 | Pierfrancesco Favino als Tommaso Buscetta |
 | Maria Fernanda Cândido als Maria Cristina de Almeida |
 | Fabrizio Ferracane als Pippo Calò |
 | Fausto Russo Alesi als Giovanni Falcone |
 | Luigi Lo Cascio als Salvatore Contorno |
 | Bruno Cariello als Alfonso Giordano |
 | Giovanni Calcagno als Tano Badalamenti |
 | Rosario Palazzolo als Giovanni De Gennaro |
 | Nicola Calì als Totò Riina |
 | Vincenzo Pirrotta als Luciano Liggio |
 | Pier Giorgio Bellocchio als Cesare |
| Michelangelo Cicirello |
| Gabriele Cicirello als Benedetto Buscetta |
 | Paride Cicirello als Antonio Buscetta |
| Goffredo Maria Bruno als Stefano Bontate |
 | Ludovico Caldarera als Salvatore Cancemi |
 | Alessio Praticò als Scarpuzzedda |
 | Bebo Storti als Franco Coppi |
| Federica Butera als Silvana Buscetta |
| Alberto Gottuso als Giuseppe Inzerillo |
| Pippo Di Marca als Giulio Andreotti |
| Ada Nisticò als Alessandra Buscetta |
| Matteo Contino als Salvatore Inzerillo |
 | Aurora Peres als Bontate's Wife |
 | Simona Distefano |
 | Elia Schilton als TV Journalist |
 | Maria Amato als Melchiorra Buscetta |
| Nunzia Lo Presti als Riina's Wife |
| Edoardo Strano als Father Battesimo |
 | Jonas Bloch |
 | Nicola Siri |
 | Rainer Cadete |
 | Luciano Quirino |
| Edoardo Russo de Ornellas als Tommaso Jr. |
| Francesco Emanuele Chinnici als Giuseppe Floglietta |
 | Antonio Orlando als Michele |
 | Giovanni Crozza Signoris als Tommaso Buscetta (18 Years) |
 | Tatu La Vecchia als Friar Giacinto |
 | Sergio Pierattini als Bunker Rebibbia Court President |
 | Raffaella Lebboroni als Rebibbia Court Attorney |
 | Marco Gambino als Procurator General Pajno |
| Letizia Porcaro als Serafina Buscetta |
 | Vincenzo Ferrera als Attorney Costa |
| Domenico Minà als Attorney Marantonio |
| Domenico Gennaro als Ercolano's Attorney |
 | Carlo Ferreri als Bona's Attorney |
| Paolo La Bruna als Favaro's Attorney |
| Gabriele Arena als Domeniddio's Attorney |
| Antonio Silvia als Liggio's Attorney |
 | Fabrizio Romano als Maxi Trial Attorney #1 |
| Roberto Burgio als Maxi Trial Attorney #2 |
| Matteo Sicuro als Gancemi's Attorney |
 | Claudio Collovà als Gotti's Attorney |
 | Giovanni Vettorazzo als Perugia Court President |
| Michele Celeste als Antonio Rotolo |
| Salvo Scuderi als Tommaso Spadaro |
 | Miriam Previati als Cesare's Wife |
| Turi Di Maria als Vincenzo Buscetta |
| Mario Gioè als Benny Buscetta |
| Vince Cannizzaro als Pietro Buscetta |
| Pietro Pace als Arresting Calò Police Commissioner |
 | Dino Santoro als USA Pizzeria Singer |
| Larry Kapust als USA Client |
| Virgilio Rattoballi als Defendant Burruano |
| Quinzio Quiescenti als Defendant Sinagra |
| Dario Muratore als Defendant Ercolano |
| Raffaella D'Avella als Felicia Baucio |
 | Cinzia Susino als Nightmare Woman |
| Chiaraluce Fiorito als Maxi Trial Standing Woman #1 |
| Viviana Militello als Maxi Trial Standing Woman #2 |
| Marta Limoli als Maxi Trial Standing Woman #3 |
| Annamaria Spina als Maxi Trial Standing Woman #4 |
| Tiziana Cuticchio als Maxi Trial Standing Woman #5 |
 | Leo Wainer als Brazilian Priest |
| Iran Meu Nêgo als Brazilian Bodyguard |
 | André Lamoglia als Felipe |
| Wagner Brant als Brazilian Subsecretary |
| Kenny Alberti als Stefano's Godmother |
| Andé Melo als Brazilian Police Officer #1 |
| Bruno D'Elia als Brazilian Police Officer #2 |
| Douglas Rodrigues als Brazilian Police Officer #3 |
| Joel Tavares als Brazilian Police Officer #4 |
| Vitor Ferrade als Brazilian Police Officer #5 |
| Kael Ferrari als Stefano (2 Years) |
| Oliver Oliveira als Stefano (2 Years) |
| Lorenzo Kauthecher als Stefano (6 Months) |
| Sofia Medeiros als Stefano (6 Months) |
| Rosaria Costa Schifani als Self (archive footage) |
 | Tommaso Buscetta als Self (archive footage) |
| Marco Bellocchio | Screenplay |
| Nicola Piovani | Original Music Composer |
| Marco Bellocchio | Director |
| Vladan Radović | Director of Photography |
| Daria Calvelli | Costume Designer |
| Valia Santella | Screenplay |
| Beppe Caschetto | Producer |
| Francesca Calvelli | Editor |
| Ludovica Rampoldi | Screenplay |
| Maurilio Mangano | Casting |
| Daniela Antonelli Aun | General Manager |
| Emiliano Novelli | Stunt Coordinator |
| Francesco La Licata | Co-Writer |
| Gabriella Marra | Costume Designer |
| Jutta Freyer | Production Design |
