 | Sid Haig als Captain Spaulding |
 | Bill Moseley als Otis B. Driftwood |
 | Sheri Moon Zombie als Baby Firefly |
 | Karen Black als Mother Firefly |
 | Erin Daniels als Denise Willis |
 | Chris Hardwick als Jerry Goldsmith |
 | Rainn Wilson als Bill Hudley |
 | Jennifer Jostyn als Mary Knowles |
 | Tom Towles als Lieutenant George Wydell |
 | Walton Goggins als Deputy Steve Naish |
 | Matthew McGrory als Tiny Firefly |
 | Robert Allen Mukes als Rufus 'RJ' Firefly Jr. |
 | Dennis Fimple als Grandpa Hugo Firefly |
 | Jake McKinnon als Rufus 'Earl' Firefly Sr. |
 | Harrison Young als Don Willis |
 | Irwin Keyes als Ravelli |
 | Michael J. Pollard als Stucky |
 | Chad Bannon als Killer Karl |
 | William Bassett als Sheriff Frank Huston |
 | David Reynolds als Richard 'Little Dick' Wick |
 | Joe Dobbs III als Gerry Ober |
 | Judith Drake als Skunk Ape Wife |
| Gregg Gibbs als Dr. Wolfenstein |
| Ken Johnson als Skunk Ape Husband |
| Irvin Mosley Jr. als Lewis Dover |
| Tom Towles als George Wydell |
 | Walter Phelan als Dr. Satan |
 | Rob Zombie als Dr. Wolfenstein's assistant (uncredited) |
| Rob Zombie | Original Music Composer |
| Rob Zombie | Director |
| Andy Gould | Producer |
| Tom Richmond | Director of Photography |
| Rob Zombie | Screenplay |
| Alex Poppas | Director of Photography |
| Dean E. Fronk | Casting |
| Donald Paul Pemrick | Casting |
| Amanda Friedland | Costume Design |
| Richard Katzenson | Chef |
| Scott Humphrey | Original Music Composer |
| Sean K. Lambert | Editor |
| Guy Oseary | Executive Producer |
| Andy Given | Executive Producer |
| Danielle Shilling Lovett | Co-Producer |
| Joel Hatch | Associate Producer |
| Kathryn Himoff | Editor |
| Robert K. Lambert | Editor |
| Chris Santini | Construction Coordinator |
| Tony Hill | Set Medic |
| David Blitstein | Special Effects Coordinator |
| Buck Robinson | Sound Mixer |
| Justin Ditter | Wigmaker |
| Allan Yamauchi | Transportation Coordinator |
| Russell J. Smith | Production Illustrator |
| Suzanne Hanover | Still Photographer |
| Joe Clarke | Best Boy Electric |
| Logan Leabo | Gaffer |
| Maria Baker | Set Designer |
| Virginia Landis Albertson | Post Production Supervisor |
| Eric Andresen | Painter |
| Oscar Alvarado | Carpenter |
| Andy Given | Unit Production Manager |
| Michael Krantz | Art Direction |
| Richard C. Miller | First Assistant Camera |
| Christi K. Work | Costume Supervisor |
| Mustaque M. Ashrafi | Makeup Artist |
| Jeff Silberman | Legal Services |
| Dominique Blaskovich | Scenic Artist |
| Kathy Andreasen | Rigging Gaffer |
| Martin Astles | Makeup Effects |
| Bennett Andrews | Greensman |
| Gregg Brazzel | Stunt Coordinator |
| Ron Hardman | Transportation Captain |
| Dominik Feller | Electrician |
| Lisa K. Sessions | Set Decoration |
| William Nuzzo | Craft Service |
| Robert K. Lambert | Associate Producer |
| Erin Smith | Assistant Art Director |
| Gary J. Perticone | Hairstylist |
| Patricia Gundlach | Key Hair Stylist |
| Anthony Aguilar | Propmaker |
| Susan Cahill | Sound Editor |
| Edward Cass | Production Office Coordinator |
| Joe Barnett | Sound Re-Recording Mixer |
| George Koran | Telecine Colorist |
| Toby Forlenza | Script Supervisor |
| Kathryn Loraine Hibbs | Production Accountant |
| Deborah Wuliger | Publicist |
| James P. Lay | Supervising Sound Editor |
| Gregg Gibbs | Production Design |
| Tom Fraser | Camera Operator |
| Richard G. Almo | Driver |
| Laura Lee Connery | Utility Stunts |
| Michael Albala | Lighting Technician |
| Brian Robinson | Boom Operator |
| Benjamin L. Cook | Sound Effects Editor |
| Missy Parker | Art Department Coordinator |
| Eric Klosterman | Location Manager |
| Sean Patrick Crowell | Key Grip |
| Marco Black | First Assistant Director |
| Matthew Kern Atzenhoffer | Set Dresser |
| Bruce Alan Greene | Steadicam Operator |
| Pete Asidilla | Grip |
| Kelly M. Beatty | Key Makeup Artist |
| Ellis J. Barbacoff | Assistant Property Master |
| Christopher Lucchese | Dolly Grip |
| Ty Arnold | Second Assistant Director |
| Eddie Avila | Camera Loader |
| Greg Sacks | Casting Assistant |
| Ben Holiday | Assistant Sound Editor |
| Dennis Fimple | In Memory Of |
| Nancy Reid | Assistant Production Coordinator |
| Tony Bonaventura | Property Master |
| Robert Getty | Dialogue Editor |
| Mary Erstad | Foley Mixer |
| Brian K. Anderson | Swing |
| Jeff Bock | Production Assistant |
| Darrin Denlinger | Storyboard Artist |
| Roy Augenstein | Special Effects Technician |
| Jared Abrams | Second Assistant Camera |
| Mike Anderson | Utility Sound |
| Mark Bourgeois | Assistant Editor |
| Isabel Ferrer | Payroll Accountant |
| Cristina Patterson | Contact Lens Technician |
| Michael Lyle | Foley Artist |
| Cesha Ventre | Costumer |
| Robert Schroer | Second Second Assistant Director |
| David Myers | Additional Second Assistant Camera |
| Adam Tankell | Graphic Designer |
| John Koth | Best Boy Grip |
| Nicole Randall | Stunt Double |
| Chris Bustard | Extras Casting |
| Frederick Howard | Sound Supervisor |
| Jenni Wieland | Assistant Accountant |
| James Flemming | Catering |
| Wayne Toth | Makeup Artist |
| Wayne Toth | Special Effects Makeup Artist |
| Rick Avery | Stunts |
| Derek Marcil | Sound Re-Recording Mixer |
| Alisa Hensley | Stunts |
