 | Rick Moranis als Wayne Szalinski |
 | Matt Frewer als Big Russ Thompson |
 | Marcia Strassman als Diane Szalinski |
 | Kristine Sutherland als Mae Thompson |
 | Thomas Wilson Brown als Little Russ Thompson |
 | Jared Rushton als Ronald Thompson |
 | Amy O'Neill als Amy Szalinski |
 | Robert Oliveri als Nick Szalinski |
 | Carl Steven als Tommy Pervis |
 | Mark L. Taylor als Don Forrester |
 | Kimmy Robertson als Gloria Forrester |
 | Lou Cutell als Dr. Brainard |
 | Craig Richard Nelson als Professor Frederickson |
| Laura Waterbury als Female Cop |
| Trevor Galtress als Male Cop |
| Martin Aylett als Harold Boorstein |
| Janet Sunderland als Lauren Boorstein |
| Michael A. Stevenson | Editor |
| Hiro Narita | Director of Photography |
| Penney Finkelman Cox | Producer |
| Joe Johnston | Director |
| Ed Naha | Screenplay |
| Tom Schulman | Screenplay |
| Thomas G. Smith | Executive Producer |
| James Horner | Original Music Composer |
| Gregg Fonseca | Production Design |
| Dorree Cooper | Art Direction |
| John Iacovelli | Art Direction |
| Carol Brolaski | Costume Design |
| Del Armstrong | Makeup Artist |
| Rick Moore | Storyboard |
| Michael Cassidy | Stunt Coordinator |
| Stuart Gordon | Story |
| Brian Yuzna | Story |
| Ed Naha | Story |
| Jon Landau | Co-Producer |
| Brian Yuzna | Co-Producer |
| Jeff Pescetto | Songs |
| Mike Fenton | Casting |
| Judy Taylor | Casting |
| Lynda Gordon | Casting |
| Mickey Cassidy | Stunts |
| Anthony G. Schmidt | Stunts |
| Bob Yerkes | Stunts |
| Betsy Magruder | First Assistant Director |
| Michele Panelli-Venetis | Second Assistant Director |
| Wylie Stateman | Sound Designer |
| Garrison M. Singer | Production Accountant |
| Marilyn Bailey | Script Supervisor |
| Steven R. Mathis | Gaffer |
| Denise Pizzini | Set Dresser |
| Brad Einhorn | Property Master |
| Phillip Norwood | Storyboard Artist |
| Charles Collum | Construction Coordinator |
| Scott Martin Gershin | Sound Editor |
| Mark R. La Pointe | Sound Editor |
| Chris Hogan | Sound Editor |
| Lou Kleinman | Dialogue Editor |
| George Fredrick | Dialogue Editor |
| Per Hallberg | Assistant Sound Editor |
| William Dotson | Assistant Sound Editor |
| Victor Grodecki | Foley Editor |
| John Roesch | Foley Artist |
| Ellen Heuer | Foley Artist |
| Greg Orloff | Foley Mixer |
| Carolyn Tapp | Foley Mixer |
| Robert Deschaine | ADR Mixer |
| Jim Henrikson | Music Editor |
| John T. Reitz | Sound Re-Recording Mixer |
| Gregg Rudloff | Sound Re-Recording Mixer |
| David Lowery | Storyboard Artist |
| Cherie Tash | Stunts |
| Bill Kroyer | Opening Title Sequence |