| Fabiano Gullane | Co-Producer |
| Arthur Hallereau | Co-Producer |
| Alessandra Tosi | Casting |
| Francesca Borromeo | Casting |
| Rodolfo Migliari | Visual Effects Supervisor |
| André Novis | Associate Producer |
| Caio Gullane | Co-Producer |
| Gregory Gajos | Co-Producer |
| Ana Saito | Co-Executive Producer |
| Marco Bellocchio | Screenstory |
| Francesco Piccolo | Screenplay |
| Patrick de Jongh | Additional Music |
| Simone Gattoni | Executive Producer |
| Francesco Pabilla | Production Coordinator |
| Anna Belluccio | Script Supervisor |
| Anastasia Michelagnoli | Production Designer |
| Pierre-François Piet | Co-Producer |
| Sonia Cilia | Production Director |
| Christian Peritore | Production Director |
| Andrea Castorina | Production Design |
| Francesca Valestro | Production Coordinator |
| Daniela Vilela | Production Design |
| Viola Fügen | Co-Producer |
| Michael Weber | Co-Producer |
| André Ristum | Delegated Producer |
| Paula Cosenza | Co-Executive Producer |
| Domenico Dicillo | Art Direction |
| Michel Merkt | Co-Producer |
| Sergio Basili | Foley Artist |
| Marco Martucci | Set Decoration |
| Livia Del Priore | Set Decoration |
| Valter Casotto | Prosthetic Makeup Artist |
| Federica Castelli | Prosthetic Makeup Artist |
| Laura Inglese | Assistant Production Design |
| Alberto Brunelli | Assistant Set Decoration |
| Bruno De Laurentis | Graphic Designer |
| Giulia Severini | Graphic Designer |
| David Orlandelli | Storyboard Artist |
| Benedetta Cappelloni | Title Designer |
| Sergio Farjalla Jr. | Special Effects Supervisor |
| Lena Di Gennaro | Visual Effects Producer |
| Emiliano Fiore | Camera Operator |
| Leonardo Kurtz | Camera Operator |
| Giuseppe Laruccia | Digital Imaging Technician |
| Dennis Krombach | Gaffer |
| Massimo Dalla Pozza | Grip |
| Danilo De Virgilio | Grip |
| Massimo Virzì | Grip |
| Fabio Fumelli | Key Grip |
| Malte Kneib | Key Grip |
| Wolfgang Ennenbach | Still Photographer |
| Benedetta Benfenanti | Assistant Costume Designer |
| Valeria Maccarone | Assistant Costume Designer |
| Marta Mancuso | Casting Assistant |
| Nike Pirrone | Casting Assistant |
| Pierpaolo Merafino | Boom Operator |
| Gianluca Basili | Sound Effects Editor |
| Antonio Tirinelli | Sound Effects Editor |
| Alexandra Henochsberg | Co-Producer |
| Saverio Lodato | Technical Advisor |
| Gaetano Carito | Sound Recordist |
| Adriano Di Lorenzo | Sound Recordist |
| Lilio Rosato | Sound Editor |
| Francesco Tumminello | Sound Mixer |
| Attilio Moro | General Manager |
| Alberto Mangiante | Assistant Director |
| Giuseppe Pietro Tornatore | Assistant Editor |
| Claudio Misantoni | Assistant Editor |
| Germana Pierucci | Post Production Supervisor |
| Evandro Lima | Sound Recordist |
| Sebastian Fröhlich | General Manager |
| Anna Elisabetta Conti | First Assistant Director |
| Claudio Aloia | Second Assistant Director |
| Massimiliano Sorce | Third Assistant Director |
| Alessio Lazzareschi | Delegated Producer |
| Emiliano Fiore | Steadicam Operator |
| Peter Zuffa | Assistant Camera |
| Tiziano Saraca | Assistant Camera |
| Lisa Bof | Assistant Camera |
| Lia Pasqualino Di Marineo | Still Photographer |
| Toni Giacalone | Camera Operator |
| Giuseppe Trenta | Camera Operator |
| Marta Visconti | Camera Operator |
| Enrico Bellinghieri | Assistant Camera |
| Dario Paolini | Assistant Camera |
| Giovanni Francesco Previtera | Assistant Camera |
| Joy Carnebianca | Assistant Camera |
| Benni Priolisi | Assistant Camera |
| Francesco Sereni | Graphic Designer |
| Shpetim Bylyku | Set Dresser |
| Massimiliano Di Carlo | Assistant Set Dresser |
| Alberta Giuliani | Key Hair Stylist |
| Dalia Colli | Key Makeup Artist |
| Teresa Patella | Makeup Artist |
| Vittoria Pirrone | Makeup Artist |
| Andrea Leanza | Prosthetic Makeup Artist |
| Lorenzo Tamburini | Prosthetic Designer |
| Valeria Maccarone | Wardrobe Supervisor |
| Fabio Scepi | Gaffer |
| Augusto Bettelli | Electrician |
| Vittorio Lucaferri | Electrician |
| Pietro Carelli | Electrician |
| Konstantin Gehring | Grip |
| Wilson Martins | Key Grip |
| Alice Carvalho | Assistant Set Decoration |
| Nicky Sproten | Production Assistant |
| Anand Puthupparambil | Lighting Technician |
| Yann Hinterthan | Lighting Technician |
| Manuel Dietsche | Lighting Technician |
| Paolo Del Brocco | Producer |
