 | Bette Midler als Winifred Sanderson |
 | Sarah Jessica Parker als Sarah Sanderson |
 | Kathy Najimy als Mary Sanderson |
 | Whitney Peak als Becca |
 | Belissa Escobedo als Izzy |
 | Lilia Buckingham als Cassie |
 | Froy Gutierrez als Mike |
 | Sam Richardson als Gilbert |
 | Doug Jones als Billy Butcherson |
 | Tony Hale als Mayor / Reverend Traske |
 | Hannah Waddingham als The Witch Mother |
 | Taylor Henderson als Young Winifred |
 | Nina Kitchen als Young Mary |
 | Juju Journey Brener als Young Sarah |
| Thomas Fitzgerald als John Pritchett |
| Brett Cramp als Mr. Pritchett |
| Kim Niemi als Townsperson |
| Alison Weller als Townsperson |
 | Holly Cinnamon als Townsperson |
| Patrick French als Townsperson |
| Charlotte Peed als Mrs. Smith |
| Ed Peed als Mr. Smith |
 | Austin J. Ryan als Young Billy Butcherson |
 | Michael Tow als Mr. Wilke |
| Brina als School Secretary |
 | Brian Wiles als Rob |
| Owen Earls als Liam |
| Skyla Sousa als Teen Winifred |
| Aiden Torres als Teen Mary |
| Emma Kaufman als Teen Sarah |
| Chhoyang Cheshatsang als Thom |
| Jaylin Pryor als Teen Gilbert |
| Marissa Carpio als Food Stall Woman |
 | Naheem Garcia als Fred |
 | Dan Finnerty als Lucas |
 | Ginger Minj als Drag Queen Winifred |
 | Kornbread Jeté als Drag Queen Mary |
 | Kahmora Hall als Drag Queen Sarah |
| Ryan Rosenthal als Glenn |
 | Juvan Elisma als Alex |
 | Jen D'Angelo als Liam's Mom |
| Mark Fichera als Scary Scarecrow |
| Jordan von Netzer als Roman Soldier |
| Mark Hawker als Puppeteer |
| Shane Dzicek als Puppeteer |
| CJ Walsh als Puppeteer |
 | David Torres Jr. als Teacher (uncredited) |
 | Amanda Shepherd als Emily (archive footage) (uncredited) |
| Amanda Mackey | Casting |
| Ralph Winter | Executive Producer |
| Ralph Winter | Unit Production Manager |
| John Debney | Original Music Composer |
| Cathy Sandrich Gelfond | Casting |
| Steven Haft | Co-Producer |
| Lynn Harris | Producer |
| Elliot Davis | Director of Photography |
| Nelson Coates | Production Design |
| Aldric La'Auli Porter | Co-Producer |
| Aldric La'Auli Porter | First Assistant Director |
| Jeff Carson | Music Editor |
| Anne Fletcher | Director |
| David Kirschner | Executive Producer |
| David Kirschner | Characters |
| David Kirschner | Story |
| Adam Shankman | Executive Producer |
| Tony Gardner | Makeup Effects |
| Buck Damon | Music Supervisor |
| Julia Wong | Editor |
| Mark Vargo | Second Unit Director |
| Mick Garris | Characters |
| Jayson Dumenigo | Stunt Coordinator |
| Salvador Pérez Jr. | Costume Design |
| Matthew C. Jacobs | Supervising Art Director |
| Andrew Baseman | Set Decoration |
| Aaron Vexler | Stunts |
| Kevin Haney | Prosthetics |
| Judson Bell | Special Effects Coordinator |
| Melissa Muik | Supervising Music Editor |
| D. Chris Smith | Sound Designer |
| Allan Magled | Visual Effects Supervisor |
| Karen Baker Landers | Sound Designer |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Staubli | Sound Designer |
| Elaine L. Offers | Makeup Artist |
| Brooke Lyndon-Stanford | VFX Supervisor |
| Jody Fedele | VFX Editor |
| Karyn Huston | Hair Department Head |
| Gala Autumn | Costume Supervisor |
| Philip J. Silvera | Stunt Coordinator |
| Thomas Floutz | Makeup Effects |
| Jen D'Angelo | Writer |
| Fleur Morell | Makeup Department Head |
| Mark Hawker | Special Effects Coordinator |
| Mark Fichera | Stunts |
| Jim Harrison | Music Editor |
| Shane Geraghty | Stunts |
| Shawnna Thibodeau | Stunts |
| Lynzi Grant | Visual Effects Producer |
| Blake Harris | Story |
| Bonnie Hlinomaz | Associate Producer |
| Anthony Hoang | Stunts |
| Joe Fidler | Stunts |
| Heidi Pascoe | Stunt Double |
| David Scharf | Associate Producer |
| Amanda Bianchi | Key Makeup Artist |
| Chrissy Weathersby Ball | Stunt Double |
| Susan McGuire | Unit Production Manager |
| G. Grant Jewett | Stunts |
| Steven Young | Hairstylist |
| Robin Siegel | Makeup Artist |
| Becca GT | Stunt Double |
| Stefan Gesek | Art Direction |
| Alesha Forche | Stunt Double |
| Chelsea Mahr | Stunt Double |
| Blythe Bickham | Key Hair Stylist |
| Elizabeth Newton | Art Direction |
| Amanda MacLeod | Stunt Double |
| Diamond McCall | Hairstylist |
| Lynn Struiksma | Second Assistant Director |
| Tiffany Martinez | Key Hair Stylist |
| Oslyn Holder | Makeup Artist |
| Shane Dzicek | Special Effects |
| Michael A. Romero | Compositing Artist |
| Thurman Martin III | Visual Effects Producer |
