 | Luke Wilson als Henry Poole |
 | George Lopez als Father Salizar |
 | Radha Mitchell als Dawn Stupek |
 | Morgan Lily als Millie Stupek |
 | Adriana Barraza als Esperanza |
 | Cheryl Hines als Meg |
 | Earl Carroll als Mr. Lawrence |
| Noah Dahl als Young Henry Poole |
| Rachel Seiferth als Patience |
| Nick Dash als Security Guard |
 | Andrew Santino als Hospital Orderly |
 | Richard Benjamin als Dr. Fancher |
 | Beth Grant als Josie |
 | Sam Jaeger als Lance |
 | Molly Hagan als Pediatrician |
| Mark Pellington | Director |
| Gary Gilbert | Producer |
| Tom Lassally | Producer |
| Tom Rosenberg | Producer |
| Gary Lucchesi | Producer |
| Richard S. Wright | Producer |
| Albert Torres | Author |
| John Frizzell | Music |
| Eric Schmidt | Director of Photography |
| Lisa Zeno Churgin | Editor |
| Deborah Aquila | Casting |
| Jennifer L. Smith | Casting |
| Tricia Wood | Casting |
| Richard Hoover | Production Design |
| Wendy Chuck | Costume Design |
| Patricia A. Fullerton | Script Supervisor |
| Michael Aguilar | Executive Producer |
| David Kern | Co-Producer |
| Eric Reid | Executive Producer |
| Mark Pellington | Executive Producer |
| Norman Reiss | Executive Producer |
| Deborah Rutherford | Makeup Supervisor |
| Susan Lynch | Set Decoration |
| Colette Slattery | Hairstylist |
| Don Rutherford | Makeup Artist |
| Elizabeth Villamarin | Makeup Artist |
| Solina Tabrizi | Hair Supervisor |
| Suzan Bagdadi | Hairstylist |
| Veronica Lorenz | Makeup Artist |
| Tracey Poirier | Second Assistant Director |
| William Paul Clark | First Assistant Director |
| Michael Babcock | Supervising Sound Editor |
| Robin Lynn Bonaccorsi | Stunt Double |
| Monty L. Simons | Stunt Coordinator |
| Richard Bucher | Stunt Double |
| Kanin Howell | Stunt Double |
