 | Joaquin Phoenix als Theodore Twombly |
 | Scarlett Johansson als Samantha (voice) |
 | Amy Adams als Amy |
 | Rooney Mara als Catherine Klausen |
 | Chris Pratt als Paul |
 | Olivia Wilde als Blind Date |
 | Matt Letscher als Charles |
 | Portia Doubleday als Surrogate Date Isabella |
 | Spike Jonze als Alien Child (voice) |
 | Bill Hader als Chat Room Friend #2 (voice) |
 | Kristen Wiig als SexyKitten (voice) |
 | Artt Butler als Text Voice (voice) |
 | SoKo als Isabella (voice) |
 | Brian Cox als Alan Watts (voice) |
 | Luka Jones als Mark Lewman |
 | Sam Jaeger als Dr. Johnson |
 | Pramod Kumar als Pizza Vendor |
 | Evelyn Edwards als Mother Who Dated Pricks |
 | Lil Buck als Busker / Dancer |
 | Lynn Adrianna als Letter Writer #1 |
 | Lisa Renee Pitts als Letter Writer #2 |
 | Gabe Gomez als Letter Writer #3 |
 | May Lindstrom als Sexy Pregnant TV Star |
 | David Azar als Theodore's Divorce Attorney |
| Guy Lewis als Marriage Counselor |
 | Melanie Seacat als Nice Lady |
 | Steve Zissis als New Sweet Boyfriend of Mother Who Dated Pricks |
 | Dane White als Son |
| Nicole Grother als Daughter |
 | James Ozasky als Catherine's Dad |
 | Samantha Sarakanti als Mother of Newborn |
 | Gracie Prewitt als Jocelyn (Birthday Girl) |
 | Claudia Choi als Uncomfortable Waitress |
 | Laura Kai Chen als Tatiana |
 | Wendy Leon als Grocery Shopper |
 | Alia Janine als Commuter |
 | Brian D. Johnson als OS1 Commercial Lead |
| Robert Benard als Michael Wadsworth (Editor) |
| Lisa Cohen als Michael Wadsworth's Wife |
| Grant Samson als Michael Wadsworth's Associate |
| Spike Jonze | Writer |
| Owen Pallett | Original Music Composer |
| Hoyte van Hoytema | Director of Photography |
| Daniel Lupi | Executive Producer |
| K.K. Barrett | Production Design |
| Spike Jonze | Producer |
| Chelsea Barnard | Executive Producer |
| Megan Ellison | Producer |
| Spike Jonze | Director |
| Natalie Farrey | Executive Producer |
| Jeff Buchanan | Editor |
| Eric Zumbrunnen | Editor |
| Vincent Landay | Producer |
| Scott Rogers | Stunt Coordinator |
| Chris Haarhoff | Steadicam Operator |
| Merrick Morton | Still Photographer |
| Austin Gorg | Art Direction |
| Gene Serdena | Set Decoration |
| Cydney Cornell | Hair Department Head |
| Steve Artmont | Makeup Department Head |
| Casey Storm | Costume Design |
| Tracy Scott | Script Supervisor |
| Drew Kunin | Production Sound Mixer |
| Venessa De Anda | Art Department Coordinator |
| Ren Klyce | Supervising Sound Editor |
| Will Butler | Original Music Composer |
| Lance Acord | Additional Photography |
| Sam Schweikert | Set Production Assistant |
| Mark W. Jones | Driver |
| Charlie Kaufman | Thanks |
| Erik Jessen | First Assistant Editor |
| Gwendolyn Yates Whittle | ADR Editor |
| Coya Elliott | First Assistant Sound Editor |
| Malcolm Fife | Dialogue Editor |
| Steve Slanec | Dialogue Editor |
| David C. Hughes | Sound Effects Editor |
| Jeremy Molod | Assistant Sound Editor |
| Marie Ebbing | Music Editor |
| Thom Brennan | Foley Editor |
| John Roesch | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| Mary Jo Lang | Foley Mixer |
| Chris Navarro | ADR Mixer |
| Bobby Johanson | ADR Mixer |
| Nick Kray | ADR Mixer |
| Thomas J. O'Connell | ADR Mixer |
| David Parker | Sound Re-Recording Mixer |
| Ren Klyce | Sound Re-Recording Mixer |
| Peter Mavromates | Visual Effects Producer |
| Janelle Croshaw Ralla | Visual Effects Supervisor |
| Ben Gibbs | Visual Effects Supervisor |
| Chris Forster | Construction Coordinator |
| Paul E. Stroh | Transportation Coordinator |
| Chris Raines | Transportation Captain |
| Robert T. Chestnut | Transportation Co-Captain |
| Will Weiske | Production Supervisor |
| Daniel Lupi | Unit Production Manager |
| Thomas Patrick Smith | First Assistant Director |
| Robert E. Kay | Second Assistant Director |
| Ellen Lewis | Casting |
| Cassandra Kulukundis | Casting |
