Alice Poon als Supply Clerk |
| Rick Demas als Nasty Nate |
| David Bluestein als Jerry Garcia |
 | Kevin Duhaney als Young Thurgood |
| Matthew Raposo als Young Scarface |
| James Cooper als Young Brian |
| Michael Colton als Young Kenny |
| Paul Brogren als Burger Customer |
 | Neal Brennan als Employee |
| Karen Waddell als Record Store Employee |
| Vincent Marino als Bodega Man |
| Domencio 'Macio' Parrilla als Rasta Man |
| Marcus Burrowes als Rasta Man |
| Mark Henriques als Delivery Guy |
 | Jenni Burke als Overweight Woman |
 | David Mucci als Horse Cop |
| Reg Dreger als Judge |
 | Kevin Rushton als Inmate |
| Paul James Saunders als Doorman |
 | Kyrin Hall als Henchwoman |
 | Joanna Bacalso als Henchwoman |
 | C.J. Lusby als Henchwoman |
 | Angelica Lisk-Hann als Henchwoman |
 | Jacqueline Anderson als Henchwoman Delilah |
| Stephanie Bourgeois als Henchwoman |
 | Ho Chow als Hot Dog Vendor |
| Rummy Bishop als Homeless Guy |
 | Jon Stewart als Enhancement Smoker |
 | Snoop Dogg als Scavenger Smoker |
 | Stephen Baldwin als McGuyver Smoker |
| Marc Cohen als McGuyver Friend |
 | Tracy Morgan als V.J. |
| David Edwards als Addict |
 | Paulino Nunes als SWAT Cop |
 | Jason Blicker als Detective |
 | Dave Nichols als Detective |
 | Sharon Brown als Talking Joint |
| Christopher Mugglebee als Security Guard |
| Raymond Hinton als Security Guard |
 | David Sutcliffe als After School Dad |
 | Daniel DeSanto als After School Son |
| Gladys O'Connor als Grandma Smoker |
 | Willie Nelson als Historian Smoker |
 | Janeane Garofalo als I'm Only Creative When I Smoke Smoker (uncredited) |
 | Bob Saget als Cocaine Addict (uncredited) |
 | Steven Wright als The Guy on the Couch (uncredited) |
| Robert Simonds | Producer |
| Tamra Davis | Director |
| Don Zimmerman | Editor |
| Steven Bernstein | Director of Photography |
| Alf Clausen | Original Music Composer |
| Ira Shuman | Unit Production Manager |
| Christopher Geggie | Property Master |
| Dave Chappelle | Writer |
| Ira Shuman | Co-Producer |
| Neal Brennan | Writer |
| Gary Jones | Music Supervisor |
| Perry Andelin Blake | Production Design |
| Alf Clausen | Conductor |
| Joanna Colbert | Casting |
| Julia Dray | Associate Producer |
| Rita Smith | Associate Producer |
| Brian Campbell | Unit Production Manager |
| Vicki Graef | Costume Design |
| Paul D. Austerberry | Art Direction |
| Mark Lane | Set Decoration |
| Jennifer Deathe | Second Assistant Director |
| Andrew Shea | First Assistant Director |
| Brian Patrick | Set Dresser |
| Brenton Brown | Set Dresser |
| Marlene Rain | Set Decoration Buyer |
| Nigel Churcher | Assistant Art Director |
| Joseph E. Gallagher | Camera Operator |
| Michael J. Latino | First Assistant Camera |
| Mark Nener | Second Assistant Camera |
| Owen Langevin | Sound Mixer |
| Neil Riha | Boom Operator |
| Norman O'Halloran | Gaffer |
| Scott Kincaid | Gaffer |
| Randy Tambling | Key Grip |
| Barry Goodwin | Best Boy Electric |
| Ken Craine | Electrician |
| Paul Soin | Electrician |
| Monty Montgomerie | Grip |
| Michael Rybuck | Grip |
| Ron Renzetti | Grip |
| Steve Klys | Grip |
| John Dolan | Grip |
| Jonathan Nussbaum | Grip |
| John W. Duvall | Grip |
| Martin Malivoire | Special Effects |
| Dean Stewart | Special Effects |
| Bob Hall | Special Effects |
| Kathryn Buck | Script Supervisor |
| Debra Beers | Location Manager |
| Beverley Kolbe | Assistant Location Manager |
| R. Mike King | Assistant Location Manager |
| Jay Du Boisson | Assistant Costume Designer |
| Inge Klaudi | Key Makeup Artist |
| Carol Marinoff | Key Hair Stylist |
| Irene Kent | Makeup Artist |
| Mary A. D'Angelo | Hairstylist |
| Divyo Putney | Hairstylist |
| Jane Conway | Animal Wrangler |
| Rick Parker | Animal Wrangler |
| Dorothy Precious | Production Accountant |
| Beverly Sutton | Production Coordinator |
| Carol Rothel | Assistant Accountant |
| Veronica Miller | Assistant Accountant |
| Kimberley Bradley | Assistant Production Coordinator |
| Tina Gerussi | Local Casting |
| Anne Capizzi | Casting Associate |
| Jane Rogers | Extras Casting |
| Amy Leigh Johnson | Unit Publicist |
| Michael Gibson | Still Photographer |
| Brad Milburn | Production Assistant |
| Michelle Bridgman | Production Assistant |
| Christine Pond | Production Assistant |
| Ross Fraser | Construction Coordinator |
| Neil Montgomerie | Transportation Coordinator |
| Gerry Savoy | Transportation Captain |
| William L. Tataryn | Driver |
| Scott Hill | First Assistant Editor |
| Dean Zimmerman | Assistant Editor |
| Dan Zimmerman | Assistant Editor |
| Lee Michael Searles | Assistant Editor |
| J.J. George | Music Editor |
| Alf Clausen | Orchestrator |
| Dell Hake | Orchestrator |
| Gary S. Gerlich | Supervising Sound Editor |
| Richard LeGrand Jr. | Supervising Sound Editor |
| Elmo Weber | Sound Effects Editor |
| Norval D. Crutcher III | ADR Supervisor |
| Walter Spencer | Dialogue Editor |
| Barbara Harris | ADR Voice Casting |
| William Hooper | Foley Editor |
| David Grimaldi | Foley Editor |
| Armond Ghzanian | Assistant Sound Editor |
| Samuel Webb | Assistant Sound Editor |
| Chris David | Sound Re-Recording Mixer |
| Andy MacDonald | Sound Re-Recording Mixer |
| Linda Lew | Foley Recordist |
| James Ashwill | Foley Mixer |
| Dan O'Connell | Foley Artist |
| John T. Cucci | Foley Artist |
| Richard Malzahn | Visual Effects Supervisor |
