 | Steve Whitmire als Kermit the Frog / Rizzo the Rat / Beaker / Elvises (voice) |
 | Dave Goelz als The Great Gonzo / Dr. Bunsen Honeydew / Waldorf / Zoot (voice) |
 | Bill Barretta als Pepe the King Prawn / Bobo the Bear / Johnny Fiama / Swedish Chef / Lew Zealand / Howard Tubman / Rowlf the Dog / Elvises (voice) |
 | Eric Jacobson als Miss Piggy / Fozzie Bear / Animal / Yoda / Elvises (voice) |
 | David Arquette als Daniel |
 | Joan Cusack als Rachel Bitterman |
 | Matthew Lillard als Luc Fromage |
 | William H. Macy als Glenn |
 | Whoopi Goldberg als Daniel's 'Boss' |
 | Mel Brooks als Joe Snow (voice) |
 | Carson Daly als Self |
 | Molly Shannon als Self |
 | Chantal Strand als Nancy Nut-What |
 | Dave 'Squatch' Ward als Sally Ann Santa Claus |
 | Brian Henson als Scooter / Janice / Sal Minella (voice) |
 | Kevin Clash als Sam Eagle (voice) |
 | John Henson als Sweetums (voice) |
 | Jerry Nelson als Robin the Frog / Statler / Announcer / Pops / Floyd Pepper |
 | Allan Trautman als Eugene the Tuba Player (voice) |
 | Alice Dinnean |
 | Geoff Redknap |
 | Denise Cheshire |
 | Drew Massey als Muppet Performer |
| Adam Behr |
 | Gord Robertson |
 | Zach Braff als Dr. John "J.D." Dorian |
 | Sarah Chalke als Dr. Elliot Reid |
 | John C. McGinley als Dr. Perry Cox |
 | Judy Reyes als Nurse Carla Espinosa |
 | Neil Flynn als Janitor |
 | Snoop Dogg |
 | Bill Lawrence |
 | Kelly Ripa |
 | Joe Rogan |
 | Robert Smigel als Triumph, the Insult Comic Dog (voice) |
 | John E. Kennedy als Dr. Teeth (voice) |
 | Colin Foo als Security Guard |
| Marci Dacus als Fear Factor Contestant (uncredited) |
| Jim Lewis | Writer |
| Tom Martin | Writer |
| Kirk R. Thatcher | Director |
| Warren Carr | Producer |
| Tony Westman | Director of Photography |
| Linda Vipond | Set Decoration |
| Gregg Featherman | Editor |
| Martin G. Baker | Producer |
| Mark Watters | Original Music Composer |
| Michael S. Bolton | Production Design |
| Juliet Blake | Executive Producer |
| Sandra J. Blackie | Costume Design |
| Brian Henson | Executive Producer |
| James Steuart | Art Direction |
| Ruth Caruso | Co-Producer |
| Bill Barretta | Co-Producer |
| Polly Smith | Costume Design |
| Randal Platt | Second Unit Director of Photography |
| Kelly Moon | Script Supervisor |
| Lana Krotenko | Script Supervisor |
| Marny Eng | Stunt Coordinator |
| Allison Cowitt | Casting |
| Mike Fenton | Casting |
| Lynne Carrow | Casting |
| James Hibbard | Choreographer |
| Warren Carr | Production Manager |
| Patrice Leung | First Assistant Director |
| Tracey Poirier | Second Assistant Director |
| Roxanne Methot | Assistant Art Director |
| Armin Matter | Camera Operator |
| Trevor Butt | First Assistant "A" Camera |
| Brian Rose | First Assistant "B" Camera |
| Grant Swain | Property Master |
| Brian Epp | Assistant Property Master |
| Beth Nelson | Assistant Set Decoration |
| Dave Conway | Construction Coordinator |
| Darren Brisker | Sound Recordist |
| Charles O'Shea | Boom Operator |
| Sara Kohlman | Sound Assistant |
| Simon Hunt | Gaffer |
| Niall Fraser | Best Boy Electric |
| Harvey Fedor | Key Grip |
| Charlie Schultz | Best Boy Grip |
| Martin Udo Haas | Dolly Grip |
| Peter Grotek | Dolly Grip |
| Frank Haddad | Greensman |
| Sandy Cooper | Key Makeup Artist |
| Debra Wiebe | Hairstylist |
| Charles Porlier | Special Effects Makeup Artist |
| Robert Murdoch | Location Manager |
| Teresa Gough | Assistant Location Manager |
| Robert Yeager | Special Effects Coordinator |
| Laura Livingstone | Production Coordinator |
| Adrienne Sol | Assistant Production Coordinator |
| Ron James | Transportation Coordinator |
| Sophie Brodovitch | Script Coordinator |
| Lorne Kostyshin | Craft Service |
| Dino A. Moriana | Music Editor |
| Audrey DeRoche | Music Coordinator |
| Ira Hearshen | Orchestrator |
| Andrew Kinney | Orchestrator |
| Chris Klatman | Orchestrator |
| Don Nemitz | Orchestrator |
| Bill Newlin | Orchestrator |
| J. Eric Schmidt | Orchestrator |
| Nan Schwartz | Orchestrator |
| Stephen James Taylor | Orchestrator |
| Richard Taylor | Sound Supervisor |
| Richard C. Franklin | ADR Supervisor |
| Larry Stensvold | Sound Mixer |
| Stephen Fitzmaurice | Sound Mixer |
| Frank Mazzaro | Online Editor |
| Sati Tooray | Colorist |