| Samantha Morton | Associate Producer |
| Thomas Patrick Smith | Associate Producer |
| Allen Coulter | Set Designer |
| Josh Sheppard | Storyboard Artist |
| Matthew Cavaliero | Property Master |
| Kim Richey | Assistant Property Master |
| Anita Louise Brown | Key Costumer |
| Brian Robinson | Boom Operator |
| Zach Wrobel | Utility Sound |
| Richard Schuler | Location Manager |
| Stephen Mapel | Location Manager |
| Cory Geryak | Chief Lighting Technician |
| Larry Sushinski | Assistant Chief Lighting Technician |
| Kevin Tiesiera | Rigging Gaffer |
| Michael Kenner | Key Grip |
| Demelza Cronin | Production Coordinator |
| Paul Belenardo | Production Accountant |
| John Montgomery | Payroll Accountant |
| Larry Zipf | Sound Recordist |
| Miranda July | Thanks |
| Andrew Garfield | Thanks |
| Sally Potters | Assistant Production Coordinator |
| Scarlett Johansson | Songs |
| Randy James Beckman | Utility Stunts |
| Paul Darnell | Utility Stunts |
| Sam Hargrave | Utility Stunts |
| Jade Quon | Utility Stunts |
| Pete Simpson | Utility Stunts |
| Chad Bowman | Utility Stunts |
| Sean Graham | Utility Stunts |
| Chris O'Hara | Utility Stunts |
| Jason Rodriguez | Utility Stunts |
| Nico Woulard | Utility Stunts |
| Florencia Martin | Set Dressing Buyer |
| Grant Samson | Leadman |
| Jory Alvarado | Set Dresser |
| Michael Garcia | Set Dresser |
| James A. Fleming | Set Dresser |
| Jesse Oliver | Set Dresser |
| Michael Timman | Set Dresser |
| Bobby Pollard | Set Dresser |
| Joshua Towers | Set Dresser |
| Chad R. Davis | On Set Dresser |
| Cindy J. Williams | Assistant Makeup Artist |
| Daniel Curet | Assistant Hairstylist |
| Analucia McGorty | Costumer |
| Amanda Owen | Costumer |
| Amy Parris | Costumer |
| Pedro Chávez | Costumer |
| Hali Gardella | Costume Assistant |
| Wyatt Troll | Second Unit Director of Photography |
| Eduard Grau | Second Unit Director of Photography |
| Ron Goodman | Aerial Director of Photography |
| Zoran Veselic | First Assistant Camera |
| Tommy Klines | First Assistant Camera |
| Keith B. Davis | First Assistant Camera |
| Josh Friz | Second Assistant Camera |
| John Morris | Best Boy Grip |
| Jeff Kunkle | Dolly Grip |
| Amber Maahs | Grip |
| Tom Massimini | Grip |
| Donald S. Hubbell | Grip |
| Rich King | Extras Casting |
| Rob Swanson | Extras Casting |
| Geoffrey Miclat | Casting Associate |
| John Barba | Casting Associate |
| Christopher Doulgeris | VFX Artist |
| Dan Connelly | Visual Effects Producer |
| Chelsea Brewer | Visual Effects Coordinator |
| Kristen Zaik Vazquez | Visual Effects Coordinator |
| Luis Bolivar | VFX Artist |
| Charlie Iturriaga | Visual Effects Supervisor |
| Robin L. D'Arcy | Visual Effects Producer |
| James Pastorius | Visual Effects Supervisor |
| Brice Liesveld | Visual Effects Producer |
| Fredrik Nord | VFX Artist |
| Martin Nilsson | VFX Artist |
| Elia P. Popov | Special Effects Supervisor |
| Roy K. Cancino | Special Effects Technician |
| Sylvia Liu | First Assistant Director |
| Lemon Liu Yi-Man | Second Assistant Director |
| Matt Pang | Second Second Assistant Director |
| Teresa Lee | Third Assistant Director |
| Tian Hang Lu | Art Direction |
| Liang Zhu | First Assistant Camera |
| Fang Nan Lu | Second Assistant Camera |
| Haolong Zhang | Digital Imaging Technician |
| Xun Huang | Sound Mixer |
| Bing Song Li | Boom Operator |
| Song Pu | Boom Operator |
| Wei Jian Sun | Assistant Art Director |
| Ye Li Gu | Costumer |
| Jian Wang | Costumer |
| Zhiyun Su | Casting |
| Miao Liang | Casting Assistant |
| Bo Xian | Key Makeup Artist |
| Shan Shan Wang | Assistant Makeup Artist |
| Shan Shan Wang | Assistant Hairstylist |
| Peng Qiu | Assistant Makeup Artist |
| Peng Qiu | Assistant Hairstylist |
| Feng Hua Mao | Gaffer |
| Darren Bailey | Key Grip |
| Zhong Hao Chen | Property Master |
| Yu Bing Pan | Set Dresser |
